Fig. 5
From: Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
ROS, intracellular Ca2+, SR Ca2+, Ca2+ leak, and cytosolic Na+ levels in rat RVOTs. A Tracings and average levels of [Ca2+]i transients and fractional SR Ca2+ release in the RVOT cardiomyocytes of the control (n = 30), experimental (rats with myocarditis; n = 28), and treatment (MCC950-treated rats with myocarditis; n = 30) groups. B Tracings and average SR Ca2+ levels in the RVOT cardiomyocytes of the control (n = 12), experimental (n = 12), and treatment (n = 12) groups. C Tracings and average Ca2+ leak levels in the RVOT cardiomyocytes of the control (n = 19), experimental (n = 14), and treatment (n = 15) groups. D Average levels of cytosolic ROS in the RVOT cardiomyocytes of the control (n = 30), experimental (n = 31), and treatment (n = 25) groups. E Average levels of mitochondrial ROS in the RVOT cardiomyocytes of the control (n = 33), experimental (n = 30), and treatment (n = 33) groups. F Average levels of cytosolic Na+ in the RVOT cardiomyocytes of the control (n = 30), experimental (n = 30), and treatment (n = 29) groups. ROS, reactive oxygen species; SR, sarcoplasmic reticulum; RVOT, right ventricle outflow tract