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  1. Mitochondria autophagy, termed as mitophagy, is a mechanism of specific autophagic elimination of mitochondria. Mitophagy controls the quality and the number of mitochondria, eliminating dysfunctional or exces...

    Authors: Ruiqiao Guan, Wei Zou, Xiaohong Dai, Xueping Yu, Hao Liu, Qiuxin Chen and Wei Teng
    Citation: Journal of Biomedical Science 2018 25:87
    Content type: Review Published on:

  3. Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli.

    Authors: Jiann-Her Lin, Chih-Hsien Hung, Der-Sheng Han, Shih-Ting Chen, Cheng-Han Lee, Wei-Zen Sun and Chih-Cheng Chen
    Citation: Journal of Biomedical Science 2018 25:85
    Content type: Review Published on:

  6. Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disease with skeletal fragility and variable extra-skeletal manifestations. To date several point mutations in 18 different genes causing...

    Authors: Mehran Kausar, Saima Siddiqi, Muhammad Yaqoob, Sajid Mansoor, Outi Makitie, Asif Mir, Chiea Chuen Khor, Jia Nee Foo and Mariam Anees
    Citation: Journal of Biomedical Science 2018 25:82
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2019 26:31

  7. Metformin is the most commonly used first-line medicine for type II diabetes mellitus. Acting via AMP-activated protein kinase, it has been used for more than 60 years and has an outstanding safety record. Met...

    Authors: Shu-Man Hsieh Li, Shu-Ting Liu, Yung-Lung Chang, Ching-Liang Ho and Shih-Ming Huang
    Citation: Journal of Biomedical Science 2018 25:81
    Content type: Research Published on:

  8. TNS2 is a focal adhesions protein and a binding partner for many proteins, including the receptor tyrosine kinase Axl. Although TNS2 can bind with Axl, the details of their interactions have not been elucidate...

    Authors: Li-Chun Cheng, Yen-Lin Chen, An-Ning Cheng, Alan Yueh-Luen Lee, Chun-Yu Cho, Jhy-Shrian Huang and Shuang-En Chuang
    Citation: Journal of Biomedical Science 2018 25:80
    Content type: Research Published on:

  9. Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors leading to chronic inflammation in the intestin...

    Authors: Linda Chia-Hui Yu
    Citation: Journal of Biomedical Science 2018 25:79
    Content type: Review Published on:

  10. Helicobacter pylori - (H. pylori) play a role in the pathogenesis of gastritis, gastric and duodenal ulcers as well as gastric cancer. A possible involvement of outer membrane vesicles (OMVs) produced by H. pylor...

    Authors: Magdalena Chmiela, Natalia Walczak and Karolina Rudnicka
    Citation: Journal of Biomedical Science 2018 25:78
    Content type: Review Published on:

  11. Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages...

    Authors: Shu-Wen Wan, Betty A. Wu-Hsieh, Yee-Shin Lin, Wen-Yu Chen, Yan Huang and Robert Anderson
    Citation: Journal of Biomedical Science 2018 25:77
    Content type: Review Published on:

  12. The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neur...

    Authors: Yi-Chao Lee, Wan-Chen Huang, Jiann-Her Lin, Tzu-Jen Kao, Hui-Ching Lin, Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang and Chi-Chen Huang
    Citation: Journal of Biomedical Science 2018 25:76
    Content type: Research Published on:

  13. Jaundice is a common symptom of inherited or acquired liver diseases or a manifestation of diseases involving red blood cell metabolism. Recent progress has elucidated the molecular mechanisms of bile metaboli...

    Authors: Huey-Ling Chen, Shang-Hsin Wu, Shu-Hao Hsu, Bang-Yu Liou, Hui-Ling Chen and Mei-Hwei Chang
    Citation: Journal of Biomedical Science 2018 25:75
    Content type: Review Published on:

  14. Alternative polyadenylation (APA) is a widespread phenomenon in the posttranscriptional regulation of gene expression that generates mRNAs with alternative 3′-untranslated regions (3’UTRs). APA contributes to ...

