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  1. Acute liver failure (ALF) is a syndrome of severe hepatocyte injury with high rate of mortality. Hepatitis B virus (HBV) infection is the major cause of ALF worldwide, however, the underlying mechanism by whic...

    Authors: Guo-Zhen Liu, Xu-Wen Xu, Shu-Hui Tao, Ming-Jian Gao and Zhou-Hua Hou
    Citation: Journal of Biomedical Science 2021 28:67
    Content type: Research Published on:

  2. Influenza A virus (IAV) evolves strategies to counteract the host antiviral defense for establishing infection. The influenza A virus (IAV) non-structural protein 1 (NS1) is a key viral factor shown to counter...

    Authors: Chun-Yang Lin, Meng-Cen Shih, Hung-Chun Chang, Kuan-Jung Lin, Lin-Fang Chen, Sheng-Wen Huang, Mei-Lin Yang, Sheng-Kai Ma, Ai-Li Shiau, Jen-Ren Wang, Kuan-Ru Chen and Pin Ling
    Citation: Journal of Biomedical Science 2021 28:66
    Content type: Research Published on:

  3. Heterozygous pathogenic variants in STUB1 are implicated in autosomal dominant spinocerebellar ataxia type 48 (SCA48), which is a rare familial ataxia disorder. We investigated the clinical, genetic and functiona...

    Authors: Huan-Yun Chen, Chia-Lang Hsu, Han-Yi Lin, Yung-Feng Lin, Shih-Feng Tsai, Yu-Jung Ho, Ye-Ru Li, Jin-Wu Tsai, Shu-Chun Teng and Chin-Hsien Lin
    Citation: Journal of Biomedical Science 2021 28:65
    Content type: Research Published on:

  4. Mainstay haemophilia treatment, namely intravenous factor replacement, poses several clinical challenges including frequent injections due to the short half-life of recombinant factors, intravenous administrat...

    Authors: Dide Okaygoun, Danielle D. Oliveira, Sooriya Soman and Riccardo Williams
    Citation: Journal of Biomedical Science 2021 28:64
    Content type: Review Published on:

  5. Human Papillomavirus type 16 (HPV16) has been associated with a subset of head and neck cancers. Two HPV encoded oncogenic proteins, E6 and E7, are important for the malignant progression of HPV-associated can...

    Authors: Ssu-Hsueh Tseng, Li Liu, Shiwen Peng, Jinhwi Kim, Louise Ferrall, Chien-Fu Hung and T. -C. Wu
    Citation: Journal of Biomedical Science 2021 28:63
    Content type: Research Published on:

  6. One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropria...

    Authors: Sidnee L. Hedrick, Dan Luo, Sophia Kaska, Kumar Kulldeep Niloy, Karen Jackson, Rupam Sarma, Jamie Horn, Caroline Baynard, Markos Leggas, Eduardo R. Butelman, Mary Jeanne Kreek and Thomas E. Prisinzano
    Citation: Journal of Biomedical Science 2021 28:62
    Content type: Research Published on:

  7. The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating cell–cell adhesion, cell proliferation and cell...

    Authors: Nader Rahimi, Rachel X. Y. Ho, Kevin Brown Chandler, Kyle Oliver Corcino De La Cena, Razie Amraei, Ashley J. Mitchel, Nels Engblom and Catherine E. Costello
    Citation: Journal of Biomedical Science 2021 28:61
    Content type: Research Published on:

  8. Streptococcus pneumoniae is a common cause of post-influenza secondary bacterial infection, which results in excessive morbidity and mortality. Although 13-valent pneumococcal conjugate vaccine (PCV13) vaccinatio...

    Authors: Yi-Yin Chen, Ching-Tai Huang, Shiao-Wen Li, Yi-Jiun Pan, Tzu-Lung Lin, Ya-Yu Huang, Ting-Hsuan Li, Yu-Ching Yang, Yu-Nong Gong and Yu-Chia Hsieh
    Citation: Journal of Biomedical Science 2021 28:60
    Content type: Research Published on:

  9. Huntington’s disease (HD) is one of neurodegenerative diseases, and is defined as a monogenetic disease due to the mutation of Huntingtin gene. This disease affects several cellular functions in neurons, and furt...

