Fig. 4
From: ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
A three-dimensional model depicts ACE2 homodimer containing post-translational modification sites. Cα atoms of modified ACE2 residues are marked by spheres. 781YASID784 is the AP2-targeting motif for lysosomal degradation. ACE2 Arg652, Lys657, Lys659 residues, and Ser716 to Ile741 region are the reported ADAM17 cleavage sites. The ACE2 protein structure is obtained from Protein Data Bank (ID: 6M17) and operated by homology modeling using SWISS-MODEL. Dash lines represent undetermined structure of ACE2 protein