Table 3 Downregulation of ACE2 mRNA by miRNA
From: ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
Downregulation of ACE2 mRNA by miRNA | ||
|---|---|---|
Name | Description | Ref. |
miR-125b | miR-125b binds to the 283 to 289 bp (5′-ucaggga-3′) region in ACE2 3′-UTR, leading to reduction of ACE2 mRNA stability under high glucose concentration The miR-125b expression is elevated in the high glucose-exposed cells High-glucose-decreased ACE2 protein levels are recovered by the anti-miR-125b oligonucleotide | [79] |
miR-200c-3p | miR-200c-3p binds to the 165 to 186 bp (5′-auugacauugcuuucaguauuu-3′) region in ACE2 3′-UTR, leading to reduction of ACE2 mRNA stability miR-200c-3p levels are increased in H5N1 influenza virus infected cells H5N1 influenza virus-stimulated miR-200c-3p induction is blocked by NF-κB inhibition H5N1 influenza virus-reduced ACE2 protein levels are increased by the anti-miR-200c-3p oligonucleotides | [82] |
miR-421 | miR-421 binds to the 300 to 314 bp (5′-guaaaugucuguuga-3′) region in ACE2 3′-UTR, leading to reduction of ACE2 mRNA stability | [81] |
miR-483-3p | microRNA library screening shows that miR-483-3p may target and inhibits 3′-UTR of four rennin-angiotensin system (RAS) components, including angiotensinogen, ACE1, ACE2, and the Ang II type 2 receptor | [84] |