    Authors: Chih-Wei Tung, Pin-Yu Huang, Siew Chin Chan, Pei-Hsun Cheng and Shang-Hsun Yang
    Citation: Journal of Biomedical Science 2021 28:59
    Content type: Review Published on:

  10. Transposable elements (TEs) initially attracted attention because they comprise a major portion of the genomic sequences in plants and animals. TEs may jump around the genome and disrupt both coding genes as w...

    Authors: Pu-Sheng Hsu, Shu-Han Yu, Yi-Tzang Tsai, Jen-Yun Chang, Li-Kuang Tsai, Chih-Hung Ye, Ning-Yu Song, Lih-Chiao Yau and Shau-Ping Lin
    Citation: Journal of Biomedical Science 2021 28:58
    Content type: Review Published on:

  12. Sorafenib is a kinase inhibitor that is used as a first-line therapy in advanced hepatocellular carcinoma (HCC) patients. However, the existence of sorafenib resistance has limited its therapeutic effect. Thro...

    Authors: Tong-tong Li, Jie Mou, Yao-jie Pan, Fu-chun Huo, Wen-qi Du, Jia Liang, Yang Wang, Lan-sheng Zhang and Dong-sheng Pei
    Citation: Journal of Biomedical Science 2021 28:56
    Content type: Research Published on:

  13. Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal t...

    Authors: Che-Hung Shen, Chi-Che Hsieh, Kuan-Ying Jiang, Chih-Yu Lin, Nai-Jung Chiang, Ting-Wei Li, Chun-Ting Yen, Wan-Ju Chen, Daw-Yang Hwang and Li-Tzong Chen
    Citation: Journal of Biomedical Science 2021 28:55
    Content type: Research Published on:

  14. Current multiparametric MRI (mp-MRI) in routine clinical practice has poor-to-moderate diagnostic performance for transition zone prostate cancer. The aim of this study was to evaluate the potential diagnostic...

    Authors: Neda Gholizadeh, Peter B. Greer, John Simpson, Jonathan Goodwin, Caixia Fu, Peter Lau, Saabir Siddique, Arend Heerschap and Saadallah Ramadan
    Citation: Journal of Biomedical Science 2021 28:54
    Content type: Research Published on:

  15. Researchers have revealed the combined functions of long noncoding RNAs (lncRNAs) and microRNA (miRNAs) in polycystic ovary syndrome (PCOS). This study aimed to understand the role of nuclear-enriched abundant...

    Authors: Jingran Zhen, Jiangli Li, Xia Li, Xue Wang, Yaling Xiao, Zhengyi Sun and Qi Yu
    Citation: Journal of Biomedical Science 2021 28:53
    Content type: Research Published on:

  16. Chandipura virus (CHPV) is a negative single-stranded RNA virus of the Rhabdoviridae family. CHPV infection has been reported in Central and Western India. CHPV causes acute encephalitis with a case fatality rate...

    Authors: Neha Pandey, Meghana Rastogi and Sunit K. Singh
    Citation: Journal of Biomedical Science 2021 28:52
    Content type: Research Published on:

  17. Endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD), and several PD-related genes are responsible for ER dysfunction. Recent studies suggested LRRK2-G2019S, a pathogenic mutation ...

    Authors: Jee Hoon Lee, Ji-hye Han, Eun-hye Joe and Ilo Jou
    Citation: Journal of Biomedical Science 2021 28:51
    Content type: Research Published on:

  18. Cancer immunotherapy has revolutionized treatment and led to an unprecedented wave of immuno-oncology research during the past two decades. In 2018, two pioneer immunotherapy innovators, Tasuku Honjo and James...

    Authors: Austin W. T. Chiang, Hratch M. Baghdassarian, Benjamin P. Kellman, Bokan Bao, James T. Sorrentino, Chenguang Liang, Chih-Chung Kuo, Helen O. Masson and Nathan E. Lewis
    Citation: Journal of Biomedical Science 2021 28:50
    Content type: Review Published on:

  19. Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for medication delivery mechanisms to navigate the body by allowing them to be swallowed more easily. The gas included in the mi...

