Fig. 4

Cancer stem-like sphere cells enriched from HCC cell lines exhibit resistance to SOR. A HepG2 cells, B Hep3B cells, and C Huh7 cells were cultured in ultra-low attachment surface dishes for 14 days to form spheres. The spheres were dispersed into single cells to grow and were then treated with SOR. Cell viability was measured by MTT assay. The graphs represent the cytotoxicity profile of SOR at different concentrations as indicated on 48-h incubation