    Authors: Ya-Fei Xu, Ying-Qing Li, Na Liu, Qing-Mei He, Xin-Ran Tang, Xin Wen, Xiao-Jing Yang, Ying Sun, Jun Ma and Ling-Long Tang
    Citation: Journal of Biomedical Science 2018 25:74
    Content type: Research Published on:

  15. Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well...

    Authors: Matteo M Pusceddu and Melanie G Gareau
    Citation: Journal of Biomedical Science 2018 25:73
    Content type: Review Published on:

  16. Neurofibromatosis type 1 (NF1) is a dominantly inherited tumor predisposition syndrome that targets the peripheral nervous system. It is caused by mutations of the NF1 gene which serve as a negative regulator of ...

    Authors: Yah-Huei Wu-Chou, Tzu-Chao Hung, Yin-Ting Lin, Hsing-Wen Cheng, Ju-Li Lin, Chih-Hung Lin, Chung-Chih Yu, Kuo-Ting Chen, Tu-Hsueh Yeh and Yu-Ray Chen
    Citation: Journal of Biomedical Science 2018 25:72
    Content type: Research Published on:

  19. Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelia...

    Authors: Nádia Calvo Martins Okuyama, Fernando Cezar-dos-Santos, Érica Romão Pereira, Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Michelle Mota Sena, Ana Paula Lombardi Pereira, Adriano Martin Felis Aranome, Luis Fernando Lasaro Mangieri, Rodolfo Sanches Ferreira, Maria Angelica Ehara Watanabe and Karen Brajão de Oliveira
    Citation: Journal of Biomedical Science 2018 25:69
    Content type: Research Published on:

  21. Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination requires an E3 ligase, whi...

    Authors: Shih-Han Kao, Han-Tsang Wu and Kou-Juey Wu
    Citation: Journal of Biomedical Science 2018 25:67
    Content type: Review Published on:

  22. Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer worldwide and highly prevalent in less developed regions. Management of ESCC is challenging and involves multimodal tre...

    Authors: Nikki P. Lee, Chung Man Chan, Lai Nar Tung, Hector K. Wang and Simon Law
    Citation: Journal of Biomedical Science 2018 25:66
    Content type: Review Published on:

  23. Helicobacter pylori infection is the principal cause of peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Recent studies have shown that it may interfere with ma...

    Authors: Feng-Woei Tsay and Ping-I Hsu
    Citation: Journal of Biomedical Science 2018 25:65
    Content type: Review Published on:

  24. B cells play an essential role during dengue viral infection. While a major expansion of antibody secreting cells (ASCs) was observed, the importance of these increased frequencies of ASCs remains unclear. The...

    Authors: Kovit Pattanapanyasat, Ladawan Khowawisetsut, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Kanchana Tangnararatchakit, Nopporn Apiwattanakul, Chonnamet Techasaensiri, Premrutai Thitilertdecha, Tipaporn Sae-Ung and Nattawat Onlamoon
    Citation: Journal of Biomedical Science 2018 25:64
    Content type: Research Published on:

  26. Glioblastoma multiforme (GBM) is one of the lethal malignant tumors of the central nervous system. Despite advances made in understanding this complex disease, little has been achieved in improving clinical ef...

    Authors: Ira Sharma, Avninder Singh, Fouzia Siraj and Sunita Saxena
    Citation: Journal of Biomedical Science 2018 25:62
    Content type: Research Published on:

  27. Studies at the molecular level aim to integrate genetic and neurobiological data to provide an increasingly detailed understanding of phenotypes related to the ability in time perception.

    Authors: Victor Marinho, Thomaz Oliveira, Juliete Bandeira, Giovanny R. Pinto, Anderson Gomes, Valéria Lima, Francisco Magalhães, Kaline Rocha, Carla Ayres, Valécia Carvalho, Bruna Velasques, Pedro Ribeiro, Marco Orsini, Victor Hugo Bastos, Daya Gupta and Silmar Teixeira
    Citation: Journal of Biomedical Science 2018 25:61
    Content type: Review Published on:

  28. Cancer stem cells are capable of undergoing cell division after surviving cancer therapies, leading to tumor progression and recurrence. Inhibitory agents against cancer stem cells may be therapeutically used ...

