Table 5 Traditional knowledge of aconite unpaired in “eighteen antagonisms”
Ingredient | Antagonistic medicaments | Mechanisms | References |
|---|---|---|---|
Aconitum carmichaeli | Trichosanthes kirilowii | Aggravated inflammatory responses in the heart and kidney and promoted myocardial fibrosis by activating β2-AR/PKA signaling in rats with chronic pressure-overload heart failure | [121] |
Improves hemodynamics and exerts myocardial protection in rats with chronic heart failure | [122] | ||
Pinellia ternata | Fuzi and Pinellia combination aggravated doxorubicin-induced cardiomyopathy associated with PKA/β2AR-Gs signaling | [125] | |
The PKA/β2-AR-Gs/Gi signaling pathway is associated with anti-inflammatory and proapoptotic effects of the Fuzi and Pinellia combination in rats with pressure-overload heart failure | |||
Ampelopsis japonica root | Aconitum carmichaeli combined with Ampelopsis japonica has superior therapeutic effects in rheumatoid arthritis compared with either treatment alone | ||
Bletilla striata rhizome | – | – | |
Fritillaria spp. bulb | – | – |