Fig. 3

Co-abundance of Prevotella intermedia and Fusobacterium nucleatum increases from polyps to paired carcinoma tissues. The absolute abundance of A Prevotella intermedia and B Fusobacterium nucleatum increases from polyps (TA) to paired carcinomas (TC). The quantification of bacteria is presented as the amount of microbial genomic DNA per ng of genomic DNA isolated from corresponding tissues. TA adenomatous polyp, TC carcinoma tissue. Tissue samples from the same patients with CRC are linked by lines. ***P value < 0.001; ****P value < 0.0001. The numbers of tissues with the presence or absence of Prevotella intermedia (PI) and Fusobacterium nucleatum (FN) in C cancer tissues and D polyp tissues are presented. E The coexistence of Prevotella intermedia (PI) and Fusobacterium nucleatum (FN) is predominant in polyps with adenocarcinoma lesions