    Authors: Chun-Chia Cheng, Po-Nien Liao, Ai-Sheng Ho, Ken-Hong Lim, Jungshan Chang, Ying-Wen Su, Caleb Gon-Shen Chen, Ya-Wen Chiang, Bi-Ling Yang, Huan-Chau Lin, Yu-Cheng Chang, Chun-Chao Chang and Yi-Fang Chang
    Citation: Journal of Biomedical Science 2018 25:60
    Content type: Research Published on:

  29. Hepatitis B virus (HBV) infection is a common disease worldwide and is known to cause liver disease. C-type lectin 18 (CLEC18) is a novel secretory lectin highly expressed in human hepatocytes. Because the liv...

    Authors: Tsung-Yu Tsai, Cheng-Yuan Peng, Hwai-I Yang, Ya-Lang Huang, Mi-Hua Tao, Shin-Sheng Yuan, Hsueh-Chou Lai and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2018 25:59
    Content type: Research Published on:

  31. Induced pluripotency in cancer cells by ectopic expression of pluripotency-regulating factors may be used for disease modeling of cancers. MicroRNAs (miRNAs) are negative regulators of gene expression that pla...

    Authors: Michele Sook Yuin Hiew, Han Ping Cheng, Chiu-Jung Huang, Kowit Yu Chong, Soon Keng Cheong, Kong Bung Choo and Tunku Kamarul
    Citation: Journal of Biomedical Science 2018 25:57
    Content type: Research Published on:

  32. Sepsis is a life-threatening disease mediated by profound disturbances in systemic inflammatory response to infection. IL-33 is multifunctional regulator of numerous aspects of innate and adaptive immune respo...

    Authors: Zivan M. Babic, Filip Z. Zunic, Jelena M. Pantic, Gordana D. Radosavljevic, Ivan P. Jovanovic, Nebojsa N. Arsenijevic and Miodrag L. Lukic
    Citation: Journal of Biomedical Science 2018 25:56
    Content type: Research Published on:

  35. The nuclear translocation of epidermal growth factor receptor (EGFR) has been considered to play a role in carcinogenesis. However, the relevance of differentially located EGFR proteins in lung cancer remains ...

    Authors: Jinn-Li Wang, Chia-Lang Fang, Yu-Tien Tzeng, Han-Lin Hsu, Sey-En Lin, Ming-Chih Yu, Kuan-Jen Bai, Liang-Shun Wang and Hsingjin Eugene Liu
    Citation: Journal of Biomedical Science 2018 25:53
    Content type: Research Published on:

  36. Parkinson’s disease (PD) is the most common movement disorder and manifests as resting tremor, rigidity, bradykinesia, and postural instability. Pathologically, PD is characterized by selective loss of dopamin...

    Authors: Meng-Ling Chen and Ruey-Meei Wu
    Citation: Journal of Biomedical Science 2018 25:52
    Content type: Review Published on:

  37. Next-generation sequencing (NGS) is a powerful and high-throughput method for the detection of viral mutations. This article provides a brief overview about optimization of NGS analysis for hepatocellular carc...

    Authors: I-Chin Wu, Wen-Chun Liu and Ting-Tsung Chang
    Citation: Journal of Biomedical Science 2018 25:51
    Content type: Review Published on:

  38. Kisspeptin is involved in female reproduction. This study was designed to i- estimate kisspeptin levels in women with polycystic ovary syndrome (PCOS), in comparison with controls, ii- study the correlations b...

    Authors: Fadwa S. Albalawi, Maha H. Daghestani, Mazin H. Daghestani, Abdelmoneim Eldali and Arjumand S. Warsy
    Citation: Journal of Biomedical Science 2018 25:50
    Content type: Research Published on:

  39. Few studies have examined the relationship between the amounts of heavy metal and stroke incidence. The aim of this study was to explore the relationship between levels of heavy metals, including Pb, Hg, As, a...

    Authors: Ching-Huang Lin, Yi-Ting Hsu, Cheng-Chung Yen, Hsin-Hung Chen, Ching-Jiunn Tseng, Yuk-Keung Lo and Julie Y. H. Chan
    Citation: Journal of Biomedical Science 2018 25:49
    Content type: Research Published on:

  40. Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals link...

