Fig. 2

Binding regions of the identified transcription factors in the ACE2 promoter. The numbering of the human and mouse ACE2 promoters are based on Ensembl genome browser (human: ENST00000252519.8; mouse: ENSMUSG00000015405). The numbering for SIRT1 binding sites of the ACE2 promoter are based on UCSC Genome Browser. GATA6: − 351 to − 335, and − 408 to − 403. Ikaros: − 525 to − 519. HNF1α/HNF1β: − 259 to − 242, − 329 to − 312, − 346 to − 330, and − 921 to − 915. STAT3: − 2031 to − 2021. HNF4α: − 5533 to − 5520 and − 7436 to − 7423. SIRT1: − 15,794 to − 15,656, − 15,621 to − 15,521, and − 15,607 to − 15,505. Brg1: − 4089 to − 4001, − 2734 to − 2566, and − 1210 to 1074