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Fig. 9 | Journal of Biomedical Science

Fig. 9

From: DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD

Fig. 9

DYRK1A promotes EMT and metastasis of hepatocellular carcinoma cells by cooperatively activating STAT3 and SMAD. DYRK1A interacted with TSC1 and activated SMAD2/3 and also interacted with and activated STAT3 in HCC cells. Thus, DYRK1A promoted EMT and metastasis of HCC cells by activating STAT3 and SMAD gene transcription program in an independent way

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Journal of Biomedical Science

ISSN: 1423-0127