Fig. 4

Small nucleolar host gene 6 (SNHG6) acts as a regulator of hematopoiesis. a High SNHG6 expression is associated with reduced overall survival in acute myeloid leukemia. b SNHG6 knockdown (KD) affects the expression of genes across the genome, implying a trans regulatory function. Blue represents downregulation, red represents upregulation. c SNHG6 KD led to the upregulation of the platelet-associated genes PPBP and PF4, and the erythrocyte-associated genes AHSP and LYAR. d Transcription factors (TFs) strongly associated with the differentially expressed genes (DEGs) upon SNHG6 KD include hematopoiesis-associated TFs such as CEBPZ, GATA1, TAL1, and KLF1. e Gene Ontology (GO) analysis of the DEGs indicates a strong correlation with erythrocyte differentiation. f GO analysis of the TFs known to bind SNHG6 in K562 cells shows a strong association with myeloid differentiation- and hematopoiesis-related pathways