Fig. 1

Multidimensional sequence of events of the REMFS and biological system interaction. A The Long noncoding RNA Heat Shock RNA1 (HSR1) in a closed conformation. B REMFS exposures affect the interfacial (IF) water of HSR1 to produce proton tunneling. C Protonation of nucleic acids of HSR1 produce an open HSR1 conformation. D Open HSR1 binds to Heat Shock Factor 1 (HSF1), releases HSP90, then HSF1 trimerizes and forms complex with the HSR1 and the elongation factors 1 alpha (eEF1A) after cell injury. E The complex binds to the Heat Shock Elements (HSE). F and G This process initiates Chaperone translation and transcription. H Chaperones induce autophagy and degradation of abnormal proteins. I Clinical outcomes of REMFS exposures