Journal of Biomedical Science is supported by the National Science and Technology Council (NSTC), Taiwan.
The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling
The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interacti...