    Authors: Ali Jangjou, Amir Hossein Meisami, Kazem Jamali, Mohammad Hadi Niakan, Milad Abbasi, Mostafa Shafiee, Majid Salehi, Ahmad Hosseinzadeh, Ali Mohammad Amani and Ahmad Vaez
    Citation: Journal of Biomedical Science 2021 28:49
    Content type: Review Published on:

  20. Accurate and complete replication of the genome is essential not only for genome stability but also for cell viability. However, cells face constant threats to the replication process, such as spontaneous DNA ...

    Authors: Chia-Ling Hsu, Shin Yen Chong, Chia-Yeh Lin and Cheng-Fu Kao
    Citation: Journal of Biomedical Science 2021 28:48
    Content type: Review Published on:

  21. Elevated transforming growth factor (TGF)-β2 in aqueous humor (AH) has been suggested to contribute to trabecular meshwork (TM) fibrosis and intraocular pressure (IOP) regulation in primary open-angle glaucoma...

    Authors: Nozomi Igarashi, Megumi Honjo, Reiko Yamagishi, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Toshikatsu Kaburaki and Makoto Aihara
    Citation: Journal of Biomedical Science 2021 28:47
    Content type: Research Published on:

  23. Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high individual and societal burden. While not all patients display overt markers of elevated inflammation, significant evidence...

    Authors: Gregory H. Jones, Courtney M. Vecera, Omar F. Pinjari and Rodrigo Machado-Vieira
    Citation: Journal of Biomedical Science 2021 28:45
    Content type: Review Published on:

  24. Cholangiocarcinoma represents the second most common primary liver malignancy. The incidence rate has constantly increased over the last decades. Cholangiocarcinoma silent nature limits early diagnosis and pre...

    Authors: Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao and Jiansong Ji
    Citation: Journal of Biomedical Science 2021 28:44
    Content type: Research Published on:

  25. Coronavirus disease 19 (COVID-19) first appeared in the city of Wuhan, in the Hubei province of China. Since its emergence, the COVID-19-causing virus, SARS-CoV-2, has been rapidly transmitted around the globe...

    Authors: Jing-You Guo, I-Ju Liu, Hsiu-Ting Lin, Mei-Jung Wang, Yu-Ling Chang, Shin-Chang Lin, Mei-Ying Liao, Wei-Chia Hsu, Yi-Ling Lin, James C. Liao and Han-Chung Wu
    Citation: Journal of Biomedical Science 2021 28:43
    Content type: Research Published on:

  26. The evolution of cartilage degeneration is still not fully understood, partly due to its thinness, low radio-opacity and therefore lack of adequately resolving imaging techniques. X-ray phase-contrast imaging ...

    Authors: Annie Horng, Johannes Stroebel, Tobias Geith, Stefan Milz, Alexandra Pacureanu, Yang Yang, Peter Cloetens, Goran Lovric, Alberto Mittone, Alberto Bravin and Paola Coan
    Citation: Journal of Biomedical Science 2021 28:42
    Content type: Research Published on:

  29. Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the treatment of several diseases due to their differentiation and immunomodulatory capabilities and their ability to be easily...

    Authors: Jana Janockova, Lucia Slovinska, Denisa Harvanova, Timea Spakova and Jan Rosocha
    Citation: Journal of Biomedical Science 2021 28:39
    Content type: Review Published on:

  30. Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fi...

    Authors: Hung-Sheng Hua, Heng-Ching Wen, Chih-Ming Weng, Hong-Sheng Lee, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2021 28:38
    Content type: Research Published on:

  31. Low cardiorespiratory fitness (V̇O2peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O2peak, there is conside...

