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  1. Chronic hepatitis B virus (HBV) infection in endemic areas usually starts since infancy and early childhood and persists lifelong. The clinical course varies among different chronic infected subjects. Majority...

    Authors: Jia-Feng Wu and Mei-Hwei Chang
    Citation: Journal of Biomedical Science 2015 22:92
    Content type: Review Published on:

  2. NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8+ T cells. The existence of an atypical cytotoxic CD4+NKG2D+ T cell population has also been found in patients with autoimmune dysfu...

    Authors: Mariel Garcia-Chagollan, Luis Felipe Jave-Suarez, Jesse Haramati, Miriam Ruth Bueno-Topete, Adriana Aguilar-Lemarroy, Ciro Estrada-Chavez, Blanca Estela Bastidas-Ramirez, Ana Laura Pereira-Suarez and Susana del Toro-Arreola
    Citation: Journal of Biomedical Science 2015 22:91
    Content type: Research Published on:

  3. Increasing evidence suggests that transforming growth factor-beta 1 (TGF-β1) triggers epithelial to mesenchymal transition (EMT) and facilitates breast cancer stem cell differentiation. Gelsolin (GSN) is a ubi...

    Authors: Zhi-Yuan Chen, Pei-Wen Wang, Dar-Bin Shieh, Kuan-Ying Chiu and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2015 22:90
    Content type: Research Published on:

  4. Canine parvovirus 2 (CPV-2) remains a significant worldwide canine pathogen and the most common cause of viral enteritis in dogs. The 1 L15 and 7 L15 peptides overlap each other with QPDGGQPAV residues (7-15 o...

    Authors: Serap Derman, Zeynep Akdeste Mustafaeva, Emrah Sefik Abamor, Melahat Bagirova and Adil Allahverdiyev
    Citation: Journal of Biomedical Science 2015 22:89
    Content type: Research Published on:

  5. It is well known that epigenetic modifications play an important role in controlling the regulation of gene expression during the development. Our previous studies have demonstrated that the expression of feta...

    Authors: Yang Xu, Lingjuan Liu, Bo Pan, Jing Zhu, Changlong Nan, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2015 22:88
    Content type: Research Published on:

  7. We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, the in vivo effect of miR-130b on fat de...

    Authors: Shifeng Pan, Xiaojing Yang, Yimin Jia, Yue Li, Rirong Chen, Min Wang, Demin Cai and Ruqian Zhao
    Citation: Journal of Biomedical Science 2015 22:86
    Content type: Research Published on:

  8. Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a wea...

    Authors: Aleksey V. Belikov, Burkhart Schraven and Luca Simeoni
    Citation: Journal of Biomedical Science 2015 22:85
    Content type: Review Published on:

  9. We have previously demonstrated that cigarette smoke is associated with a significant reduction of retinoic acid in rat lungs and the formation of tracheal precancerous lesions. However, the underlying mechani...

    Authors: Yuan Xue, Ethan Harris, Weiqun Wang and Richard C. Baybutt
    Citation: Journal of Biomedical Science 2015 22:84
    Content type: Research Published on:

  10. Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in...

    Authors: Daisy Vanitha John, Yee-Shin Lin and Guey Chuen Perng
    Citation: Journal of Biomedical Science 2015 22:83
    Content type: Review Published on:

  11. Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated re...

    Authors: Mohammad Charkhpour, Hamed Ghavimi, Saeed Ghanbarzadeh, Bahman Yousefi, Arash Khorrami, Mehran Mesgari and Kambiz Hassanzadeh
    Citation: Journal of Biomedical Science 2015 22:82
    Content type: Research Published on:

  12. Neuropathic pain is a very troublesome and difficult pain to treat. Although opioids are the best analgesics for cancer and surgical pain in clinic, only oxycodone among opioids shows better efficacy to allevi...

    Authors: Pao-Pao Yang, Geng-Chang Yeh, Eagle Yi-Kung Huang, Ping-Yee Law, Horace H. Loh and Pao-Luh Tao
    Citation: Journal of Biomedical Science 2015 22:81
    Content type: Research Published on:

  13. Cardiac oxidative stress, bioenergetics and catecholamine play major roles in heart failure progression. However, the relationships between these three dominant heart failure factors are not fully elucidated. ...

