Fig. 6

The in vivo cytokine release syndrome (CRS) evaluation of BsAb-armed T cells. A Schematic of in vivo CRS model of BsAb-armed T cells. The healthy SCID mice that received T cells, BsAb-armed T cells, or OKT3-induced overactivated T cells were measured B the body weight, C rectal temperatures, and D serum cytokine (IL-2, IL6, INF-γ, and TNF-α) levels at consecutive time points. E Serum cytokine (IL-2, IL6, INF-γ, and TNF-α) levels measured in tumor-bearing SCID mice treated with T cells, BsAb-armed T cells, or OKT3-induced overactivated T cells after 24 h. Bar, SD; *p < 0.05; **p < 0.01; ***p < 0.001