Skip to main content

Articles

1065 result(s) for 'antibody' within Journal of Biomedical Science

Page 2 of 22

  1. BGC/STC cells (high-expression of STC-1) and BGC/shSTC cells (low- expression of STC-1) were constructed to investigate the effect of STC-1 on the xenograft tumor growth and angiogenesis in vitro and in vivo.... ...

    Authors: Ling-fang He, Ting-ting Wang, Qian-ying Gao, Guang-feng Zhao, Ya-hong Huang, Li-ke Yu and Ya-yi Hou
    Citation: Journal of Biomedical Science 2011 18:39
    Content type: Research Published on:

  2. HEK293 cells were transfected with Cdk5 and its activator p25 as a starting point for an assay to screen for Cdk5 kinase inhibitors. To identify suitable substrates for Cdk5 we utilized an antibody that recognize...

    Authors: Anne Jämsä, Karin Agerman, Ann-Cathrin Radesäter, Jan Ottervald, Jonas Malmström, Gösta Hiller, Gang Liu and Mervi Vasänge
    Citation: Journal of Biomedical Science 2009 16:55
    Content type: Research Published on:

  3. EV-A71 infection transiently increased serum and brain IL-6 protein levels in mice. Most importantly, absence of IL-6 due to gene knockout or depletion of IL-6 using neutralizing monoclonal antibody enhanced the ...

    Authors: Li-Chiu Wang, Hui-Wen Yao, Chuan-Fa Chang, Shainn-Wei Wang, Shih-Min Wang and Shun-Hua Chen
    Citation: Journal of Biomedical Science 2017 24:94
    Content type: Research Published on:

  4. The influenza A virus was isolated for the first time in 1931, and the first attempts to develop a vaccine against the virus began soon afterwards. In addition to causing seasonal epidemics, influenza viruses ...

    Authors: Daria Mezhenskaya, Irina Isakova-Sivak and Larisa Rudenko
    Citation: Journal of Biomedical Science 2019 26:76
    Content type: Review Published on:

  5. Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. hACE2 expression is low in the lungs and is upregulated after SAR...

    Authors: Chao-Fu Yang, Chun-Che Liao, Hung-Wei Hsu, Jian-Jong Liang, Chih-Shin Chang, Hui-Ying Ko, Rue-Hsin Chang, Wei-Chun Tang, Ming-Hao Chang, I-Hsuan Wang and Yi-Ling Lin
    Citation: Journal of Biomedical Science 2023 30:87
    Content type: Research Published on:

  6. Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1 (TIMP1), an inflammatory cytokine, under serum-depleted conditions which leads to suppression of lung cancer cell metastasis has been report...

    Authors: Shan-Ying Wu, Jia-Wen Chen, Hsi-Yu Liu, Yi-Ching Wang, Yeh-Shiu Chu, Chi-Ying Huang, Kai-Ying Lan, Hsiao-Sheng Liu and Sheng-Hui Lan
    Citation: Journal of Biomedical Science 2022 29:103
    Content type: Research Published on:

  7. TLR3 expression in human NB samples was examined by immunohistochemical analysis. Quantitative RT-PCR and western blot was used to determine TLR3 expression in three human NB cell lines. The effect of TLR3 agonis...

    Authors: Jiin-Haur Chuang, Hui-Ching Chuang, Chao-Cheng Huang, Chia-Ling Wu, Yung-Ying Du, Mei-Lang Kung, Chih-Hao Chen, San-Cher Chen and Ming-Hong Tai
    Citation: Journal of Biomedical Science 2011 18:65
    Content type: Research Published on:

  8. Coronavirus-induced disease 19 (COVID-19) infects more than three hundred and sixty million patients worldwide, and people with severe symptoms frequently die of acute respiratory distress syndrome (ARDS). Rec...

    Authors: Pei-Shan Sung, Shao-Ping Yang, Yu-Chun Peng, Cheng-Pu Sun, Mi-Hwa Tao and Shie-Liang Hsieh
    Citation: Journal of Biomedical Science 2022 29:52
    Content type: Research Published on:

  9. We previously reported that Enterovirus 71 (EV71) infection activates autophagy, which promotes viral replication both in vitro and in vivo. In the present study we further investigated whether EV71 infection of ...

