Dengue virus pathogenesis and host molecular machineries

Sinha, Saumya; Singh, Kinjal; Ravi Kumar, Y. S.; Roy, Riya; Phadnis, Sushant; Meena, Varsha; Bhattacharyya, Sankar; Verma, Bhupendra

doi:10.1186/s12929-024-01030-9

Journal of Biomedical Science

Table 1 Various molecular processes modulated by DENV proteins and host proteins to either enhance or hinder virus replication

From: Dengue virus pathogenesis and host molecular machineries

Molecular Processes	Viral proteins /UTRs	Host proteins /Components	Function	References
Epigenetics		HDAC	Condense chromatin and slow down host transcription	[28]
		CNG7, CCR10, MARF-AS1, CTBP-AS	Localize in cytoplasm to enhance viral replication, proviral effect	[29, 30]
	NS1	DIDO1	NS1 and DIDO1 interaction upregulates viral replication	[35]
	Capsid	H2A, H2B, H3, H4	Capsid colocalize core histones to enhance viral replication	[36]
Transcription	Envelope	TAL-1	Hinder host transcription processes	[37]
		GATA-1, GATA-2, NF-E2	Affects the process of Megakaryopoiesis and decrease platelets production	[38]
		CDK8	Upregulates the glycolysis and metabolic enzyme production. Proviral effect	[39]
	DENV core protein	P-TEFb	Regulates DENV Pathogenesis	[40]
Post-transcriptional	NS5	snRNPs	Alters the process of splicing	[41]
	NS5	RBM10	Generate proviral isoforms via alternative splicing	[42]
	sfRNA	XRN1	Inhibit exonuclease activity and stabilize viral RNA	[43]
	NS3 and NS4A	IRAV and MOV10	Antiviral activity	[44]
Translation		eIF4E	Recognize 5’ Cap of viral RNA	[45]
	sfRNA	G3BP1, G3BP2, Caprin1	Inhibition of interferon stimulated gene (ISG) translation	[46]
	3’ UTR	PABP	Regulates translation of DENV RNA	[47]
Post-translational	NS3	TRIM69	TRIM69 targets NS3 for protesosomal degradation	[48]
	Envelope		Envelope glycosylation helps to attach with host receptors for viral entry, proviral effect	[49,50,51]
	NS1	C1s, C4, MBL	Glycosylated NS1 interacts with C1s, C4, MBL inhibits interferon related response, showing proviral effect	[52]
	NS5	STAT2	Target proteosomal degradation, antiviral effect	[53]
		STAT3	Negatively regulate Type I IFN and Type III interferon responses and enhance viral propagation	[54]
Stress Responses	NS3	TIA1, TIAR	Colocalize to enhance viral propagation	[55]
	3’UTR	G3BP1, G3BP2, DDX6, Caprin1, USP10	Colocalize to enhance viral propagation	[56]
	NS4B	VCP1-NPL4	Proviral effect	[57]
	NS1	ATF3	Contributes to neuroinflammation during dengue infection	[58]

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ISSN: 1423-0127

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