Fig. 2

ETV5 in branching morphogenesis and neural system development. A ETV5 contributes to the formation of the ureteric bud. GDNF and FGF10 signaling activate the ERK/MAPK cascade and positively regulate ETV5 expression in epithelial cells. SPRY1 acts as a negative regulator of receptor tyrosine kinases and reduces the effect of GDNF signaling. ETV5 modulates lung branching bud growth through the regulation of FGF10-SHH signaling and COP1 in alveolar type II cells and adjacent mesenchyme. B In neurons, NGF-TrkA and BDNF-TrkB complexes activate ETV5 in an ERK/MAPK-dependent mechanism. ETV5 promotes the transcription of vesicular glutamate transporter 3 (VGLUT3), MMP3, MMP13, growth-associated protein (GAP-43), medium neurofilament (NF-M) and light neurofilament (NF-L), contributing to synaptic transmission and neuronal growth