    Authors: Ying-Ray Lee, Po-Shun Wang, Jen-Ren Wang and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2014 21:80
    Content type: Research Published on:

  10. The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating cell–cell adhesion, cell proliferation and cell...

    Authors: Nader Rahimi, Rachel X. Y. Ho, Kevin Brown Chandler, Kyle Oliver Corcino De La Cena, Razie Amraei, Ashley J. Mitchel, Nels Engblom and Catherine E. Costello
    Citation: Journal of Biomedical Science 2021 28:61
    Content type: Research Published on:

  11. Sequential infections with SARS-CoV-2 variants such as Alpha, Delta, Omicron and its sublineages may cause high morbidity, so it is necessary to develop vaccines that can protect against both wild-type (WT) vi...

    Authors: Monika Kumari, Shih-Chieh Su, Kang-Hao Liang, Hsiu-Ting Lin, Yu-Feng Lu, Kai-Chi Chen, Wan-Yu Chen and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:46
    Content type: Research Published on:

  12. mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high e...

    Authors: Yu-Shiuan Wang, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Joyce Pei-Yi Yuan, Jui-Ling Tsai and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:84
    Content type: Review Published on:

  13. The EV-A71 + EV-D68 bivalent vaccine generated considerable EV-A71- and EV-D68-specific IgG and IgA titres in the sera, nasal washes, saliva, bronchoalveolar lavage fluid, and feces. These antibodies neutralized ...

    Authors: Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan and Bor-Luen Chiang
    Citation: Journal of Biomedical Science 2023 30:96
    Content type: Research Published on:

  14. The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of...

    Authors: Paul Gutwein, Anja Schramme, Mohamed Sadek Abdel-Bakky, Kai Doberstein, Ingeborg A Hauser, Andreas Ludwig, Peter Altevogt, Stefan Gauer, Anja Hillmann, Thomas Weide, Christine Jespersen, Wolfgang Eberhardt and Josef Pfeilschifter
    Citation: Journal of Biomedical Science 2010 17:3
    Content type: Research Published on:

  15. Visfatin protein (2.55-fold) and mRNA (2.53-fold) expression were significantly increased after exposure to 2.5 ATA HBO for 4 to 6 h. Addition of SP600125 and JNK siRNA 30 min before HBO inhibited the induction o...

    Authors: Bao-Wei Wang, Chiu-Mei Lin, Gong-Jhe Wu and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2011 18:27
    Content type: Research Published on:

  16. Drosophila ktub...mutants were generated using imprecise excision. Wild type and mutant flies were raised in dark or constant light conditions. After a period of light stimulation, retinas were dissected, fixed a...

    Authors: Shu-Fen Chen, Yu-Chen Tsai and Seng-Sheen Fan
    Citation: Journal of Biomedical Science 2012 19:101
    Content type: Research Published on:

  18. The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early atherosclerosis. Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin...

    Authors: Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker and Lee-Young Chau
    Citation: Journal of Biomedical Science 2021 28:5
    Content type: Research Published on:

  19. Microarray and bioinformatics analysis of low and highly invasive ovarian cancer cell lines were used to reveal periostin (POSTN), a matrix protein with multifunctions in cancer, with elevated expression in the h...

    Authors: Sheng-Chieh Lin, Yi-Chu Liao, Po-Ming Chen, Ya-Yu Yang, Yi-Hsiang Wang, Shiao-Lin Tung, Chi-Mu Chuang, Yu-Wen Sung, Te-Hsuan Jang, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2022 29:109
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2023 30:54

  20. N-linked glycosylation is one of the most abundant posttranslational modifications of membrane-bound proteins in eukaryotes and affects a number of biological activities, including protein biosynthesis, protein.....

    Authors: Ying-Nai Wang, Heng-Huan Lee, Jennifer L. Hsu, Dihua Yu and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2020 27:77
    Content type: Review Published on:

  21. The replication and transcription activator (RTA) of Kaposi's sarcoma-associated herpesvirus (KSHV) is a molecular switch that initiates a productive replication of latent KSHV genomes. KSHV RTA (K-RTA) is com...

