CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation

Table 2 Change of surface markers in COVID19-EVs

Marker	Level in COVID-19 EVs (compared to HC-EVs)	p-value
CD42a	Upregulated	0.0140
CD41b	Upregulated	0.0140
CD29	Upregulated	0.0070
CD40	Upregulated	0.0070
CD31	Upregulated	0.0140
CD45	Upregulated	0.0070
CD69	No significantly different	0.1608
CD62p	Upregulated	0.0140
HLA-ABC	No significantly different	0.1119
CD9	Upregulated	0.0490
CD49e	Upregulated	0.0070
CD63	No significantly different	0.1608
CD81	No significantly different	0.3706
CD3	Upregulated	0.0070
CD14	Upregulated	0.0070
HLA-DRDPDQ	No significantly different	0.4685
CD56	No significantly different	0.1608
CD11c	Upregulated	0.0070
CD4	Upregulated	0.0140
CD1c	No significantly different	0.0769
CD2	Upregulated	0.0490
CD8	Upregulated	0.0490
CD326	No significantly different	0.0769
CD105	No significantly different	0.3706
SSEA-4	No significantly different	0.1608
CD20	Downregulated	0.0280
CD142	Downregulated	0.0140
CD86	No significantly different	0.0769
CD24	No significantly different	0.2168
CD25	Downregulated	0.0070
MCSP	Downregulated	0.0070
CD146	Downregulated	0.0140
CD44	Downregulated	0.0070
CD133/1	Downregulated	0.0140
ROR1	Downregulated	0.0070
CD19	Downregulated	0.0070
CD209	Downregulated	0.0070

The surface markers of EVs from healthy control (HC) and COVID-19 patients were measured using MACSPlex Exosome Kit (Miltenyi Biotec, #130-108-813) by flow cytometry FACverse. The expression level were presented as mean fluorescence intensity (MFI) and the statistical analysis was calculated using GraphPad Prism (version 9.0) software with an unpaired and nonparametric Student’s t-test with Mann–Whitney test

ISSN: 1423-0127