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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction

Fig. 1

HDAC6 was overexpressed in lung adenocarcinoma. A HDAC6 mRNA levels show a high abundance in lung adenocarcinoma tissues compared to normal lung adjacent tissues based on the TCGA database and B GEO database (GSE27262). C Kaplan–Meier survival analysis according to HDAC6 levels in a lung adenocarcinoma dataset obtained from GEO (GSE50081). D Relative mRNA expression levels of HDAC6 in clinical lung malignant and benign tissues were quantified by qRT–PCR. Data are presented as the mean ± SEM. *p < 0.05; **p < 0.01. E Protein expression levels of HDAC6 in non-small cell lung cancer cells (H460 and A549), patient-derived malignant cancer cells (ELC12, 16, 17, and 20), and normal lung epithelial cells (BEAS-2B) were quantified by Western blot assay. The intensity was normalized to that of GAPDH. Data are presented as the mean ± SEM. *p < 0.05 vs. BEAS-2B cells (n = 3)

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Journal of Biomedical Science

ISSN: 1423-0127