    Authors: Ying-Chieh Ko, Wan-Hua Tsai, Pei-Wen Wang, I-Lin Wu, Shu-Yu Lin, Yu-Lian Chen, Jen-Yang Chen and Su-Fang Lin
    Citation: Journal of Biomedical Science 2012 19:12
    Content type: Research Published on:

  22. Cholangiocarcinoma represents the second most common primary liver malignancy. The incidence rate has constantly increased over the last decades. Cholangiocarcinoma silent nature limits early diagnosis and pre...

    Authors: Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao and Jiansong Ji
    Citation: Journal of Biomedical Science 2021 28:44
    Content type: Research Published on:

  23. Unprecedented efforts of the researchers have been witnessed in the recent past towards the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit, vaccination stands as a practical str...

    Authors: Kunal Nepali, Ram Sharma, Sachin Sharma, Amandeep Thakur and Jing-Ping Liou
    Citation: Journal of Biomedical Science 2022 29:65
    Content type: Review Published on:

  24. On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as a pandemic. Like in all other infectious di...

    Authors: Feng-Yee Chang, Hsiang-Cheng Chen, Pei-Jer Chen, Mei-Shang Ho, Shie-Liang Hsieh, Jung-Chung Lin, Fu-Tong Liu and Huey-Kang Sytwu
    Citation: Journal of Biomedical Science 2020 27:72
    Content type: Review Published on:

  25. MALT1 belongs to a family of paracaspase and modulates NF-κB signaling pathways through its scaffolding function and proteolytic activity. MALT1 cleaves protein substrates after a positively charged Arginine r...

    Authors: Shin-Yi Jou, Chien-Chih Chang, Chun-Hsien Wu, Mei-Ru Chen, Ching-Hwa Tsai, Wen-Hui Chuang, Yun-Hui Chen, Ann-Lii Cheng and Shin-Lian Doong
    Citation: Journal of Biomedical Science 2012 19:85
    Content type: Research Published on:

  26. Microglial inflammation may significantly contribute to the pathology of Alzheimer’s disease. To examine the potential of Cudrania cochinchinensis to ameliorate amyloid β protein (Aβ)-induced microglia activation...

    Authors: Chung-Jen Wang, Chien-Chih Chen, Huey-Jen Tsay, Feng-Yi Chiang, Mine-Fong Wu and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:55
    Content type: Research Published on:

  27. Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being hi...

    Authors: Leili Aghebati-Maleki, Babak Bakhshinejad, Behzad Baradaran, Morteza Motallebnezhad, Ali Aghebati-Maleki, Hamid Nickho, Mehdi Yousefi and Jafar Majidi
    Citation: Journal of Biomedical Science 2016 23:66
    Content type: Review Published on:

  29. NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2), containing one iron sulfur cluster ([2Fe-2S] binuclear cluster N1a), is one of the core nuclear-encoded subunits existing in human mitochondrial complex...

    Authors: Hsin-Yu Liu, Pin-Chao Liao, Kai-Tun Chuang and Mou-Chieh Kao
    Citation: Journal of Biomedical Science 2011 18:29
    Content type: Research Published on:

  30. SDF-1 treatment induced adhesion of DLD-1 cells to the endothelium and increased the expression level of the ICAM-1. Inhibition of ICAM-1 by small interfering RNA (siRNA) and neutralizing antibody inhibited SDF-1...

    Authors: Shui-Yi Tung, Shun-Fu Chang, Ming-Hui Chou, Wen-Shih Huang, Yung-Yu Hsieh, Chien-Heng Shen, Hsing-Chun Kuo and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2012 19:91
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2013 20:21

  31. In endothelial cells, phospholipase C (PLC) β1-activated Ca2+ is a crucial second messenger for the signaling pathways governing angiogenesis. PLCβ1 is inactivated by complexing with an intracellular protein call...