    Authors: Shih-Yi Lee, Hui-Chun Ku, Yueh-Hsiung Kuo, Kai-Chien Yang, Ping-Chen Tu, His-Lin Chiu and Ming-Jai Su
    Citation: Journal of Biomedical Science 2015 22:80
    Content type: Research Published on:

  14. The descending noradrenergic (NAergic) system is one of the important endogenous analgesia systems. It has been suggested that noxious stimuli could activate descending NAergic system; nevertheless, the underl...

    Authors: Chia-Yi Liu, Meng-Lam Lee, Chi-Sheng Yang, Chuan-Mu Chen, Ming-Yuan Min and Hsiu-Wen Yang
    Citation: Journal of Biomedical Science 2015 22:79
    Content type: Research Published on:

  15. In 2011, there was an outbreak of Shiga toxin-producing Escherichia coli (STEC) infections in Japan. Approximately 62 % of patients with hemolytic-uremic syndrome also showed symptoms of encephalopathy. To determ...

    Authors: Naotoshi Sugimoto, Hue Leu, Natsumi Inoue, Masaki Shimizu, Tomoko Toma, Mondo Kuroda, Takekatsu Saito, Taizo Wada and Akihiro Yachie
    Citation: Journal of Biomedical Science 2015 22:78
    Content type: Research Published on:

  16. Cisplatin is one of the most commonly used chemotherapy agent for lung cancer. The therapeutic efficacy of cisplatin is limited by the development of resistance.

    Authors: Chun-Hua Dai, Jian Li, Ping Chen, He-Guo Jiang, Ming Wu and Yong-Chang Chen
    Citation: Journal of Biomedical Science 2015 22:77
    Content type: Research Published on:

  17. Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a key regulator of signal cascades of TNF-α receptor and TLR4, and can induce NF-κB activation for preventing cell apoptosis and eliciting infl...

    Authors: Jang-Shiun Wang, Dean Wu, Duen-Yi Huang and Wan-Wan Lin
    Citation: Journal of Biomedical Science 2015 22:76
    Content type: Research Published on:

  18. Studies in recent years have shown that undercarboxylated osteocalcin (uOC) not only maintains bone mineralization, but is also involved in the regulation of atherosclerosis. However, a correlation between uOC...

    Authors: Minfang Zhang, Zhaohui Ni, Wenyan Zhou and Jiaqi Qian
    Citation: Journal of Biomedical Science 2015 22:75
    Content type: Research Published on:

  19. To construct safer recombinant flavivirus vaccine, we exploited Japanese encephalitis virus (JEV) replicon-based platform to generate single-round infectious particles (SRIPs) that expressed heterologous neutr...

    Authors: Yi-Ting Huang, Jia-Teh Liao, Li-Chen Yen, Yung-Kun Chang, Yi-Ling Lin and Ching-Len Liao
    Citation: Journal of Biomedical Science 2015 22:74
    Content type: Research Published on:

  20. Adiponectin levels have been shown to be associated with colorectal cancer (CRC). Furthermore, a newly identified adiponectin receptor, T-cadherin, has been associated with plasma adiponectin levels. Therefore...

    Authors: Jongkeun Park, Injung Kim, Keum Ji Jung, Soriul Kim, Sun Ha Jee and Sungjoo Kim Yoon
    Citation: Journal of Biomedical Science 2015 22:73
    Content type: Research Published on:

  21. Gene mutations that produce misprocessed proteins are linked to many human disorders. Interestingly, some misprocessed proteins retained their biological function when stabilized by low temperature treatment o...

    Authors: Yueqiang Zhang, William G. O’Brien III, Zhaoyang Zhao and Cheng Chi Lee
    Citation: Journal of Biomedical Science 2015 22:72
    Content type: Research Published on:

  22. Many patients with nasopharyngeal carcinoma (NPC) face poor prognosis. Due to its hidden anatomical location, the tumor is usually diagnosed quite late, and despite initially successful treatment with radiatio...

    Authors: Thomas C. Chen, Hee-Yeon Cho, Weijun Wang, Stephanie J. Wetzel, Anupam Singh, Jenny Nguyen, Florence M. Hofman and Axel H. Schönthal
    Citation: Journal of Biomedical Science 2015 22:71
    Content type: Research Published on:

  24. In epilepsy, seizures are generated by abnormal synchronous activity in neurons. In the rat hippocampus (HIP), epileptiform activity has been found to be associated with gap junctions (GJs). GJs are formed by ...

