Fig. 1
Lytic reactivation of EBV alters m6A Modification of host cell transcripts
(A) Graphical representation of the work-flow. (B) Number of differentially modified peaks in Akata and LCL during latency and lytic reactivation. (C) Distribution of m6A peaks in four topological regions of cellular RNAs during latency and lytic EBV reactivation. UTR, untranslated region. TTS, Translation termination site. (D) Venn diagram comparing the number of methylated human genes before (latent) and after induction for lytic reactivation in LCL and Akata cells. (E) List of genes that were uniquely methylated during latency and during lytic reactivation in Akata and LCL cells and their corresponding cellular functions. (F) Most significant motifs in cellular m6A peaks identified by STREME (Sensitive, Thorough, Rapid, Enriched Motif Elicitation) [35] in latent and reactivated LCL and Akata cells. The top two motifs with the smallest p- values has been listed