    Authors: Sheng-Hung Wang, Jing-Yan Cheng, Hsiu-Hui Tsai, Tzu-Chi Lo, Jung-Tung Hung, Chun-Cheng Lin, Chien-Wei Lee, Yi-Hsuan Ho, Huan-Hsien Kuo, Alice L. Yu and John Yu
    Citation: Journal of Biomedical Science 2022 29:105
    Content type: Research Published on:

  32. The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian ...

    Authors: Chia-Hsun Fang, Yi-Te Lin, Chi-Ming Liang and Shu-Mei Liang
    Citation: Journal of Biomedical Science 2020 27:42
    Content type: Research Published on:

  34. The synthesized conjugate vaccines are characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and fast performance liquid chromatography (FPLC), and their contents of polysacchar...

    Authors: Tzu-Wei Chiu, Chi-Jiun Peng, Ming-Cheng Chen, Mei-Hua Hsu, Yi-Hua Liang, Cheng-Hsun Chiu, Jim-Min Fang and Yuan Chuan Lee
    Citation: Journal of Biomedical Science 2020 27:89
    Content type: Research Published on:

  35. Functional cooperation between FACT and the MCM helicase complex constitutes an integral step during DNA replication initiation. However, mode of regulation that underlies the proper functional interaction of ...

    Authors: Bertrand Chin-Ming Tan, Hsuan Liu, Chih-Li Lin and Sheng-Chung Lee
    Citation: Journal of Biomedical Science 2010 17:11
    Content type: Research Published on:

  36. Despite the recent development of safe and highly effective direct-acting antivirals, hepatitis C virus (HCV) infection remains a significant health problem. In 2016, the World Health Organization set out to redu...

    Authors: Daniel Sepulveda-Crespo, Salvador Resino and Isidoro Martinez
    Citation: Journal of Biomedical Science 2020 27:78
    Content type: Review Published on:

  37. Prostate smooth muscle tone is regulated by α1-adrenoceptor-induced contraction and cAMP-mediated relaxation. EPAC is an effector of cAMP, being involved in smooth muscle relaxation and cell cycle control outs...

    Authors: Martin Hennenberg, Frank Strittmatter, Henning Schmetkamp, Beata Rutz, Sebastian Walther, Christian G Stief and Christian Gratzke
    Citation: Journal of Biomedical Science 2013 20:46
    Content type: Research Published on:

  38. Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue hemorrhagic fever (DHF), associated with increased...

    Authors: Lisa J. Ioannidis, Stephanie I. Studniberg, Emily M. Eriksson, Suhendro Suwarto, Dionisius Denis, Yang Liao, Wei Shi, Alexandra L. Garnham, R. Tedjo Sasmono and Diana S. Hansen
    Citation: Journal of Biomedical Science 2023 30:24
    Content type: Research Published on:

  39. In Neisseria meningitidis the HrpA/HrpB two-partner secretion system (TPS) was implicated in diverse functions including meningococcal competition, biofilm formation, adherence to epithelial cells, intracellular ...

    Authors: Adelfia Talà, Flora Guerra, Matteo Calcagnile, Roberta Romano, Silvia Caterina Resta, Aurora Paiano, Mario Chiariello, Graziano Pizzolante, Cecilia Bucci and Pietro Alifano
    Citation: Journal of Biomedical Science 2022 29:45
    Content type: Research Published on:

  40. Studies have shown the existence of p21 induction in a p53-dependent and -independent pathway. Our previous study indicates that DOX-induced p65 is able to bind the p21 promoter to activate its transactivation...

    Authors: YingQi Zhou, Gang Li, Yuan Ji, Chen Liu, JingPing Zhu and YanJun Lu
    Citation: Journal of Biomedical Science 2012 19:15
    Content type: Research Published on:

  41. Opportunistically nosocomial infections in hospitalized patients are often related to Clostridium difficile...infections (CDI) due to disruption of the intestinal micro-flora by antibiotic therapies during hospit...

