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Table 4 Strategies that produced a significant change in faithful transgene integration in K562 compared to HEK293T cells

From: Improving CRISPR–Cas9 directed faithful transgene integration outcomes by reducing unwanted random DNA integration

Strategy

Cas9 variant

Log2 fold differences

3′ overhang-pair 1

Cas9-Gem

1.496265155

3′ overhang-pair 1

Cas9es

0.901494278

5′ overhang-pair 1

Cas9es

− 1.431344377

Short HA

Cas9es-Gem

− 2.559634321

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Journal of Biomedical Science

ISSN: 1423-0127