Fig. 6

CD73 expression and correlation with EGFR activity, EMT, pEMT, and EGFR-EMT in scRNAseq of HNSCC. A A tSNE plot of the indicated major cell types identified in GSE103322 is depicted with the relative CD73 mRNA expression. B Malignant cells (n = 2716) are shown in a tSNE plot of n = 10 individual patients with highest single cell numbers from GSE103322. Patients´ capture is analogous to the original publication [44]. C CD73 and EGFR mRNA expression are shown from n = 2176 malignant cells of GSE103322 with Spearman correlation r-value and p-value. D Pearson correlation ρ values of CD73 mRNA expression and EGFR pathway activity, EGFR-EMT, hallmark EMT, p-EMT, MAPK and Akt activity GSVA scores across malignant cells (n = 2176) are shown in a correlation heat map for scRNAseq data from n = 10 patients from GSE103322. E CD73 mRNA expression across malignant cells (n = 2,176) is shown in violin plots for n = 10 patients from GSE103322. F EGFR pathway activity, EGFR-EMT, hallmark EMT, p-EMT MAPK and Akt activity GSVA scores across malignant cells (n = 2,176) from CD73^low and CD73^high patients are shown in violin plots for scRNAseq data from GSE103322