Fig. 2

Although TH proteins showed no difference in the early stage of MP mice and the PT320-treated groups, there was a significant difference in cytochrome c release and ROS production at 8 weeks of age, indicating a potential molecular change during the early stage of disease progression. A Cytochrome c protein levels in different age groups of MitoPark and PT320-treated mice. (12kDa, the lower bands) (B) Measurement of ROS production through DCFDA fluorescence. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc test for multiple comparisons. WT vs MP or MP+PT320: *, p < 0.05; **, p < 0.005; ***, p < 0.001; MP vs MP+PT320: #, p < 0.05; ##, p < 0.005. (N = 5)