    Authors: Medina-Ceja Laura, Flores-Ponce Xóchitl, Santerre Anne and Morales-Villagrán Alberto
    Citation: Journal of Biomedical Science 2015 22:69
    Content type: Research Published on:

  26. Pulmonary emphysema is characterized histologically by destruction of alveolar walls and enlargement of air spaces due to lung epithelial cell apoptosis. Cell adhesion molecule 1 (CADM1) is an immunoglobulin s...

    Authors: Man Hagiyama, Azusa Yoneshige, Takao Inoue, Yasufumi Sato, Takahiro Mimae, Morihito Okada and Akihiko Ito
    Citation: Journal of Biomedical Science 2015 22:67
    Content type: Research Published on:

  28. Opportunistically nosocomial infections in hospitalized patients are often related to Clostridium difficile infections (CDI) due to disruption of the intestinal micro-flora by antibiotic therapies during hospital...

    Authors: Jui-Hsin Huang, Chia-Wei Wu, Shu-Pei Lien, Chih-Hsiang Leng, Kuang-Nan Hsiao, Shih-Jen Liu, Hsin-Wei Chen, Leung-Kei Siu and Pele Chong
    Citation: Journal of Biomedical Science 2015 22:65
    Content type: Research Published on:

  29. Osteoarthritis (OA) is a common joint disease that causes disabilities in elderly. However, few agents with high efficacy and low side effects have been developed to treat OA. In this study, we evaluated the e...

    Authors: Hsien-Tseng Lu, Ming-Shium Hsieh, Chao-Wen Cheng, Li-Fan Yao, Tsuey-Ying Hsu, Jai Lan, Kwang Yoon Kim, Suk Jung Oh, Yung-Hsiang Chang, Chian-Her Lee, Yung-Feng Lin and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2015 22:64
    Content type: Research Published on:

  31. Reduced cell spreading is a prominent feature of aged dermal fibroblasts in human skin in vivo. Mitochondrial DNA (mtDNA) common deletion has been reported to play a role in the human aging process, however the r...

    Authors: Chunji Quan, Moon Kyun Cho, Daniel Perry and Taihao Quan
    Citation: Journal of Biomedical Science 2015 22:62
    Content type: Research Published on:

  32. Melatonin, the chief secretary product of pineal gland, is a strong free radical scavenger and antioxidant molecule. The radioprotective efficacy and underlying mechanisms refer to its antioxidant role in soma...

    Authors: Shahanshah Khan, Jawahar Singh Adhikari, Moshahid Alam Rizvi and Nabo Kumar Chaudhury
    Citation: Journal of Biomedical Science 2015 22:61
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2022 29:91

  34. The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) influences nigral dopaminergic neurons via autocrine and paracrine mechanisms. The reduction of BDNF expression in Parkinson’s disease substantia nigra...

    Authors: Nancy G. Hernandez-Chan, Michael J. Bannon, Carlos E. Orozco-Barrios, Lourdes Escobedo, Sergio Zamudio, Fidel De la Cruz, Jose L. Gongora-Alfaro, Juan Armendáriz-Borunda, David Reyes-Corona, Armando J. Espadas-Alvarez, Yazmin M. Flores-Martínez, Jose Ayala-Davila, Maria E. Hernandez-Gutierrez, Lenin Pavón, Refugio García-Villegas, Rasajna Nadella…
    Citation: Journal of Biomedical Science 2015 22:59
    Content type: Research Published on:

  36. Although Imatinib mesylate has revolutionized the treatment of chronic myeloid leukemia, some patients develop resistance with progression of leukemia. Alternative or additional targeting of signalling pathway...

    Authors: Samuel Troadec, Mélina Blairvacq, Nassima Oumata, Hervé Galons, Laurent Meijer and Christian Berthou
    Citation: Journal of Biomedical Science 2015 22:57
    Content type: Research Published on:

  37. Recently accumulated evidence suggests that Raf kinase inhibitor protein (RKIP) participates in regulation of many signaling pathways and plays an important role in tumorigenesis and tumor metastasis. However,...

    Authors: Fang Nie, Jianguo Cao, Jinlu Tong, Mingming Zhu, Yuan Gao and Zhihua Ran
    Citation: Journal of Biomedical Science 2015 22:56
    Content type: Research Published on:

  38. Dengue is an important mosquito-borne viral infection that affects millions of persons worldwide. Early diagnosis is necessary to effect appropriate management and decrease mortality. Immunochromatographic tes...

