Fig. 2

Dietary and genetic factors influencing gastrointestinal homeostasis through the crosstalk between microbiota and NLRP3 inflammasome signaling pathway. Controlled calory intake, ketogenic diet or assumption of omega-3 fatty acids lower NLRP3 inflammasome activation and contribute to the proper homeostasis of the gastrointestinal tract, whereas gain-of-functions, diet rich in cholesterol or saturated fatty acid encourage its activation, recently bridged to inflammation and IBD onset