Fig. 9

Administration of anti-TNF-α monoclonal antibody adalimumab effectively inhibits lung colonization potential of the lung-tropic LC cells. A Strategy of anti-TNF-α therapy in the experimental lung colonization mouse model. Tumor cells-injected mice were treated with weekly injection of adalimumab at a dosage of 10 mg/kg for a total of four injections. B Ex vivo analysis of chemiluminescence signals the mouse lungs using IVIS imaging Lumina LT series III imaging system. C Quantitative results of photon signals of the mouse lungs. *P < 0.05