    Authors: Jui-Hsin Huang, Chia-Wei Wu, Shu-Pei Lien, Chih-Hsiang Leng, Kuang-Nan Hsiao, Shih-Jen Liu, Hsin-Wei Chen, Leung-Kei Siu and Pele Chong
    Citation: Journal of Biomedical Science 2015 22:65
    Content type: Research Published on:

  42. The inhibitory Fc receptor, FcγRIIB, has emerged as a key negative regulator of B cell activation and as such is predicted to play an essential role in controlling antibody-mediated autoimmune diseases in humans....

    Authors: Shiang-Jong Tzeng, Wan-Yu Li and Hui-Ying Wang
    Citation: Journal of Biomedical Science 2015 22:87
    Content type: Research Published on:

  43. The mechanism of Nova1’s role in hepatocellular carcinoma has not been delineated. Also its interaction with GABAA receptor γ2 in HCC is unveiled. This study is aimed to make it clear the distribution, prognostic...

    Authors: Yi-An Zhang, Hai-Ning Liu, Ji-Min Zhu, Dan-Ying Zhang, Xi-Zhong Shen and Tao-Tao Liu
    Citation: Journal of Biomedical Science 2016 23:71
    Content type: Research Published on:

  44. Cryptococcus neoformans has a predilection for central nervous system infection. C. neoformans traversal of the blood brain barrier, composed of human brain microvascular endothelial cells (HBMEC), is the crucial...

    Authors: Min Long, Sheng-He Huang, Chun-Hua Wu, Gregory M Shackleford and Ambrose Jong
    Citation: Journal of Biomedical Science 2012 19:19
    Content type: Research Published on:

  45. Dendritic spines, the actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain. Many actin-regulating molecules modulate dendritic spine morph...

    Authors: Hsiao-Tang Hu, Tzyy-Nan Huang and Yi-Ping Hsueh
    Citation: Journal of Biomedical Science 2020 27:103
    Content type: Research Published on:

  46. The roles of caspase 3 on the kainic acid-mediated neurodegeneration, dendritic plasticity alteration, neurogenesis, microglial activation and gliosis are not fully understood. Here, we investigate hippocampal...

    Authors: Tsai-Teng Tzeng, Huey-Jen Tsay, Luping Chang, Chia-Lin Hsu, Tzu-Hsuan Lai, Fong-Lee Huang and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:90
    Content type: Research Published on:

  47. Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making ...

    Authors: Jih-Jin Tsai, Kulkanya Chokephaibulkit, Po-Chih Chen, Li-Teh Liu, Hui-Mien Hsiao, Yu-Chih Lo and Guey Chuen Perng
    Citation: Journal of Biomedical Science 2013 20:88
    Content type: Review Published on:

  48. The AIRE protein plays a remarkable role as a regulator of central tolerance by controlling the promiscuous expression of tissue-specific antigens in thymic medullary epithelial cells. Defects in AIRE gene cau...

    Authors: Federica Incani, Maria Luisa Serra, Alessandra Meloni, Carla Cossu, Luisella Saba, Tiziana Cabras, Irene Messana and Maria Cristina Rosatelli
    Citation: Journal of Biomedical Science 2014 21:85
    Content type: Research Published on:

  49. Although the entry routes of the SARS-CoV-2 and the dengue virus (DENV) are different, both infections result in a systemic infection, with some similar clinical presentations such as fever, headache, myalgia and...

    Authors: Gathsaurie Neelika Malavige, Chandima Jeewandara and Graham S. Ogg
    Citation: Journal of Biomedical Science 2022 29:48
    Content type: Review Published on:

  50. Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator of airway fib...

    Authors: Hung-Sheng Hua, Heng-Ching Wen, Hong-Sheng Lee, Chih-Ming Weng, Fara Silvia Yuliani, Han-Pin Kuo, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2023 30:40
    Content type: Research Published on:
Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    11.0 - 2-year Impact Factor
    10.9 - 5-year Impact Factor
    2.367 - SNIP (Source Normalized Impact per Paper)
    2.520 - SJR (SCImago Journal Rank)

    2023 Speed
    14 days submission to first editorial decision for all manuscripts (Median)
    107 days submission to accept (Median)

    2023 Usage 
    1,698,723 downloads
    3,813 Altmetric mentions 

Journal of Biomedical Science

ISSN: 1423-0127