    Authors: Camilla J. Williams, Zhixiu Li, Nicholas Harvey, Rodney A. Lea, Brendon J. Gurd, Jacob T. Bonafiglia, Ioannis Papadimitriou, Macsue Jacques, Ilaria Croci, Dorthe Stensvold, Ulrik Wisloff, Jenna L. Taylor, Trishan Gajanand, Emily R. Cox, Joyce S. Ramos, Robert G. Fassett…
    Citation: Journal of Biomedical Science 2021 28:37
    Content type: Research Published on:

  32. Fibrosis can be defined as an excessive and deregulated deposition of extracellular matrix proteins, causing loss of physiological architecture and dysfunction of different tissues and organs. In the skin, fib...

    Authors: Angelo Giuseppe Condorelli, May El Hachem, Giovanna Zambruno, Alexander Nystrom, Eleonora Candi and Daniele Castiglia
    Citation: Journal of Biomedical Science 2021 28:36
    Content type: Review Published on:

  34. The spread of SARS-CoV-2, the virus that causes Coronavirus Disease 2019 (COVID-19), has been characterized as a worldwide pandemic. Currently, there are few preclinical animal models that suitably represent i...

    Authors: Ssu-Hsueh Tseng, Brandon Lam, Yu Jui Kung, John Lin, Li Liu, Ya Chea Tsai, Louise Ferrall, Richard B. S. Roden, T. C. Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2021 28:34
    Content type: Research Published on:

  35. The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase superfamily originally studied in cancer cells where it was found to stimulate cell cycle progression and migration. RhoA acts a...

    Authors: Lucia Sophie Kilian, Jakob Voran, Derk Frank and Ashraf Yusuf Rangrez
    Citation: Journal of Biomedical Science 2021 28:33
    Content type: Review Published on:

  36. Leiomyosarcoma (LMS), the most common soft tissue sarcoma, exhibits heterogeneous and complex genetic karyotypes with severe chromosomal instability and rearrangement and poor prognosis.

    Authors: Po-Hsuan Su, Rui-Lan Huang, Hung-Cheng Lai, Lin-Yu Chen, Yu-Chun Weng, Chih-Chien Wang and Chia-Chun Wu
    Citation: Journal of Biomedical Science 2021 28:32
    Content type: Research Published on:

  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Fang Wang, Xiaochun Wang, Jingruo Li, Pengwei Lv, Mingli Han, Lin Li, Zhuo Chen, Lingling Dong, Nan Wang and Yuanting Gu
    Citation: Journal of Biomedical Science 2021 28:31
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2021 28:4

  38. A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. B...

    Authors: Nan Sun, Xiangqi Meng, Yuxiang Liu, Dan Song, Chuanlu Jiang and Jinquan Cai
    Citation: Journal of Biomedical Science 2021 28:30
    Content type: Review Published on:

  39. Due to the difficulties in early diagnosing and treating hepatocellular carcinoma (HCC), prognoses for patients remained poor in the past decade. In this study, we established a screening model to discover nov...

    Authors: Yi-Chieh Yang, Ming-Hsien Chien, Tsung-Ching Lai, Min-Che Tung, Yi-Hua Jan, Wei-Ming Chang, Shih-Ming Jung, Ming-Huang Chen, Chun-Nan Yeh and Michael Hsiao
    Citation: Journal of Biomedical Science 2021 28:29
    Content type: Research Published on:

  40. Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy because of their high immunomodulation ability, tropism towards inflamed and injured tissues, and their easy access and iso...

    Authors: Wei-Zhan Zhuang, Yi-Heng Lin, Long-Jyun Su, Meng-Shiue Wu, Han-Yin Jeng, Huan-Cheng Chang, Yen-Hua Huang and Thai-Yen Ling
    Citation: Journal of Biomedical Science 2021 28:28
    Content type: Review Published on:

  42. Breast cancer is the most diagnosed malignancy in women. Increasing evidence has highlighted the importance of chronic inflammation at the local and/or systemic level in breast cancer pathobiology, influencing...

    Authors: Sara Socorro Faria, Susan Costantini, Vladmir Cláudio Cordeiro de Lima, Victor Pianna de Andrade, Mickaël Rialland, Rebe Cedric, Alfredo Budillon and Kelly Grace Magalhães
    Citation: Journal of Biomedical Science 2021 28:26
    Content type: Review Published on:

  43. Cardiovascular diseases (CVDs) are considered the predominant cause of morbidity and mortality globally. Of these, myocardial infarction (MI) is the most common cause of CVD mortality. MI is a life-threatening...

