Fig. 3

Transmission electron microscopy (TEM) was used to examine the number of mitochondria in the striatum. The results indicate that PT320 treatment does not prevent the decline in mitochondrial numbers. Scale bar: 2 µm (A) Representative TEM images are shown for different stages, including wild-type, MitoPark, and PT320-treated MitoPark. B Statistical analysis shows the mitochondrial numbers for these different stages. C The mitochondrial encoding genes ND1, ND2, ND5 expression in early stage. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc test for multiple comparisons. WT vs MP or MP+PT320: *, p < 0.01, **, p < 0.05, ***, p < 0.001. (N = 3)