Fig. 7
From: A tumor microenvironment-based prognostic index for osteosarcoma
Immune and stromal cell infiltration characteristics of TMEindex. A Heatmap of the relationship between TMEindex and 28 immune and stromal cells. Age, gender, vital status, OS time, relapse status and RFS time are shown as patient annotations. B Correlations of TMEindex with abundance of 28 immune and stromal cells. Correlation coefficients are calculated by Spearman’s correlation analysis, with red representing negative correlations and blue representing positive correlations. Blank represents a correlation P-value > 0.05. C Differences in 28 immune and stromal cells between TMEindex-high and TMEindex-low groups. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value, and black dots showed outliers. D–F Differences in ImmuneScore (D), StromalScore (E) and ESTIMATEScore (F) between TMEindex-high and TMEindex-low groups. The blue represents the TMEindex-high group and the yellow represents TMEindex-low group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001