Fig. 4

Despite clinical cardiac dysfunction, the histomorphology of cardiac tissue is often relatively unremarkable in patients with severe COVID-19. Sections of the heart from this patient who died of COVID-19 is essentially normal and lacks both inflammation and necrosis (A). Microvascular injury, as evidence by intra-myocardial thrombi, may play a role in cardiac disease. Fibrin thrombi (asterisk) are highlighted by immunohistochemistry for CD61 (B)(A, hematoxylin and eosin)