    Authors: Chanon Piamsiri, Chayodom Maneechote, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Biomedical Science 2021 28:25
    Content type: Review Published on:

  44. Thyroid hormone analogues—particularly, l-thyroxine (T4) has been shown to be relevant to the functions of a variety of cancers. Integrin αvβ3 is a plasma membrane structural protein linked to signal transduction...

    Authors: Yu-Chen S. H. Yang, Po-Jui Ko, Yi-Shin Pan, Hung-Yun Lin, Jacqueline Whang-Peng, Paul J. Davis and Kuan Wang
    Citation: Journal of Biomedical Science 2021 28:24
    Content type: Review Published on:

  45. To evaluate the impact of hepatitis C virus (HCV) elimination via interferon (IFN)-based therapy on gene expression profiles related to the immune system in HIV/HCV-coinfected patients.

    Authors: Óscar Brochado, Isidoro Martínez, Juan Berenguer, Luz Medrano, Juan González-García, María Ángeles Jiménez-Sousa, Ana Carrero, Víctor Hontañón, Jordi Navarro, Josep M. Guardiola, Amanda Fernández-Rodríguez and Salvador Resino
    Citation: Journal of Biomedical Science 2021 28:23
    Content type: Research Published on:

  46. Obesity-related cardiovascular risk, end points, and mortality are strongly related to arterial stiffening. Current therapeutic approaches for arterial stiffening are not focused on direct targeting within the...

    Authors: Ju-Yi Chen, Yi-Pin Wu, Chih-Yi Li, Huei-Fen Jheng, Ling-Zhen Kao, Ching-Chun Yang, Sy-Ying Leu, I-Chia Lien, Wen-Tsan Weng, Haw-Chih Tai, Yu-Wei Chiou, Ming-Jer Tang, Pei-Jane Tsai and Yau-Sheng Tsai
    Citation: Journal of Biomedical Science 2021 28:22
    Content type: Research Published on:

  47. Breast cancer is the most common solid cancer that affects female population globally. MicroRNAs (miRNAs) are short non-coding RNAs that can regulate post-transcriptional modification of multiple downstream ge...

    Authors: Zhi Xiong Chong, Swee Keong Yeap and Wan Yong Ho
    Citation: Journal of Biomedical Science 2021 28:21
    Content type: Review Published on:

  48. Previous study disclosed Fucosyltransferase 2 (Fut2) gene as a IBD risk locus. This study aimed to explore the mechanism of Fut2 in IBD susceptibility and to propose a new strategy for the treatment of IBD.

    Authors: Xuelian Tang, Weijun Wang, Gaichao Hong, Caihan Duan, Siran Zhu, Yuen Tian, Chaoqun Han, Wei Qian, Rong Lin and Xiaohua Hou
    Citation: Journal of Biomedical Science 2021 28:20
    Content type: Research Published on:

  49. The bile salt export pump (BSEP) is a pivotal apical/canalicular bile salt transporter in hepatocytes that drives the bile flow. Defects in BSEP function and canalicular expression could lead to a spectrum of ...

    Authors: Shang-Hsin Wu, Mei-Hwei Chang, Ya-Hui Chen, Hui-Lin Wu, Huey-Huey Chua, Chin-Sung Chien, Yen-Hsuan Ni, Hui-Ling Chen and Huey-Ling Chen
    Citation: Journal of Biomedical Science 2021 28:19
    Content type: Research Published on:

  50. Glioblastoma is the most common primary malignant brain tumor that is usually considered fatal even with treatment. This is often a result for tumor to develop resistance. Regarding the standard chemotherapy, ...

    Authors: Chia-Hung Chien, Wei-Ting Hsueh, Jian-Ying Chuang and Kwang-Yu Chang
    Citation: Journal of Biomedical Science 2021 28:18
    Content type: Review Published on:
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Journal of Biomedical Science

ISSN: 1423-0127