Fig. 2
From: Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
Results of hematoxylin–eosin and immunohistochemical staining performed to measure NLRP3 expression. Representative sections (day 21) of the RVOTs, RVAs, and LVs of the control (healthy rats), experimental (rats with myocarditis), and treatment (MCC950-treated rats with myocarditis) groups after hematoxylin–eosin staining and immunohistochemical staining for CD45 and NLRP3 (magnification, 400 ×). A Average counts of inflammatory cells (lymphocytes and macrophages) in the control (n = 3), experimental (n = 4), and treatment (n = 3) groups. Macrophages (red arrow) and lymphocytes (yellow arrow) were observed in addition to interstitial space edema (blue arrow) and cardiomyocyte necrosis (green arrow). B Relative expression of CD45 in the RVOTs of the control group was compared with that in different heart regions of the experimental and treatment groups. Average CD45 immunostaining results of the control (n = 4), experimental (n = 4), and treatment (n = 4) groups. C Relative expression of NLRP3 in the RVOTs of the control group was compared with that in the experimental and treatment groups. Average NLRP3 immunostaining results of the control (n = 4), experimental (n = 4), and MCC950-treated (n = 4) groups. RVOT, right ventricle outflow tract; RVA, right ventricular apex; LV, left ventricle