Skip to main content
Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever

Fig. 4

RNA-seq of PBMCs segregates transcriptional profiles of individuals progressing to DF or DHF. A–D PBMCs collected at first presentation from DENV-positive individuals progressing to DF (n = 5) or DHF (n = 6) were selected for RNA-seq analysis. A Unsupervised multi-dimensional scaling of the top 500 most variably expressed genes across all samples. B Unsupervised hierarchical clustering of the 2411 differentially expressed genes between DF and DHF cases using the complete method and Euclidian measure of distance. C–D tmod gene set enrichment analysis showing significant BTMs differentially enriched for pairwise comparisons (FDR < 5%).

Back to article page

Journal of Biomedical Science

ISSN: 1423-0127