Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications

Table 1 Non-coding RNAs regulating glucose metabolism in breast cancer

Pathway	Target enzyme	ncRNAs	Function	Refs.
Glucose transport	GLUT	miR-122	Downregulate	[81]
		miR-186-3p	Downregulate	[51]
		LINC00346	Upregulate	[48]
		TSPEAR-AS2	Upregulate	[44]
		circ_0001955	Upregulate	[45]
		circ_0072995	Upregulate	[46]
		circTFF1	Upregulate	[47]
Glycolysis	HK	miR-155	Upregulate	[43]
		circDENND4C	Upregulate	[82]
		circYY1	Upregulate	[83]
		circ_0008039	Upregulate	[84]
		circWHSC1	Upregulate	[85]
		circ_0069094	Upregulate	[86]
		circ_0000442	Downregulate	[87]
		circ_0001982	Upregulate	[88]
		circRNF20	Upregulate	[89]
	PFKFB	circ_0102273	Upregulate	[60]
		tRiMetF31	Downregulate	[61]
		BCAR4	Upregulate	[90]
		circCARM1	Upregulate	[91]
	PFK1	HOXC-AS3	Upregulate	[57]
	PFK1	SNHG5	Upregulate	[55]
	PGK1	miR-16-1-3p	Downregulate	[70]
	PKM2	HIFAL	Upregulate	[69]
		FGD5-AS1	Upregulate	[92]
		circKIF4A	Upregulate	[68]
Lactate or acetyl-CoA	LDHA	DIO3OS	Upregulate	[72]
		miR-34a	Downregulate	[93]
		circPDCD11	Upregulate	[73]
		circKLHL24	Downregulate	[94]
		circCSNK1G1	Upregulate	[74]
		circABCB10	Upregulate	[95]
	PDHX	miR-27b	Downregulate	[76]
Glycogen synthesis and catabolism	PGM5	miR-1224-3p	Downregulate	[79]
Glycogen synthesis and catabolism	G6PC	tRF^{Lys−CTT−010}	Upregulate	[80]

ISSN: 1423-0127