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Table 2 Summary of the amino acid alterations in the PmrAB two-component regulatory system in colistin-resistant subpopulations (COL-RP)

From: Multiple heteroresistance to tigecycline and colistin in Acinetobacter baumannii isolates and its implications for combined antibiotic treatment

Isolate number

Colistin MIC (mg/L)

Amino acid alterations

PmrA

PmrB

PmrC

FA56-COL-RP

> 64

–

E301Ka

–

FA83-COL-RP

> 64

–

G260Db

–

FA1318-COL-RP

> 64

D82N

–

–

FA1323-COL-RP

> 64

–

F222Yb

–

F-1757-COL-RP

> 64

–

R263Hb

–

F-2420-COL-RP

> 64

–

G315Ca

–

FA72-COL-RP

> 64

–

L208Fc

–

  1. aAmino acid alternations in nonfunctional domain of PmrB
  2. bAmino acid alterations in histidine kinase A (HisKA) domain of PmrB
  3. cAmino acid alteration in HAMP domain of PmrB
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Journal of Biomedical Science

ISSN: 1423-0127