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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145

Fig. 7

 A. muciniphila and its membrane protein Amuc_1100 enhances intestinal CREBH expression which in turn ameliorates colonic ER stress and inflammation induced by DSS and promotes intestinal barrier integrity by upregulating expression of protective gut tight junctions (CLDN5 and CLDN8) but inhibiting the leaky gut mediator, CLDN2. CREBH further coupled with microRNA-143/145 to positively regulate the IGF-1 signalling pathway involved in intestinal epithelial regeneration and wound repair. An intact CREBH is essential to mediate the beneficial effect of A. muciniphila and its membrane protein Amuc_1100 in gut health

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Journal of Biomedical Science

ISSN: 1423-0127