Table 1 Major advantages of synthetic Abs over natural counterparts
Advantages | Description |
|---|---|
Low production costs | Synthetic Abs can be manufactured in large quantities at a relatively low cost, unlike traditional monoclonal Abs, which are derived from animals and can be expensive to produce |
Stability and production | Synthetic Abs can be engineered to exhibit greater stability promoting large-scale production when compared to natural Abs, which may be constrained by factors such as poor stability and host organism production |
Reagent reproducibility | Synthetic Abs are highly reproducible, meaning each batch will have the same properties. This is important for research and diagnostic applications where precise measurements are required |
Increased affinity and specificity | Synthetic Abs can be meticulously engineered to attain superior specificity and affinity for their target when compared to natural Abs. This attribute is crucial for various applications, including diagnostics and medicinal applications |
Customizable antigen recognition site | The antigen recognition site of synthetic Abs can be precisely engineered to target any desired antigen. They can be customized to bind to a diverse array of targets, including those that pose challenges for natural Abs. Accordingly, synthetic Abs are well-suited for targeting specific molecules, including proteins, viruses, or bacteria |
Humanization | Synthetic Abs can be engineered to be fully human, minimizing the risk of immune responses when used in therapeutic applications |