Fig. 4
From: Homozygous mutation of the LRRK2 ROC domain as a novel genetic model of parkinsonism
Comparison of [18F]FDOPA images from four groups of mice, showing significantly decreased uptake of the ligand among Tg mice: A coregistered coronal [18F]FDOPA images of the non-Tg mouse striatum; B coregistered coronal [18F]FDOPA images of the hLRRK2 mouse striatum; C coregistered coronal [18F]FDOPA images of the hLRRK2 R1441G HEM mouse striatum; D coregistered coronal [18F]FDOPA images of the hLRRK2 R1441G HOM mouse striatum; E average [18F]FDOPA uptake in the region of interest (striatum) in various groups. The uptake values are A, B, C, and D for Group 1,2,3, and 4, respectively Data are presented as the mean ± SD (n = 5–6). *Significant effect, p < 0.05; **Significant effect, p < 0.01; ***Significant effect, p < 0.005; ****Significant effect, p < 0.001