    Authors: Robert F. Hillary and Una FitzGerald
    Citation: Journal of Biomedical Science 2018 25:48
    Content type: Review Published on:

  41. Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assem...

    Authors: Wei-Chen Hsin, Chan-Hua Chang, Chi-You Chang, Wei-Hao Peng, Chung-Liang Chien, Ming-Fu Chang and Shin C. Chang
    Citation: Journal of Biomedical Science 2018 25:47
    Content type: Research Published on:

  43. Lead (Pb2+) is an environmental neurotoxicant that disrupts neurodevelopment, communication, and organization through competition with Ca2+ signaling. How perinatal Pb2+ exposure affects Ca2+-related gene regulat...

    Authors: Lorenz S. Neuwirth, Greg R. Phillips and Abdeslem El Idrissi
    Citation: Journal of Biomedical Science 2018 25:45
    Content type: Research Published on:

  44. Transmembrane Ca2+ influx is critical for molecular rhythmicity, metabolic activity, and neuropeptide release in the central clock of the suprachiasmatic nucleus (SCN). We previously reported that both the Na+/Ca

    Authors: Pi-Cheng Cheng, Yi-Chi Wang, Ya-Shuan Chen, Ruo-Ciao Cheng, Jyh-Jeen Yang and Rong-Chi Huang
    Citation: Journal of Biomedical Science 2018 25:44
    Content type: Research Published on:

  45. The Myristoylated Alanine-Rich C-kinase Substrate (MARCKS) and MARCKS-like protein 1 (MARCKSL1) have a wide range of functions, ranging from roles in embryonic development to adult brain plasticity and the inf...

    Authors: Mohamed El Amri, Una Fitzgerald and Gerhard Schlosser
    Citation: Journal of Biomedical Science 2018 25:43
    Content type: Review Published on:

  46. Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Mu...

    Authors: Ting-Wei Lee, Ting-I Lee, Yung-Kuo Lin, Yu-Hsun Kao and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2018 25:42
    Content type: Research Published on:

  47. Cholinergic hypothesis of Alzheimer’s disease (AD) is based on the findings that a reduced and/or perturbed cholinergic activity in the central nervous system correlates with cognitive decline in patients with...

    Authors: Alice Hálová, Jana Janoutová, Laura Ewerlingová, Vladimír Janout, Ondřej Bonczek, Tomáš Zeman, Tereza Gerguri, Vladimir J. Balcar and Omar Šerý
    Citation: Journal of Biomedical Science 2018 25:41
    Content type: Research Published on:

  48. Second generation antipsychotics (SGAs) induce glucometabolic side-effects, such as hyperglycemia and insulin resistance, which pose a therapeutic challenge for mental illness. Sphingolipids play a role in gly...

    Authors: Katrina Weston-Green, Ilijana Babic, Michael de Santis, Bo Pan, Magdalene K. Montgomery, Todd Mitchell, Xu-Feng Huang and Jessica Nealon
    Citation: Journal of Biomedical Science 2018 25:40
    Content type: Research Published on:

  49. Whether hepatic progenitor cells (HPCs)/oval cells regenerate liver mass upon chronic liver injury is controversial in mice and has not been conclusively proven in humans and rats. In this study, we examined w...

    Authors: Chin-Sung Chien, Ya-Hui Chen, Hui-Ling Chen, Chiu-Ping Wang, Shang-Hsin Wu, Shu-Li Ho, Wen-Cheng Huang, Chun-Hsien Yu and Mei-Hwei Chang
    Citation: Journal of Biomedical Science 2018 25:39
    Content type: Research Published on:

  50. Millions of people around the world suffer from bone disorders, likes osteoporosis, rheumatoid arthritis (RA), and cancer-induced osteolysis. In general, the bone remodeling balance is determined by osteoclast...

    Authors: Hsiao-Hsuan Wang, Yu-Hsiang Hsu and Ming-Shi Chang
    Citation: Journal of Biomedical Science 2018 25:38
    Content type: Review Published on:
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Journal of Biomedical Science

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