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Fig. 8 | Journal of Biomedical Science

Fig. 8

From: Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS

Fig. 8

Functional analysis shows that SD modulates gene expression in ALS transgenic (G93A) mice and motor neuron cell line (NSC-34). A A scheme illustrating procedure of data analysis. B Venn diagram of the total number of downregulated genes in G93A mice that upregulated in G93A mice treated by spermidine (G93A + SD). C Heatmap analysis shows that SD modulates the expression level of 387 genes in G93A mice. D Venn diagram of 387 recovered genes by SD versus H3K4me2 ChIP target genes. E A scheme illustrating a work flow of cell experiment. F 2810001G20Rik and Rpl26 gene expressions are upregulated by SD in NSC-34/mSOD1cells compared to wildtype control cells. The graph represents mean-SEM of three separate experiments. Significantly different at **p < 0.01

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Journal of Biomedical Science

ISSN: 1423-0127