    Authors: Ivan E. Vickers, Kevin M. Harvey, Michelle G. Brown, Kereann Nelson, Marion Bullock DuCasse and John F. Lindo
    Citation: Journal of Biomedical Science 2015 22:55
    Content type: Research Published on:

  40. Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine and elevated in the regions of tissue injury and inflammatory diseases. The deleterious effects of TNF-α on fibroblasts may aggravate heart inflamm...

    Authors: Chih-Chung Lin, Chih-Shuo Pan, Chen-Yu Wang, Shiau-Wen Liu, Li-Der Hsiao and Chuen-Mao Yang
    Citation: Journal of Biomedical Science 2015 22:53
    Content type: Research Published on:

  41. SLC34A2 with highest expressions in lung, small intestine and kidney encoded a type 2b sodium-dependent phosphate transporter (NaPi-IIb). In lung, SLC34A2 only expressed in the apical membran...

    Authors: Yu Wang, Weihan Yang, Qiang Pu, Yan Yang, Sujuan Ye, Qingping Ma, Jiang Ren, Zhixing Cao, Guoxing Zhong, Xuechao Zhang, Lunxu Liu and Wen Zhu
    Citation: Journal of Biomedical Science 2015 22:52
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2019 26:18

  43. Hydrogen sulfide (H2S), a novel gaseous mediator, has been recognized as an important neuromodulator and neuroprotective agent in the nervous system. The present study was undertaken to study the effects of ex...

    Authors: Lei Li, Hong-kun Jiang, Yun-peng Li and Yan-ping Guo
    Citation: Journal of Biomedical Science 2015 22:50
    Content type: Research Published on:

  44. The positive effects of acupuncture at Feng-Chi acupoints on treating epilepsy and insomnia have been well-documented in ancient Chinese literature. However, there is a lack of scientific evidence to elucidate...

    Authors: Pei-Lu Yi, Chin-Yu Lu, Shuo-Bin Jou and Fang-Chia Chang
    Citation: Journal of Biomedical Science 2015 22:49
    Content type: Research Published on:

  45. Breast cancer is classified into three subtypes by the expression of biomarker receptors such as hormone receptors and human epidermal growth factor receptor 2. Triple-negative breast cancer (TNBC) expresses n...

    Authors: Masaaki Kawai, Akio Nakashima, Shinji Kamada and Ushio Kikkawa
    Citation: Journal of Biomedical Science 2015 22:48
    Content type: Research Published on:

  46. Wound healing is an intricate process whereby the skin repairs itself after injury. The epithelial-mesenchymal transition (EMT) is associated with wound healing and tissue regeneration. Naphthochalcone derivat...

    Authors: Ga Young Seo, Manh Tin Ho, Ngoc Thuy Bui, Young Mee Kim, Dongsoo Koh, Youngho Lim, Changlim Hyun and Moonjae Cho
    Citation: Journal of Biomedical Science 2015 22:47
    Content type: Research Published on:

  47. Neuroinflammation with activation of microglia and production of proinflammatory cytokines in the brain plays an active role in epileptic disorders. Brain oxidative stress has also been implicated in the patho...

    Authors: Ying-Hao Ho, Yu-Te Lin, Chih-Wei J. Wu, Yung-Mei Chao, Alice Y. W. Chang and Julie Y. H. Chan
    Citation: Journal of Biomedical Science 2015 22:46
    Content type: Research Published on:

  49. The epidermis forms a critical barrier that is maintained by orchestrated programs of proliferation, differentiation, and cell death. Gene mutations that disturb this turnover process may cause skin diseases. ...

    Authors: Pei-Hsuan Lin, Hsien-Yi Lin, Cheng-Chin Kuo and Liang-Tung Yang
    Citation: Journal of Biomedical Science 2015 22:44
    Content type: Research Published on:

  50. Mutations in heat shock 27 kDa protein 1 (HSP27 or HSPB1) cause distal hereditary motor neuropathy (dHMN) or Charcot-Marie-Tooth disease type 2 F (CMT2F) according to unknown factors. Mutant HSP27 proteins aff...

    Authors: Jinho Lee, Sung-Chul Jung, Jaesoon Joo, Yu-Ri Choi, Hyo Won Moon, Geon Kwak, Ha Kyung Yeo, Ji-Su Lee, Hye-Jee Ahn, Namhee Jung, Sunhee Hwang, Jingeun Rheey, So-Youn Woo, Ji Yon Kim, Young Bin Hong and Byung-Ok Choi
    Citation: Journal of Biomedical Science 2015 22:43
    Content type: Research Published on:
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