Figure 1From: Recent advances in biomedical applications of accelerator mass spectrometrySchematic diagram of an accelerator mass spectrometry (AMS). Cesium (Cs) sputter ion source (A) contains the wheel with the graphite samples under high vacuum. Atomic Cs vapor is produced from a heated Cs reservoir and sprayed on to a heated ionizer surface, producing Cs+ ions that are accelerated towards the target held at -8 kV. The Cs+ ions sputter carbon atoms and ions from the target that are ionized to C- ions as they pass through a condensed Cs layer on the cathode. Negative ions at m/z 13 (13C-) and 14 (14C-) are pulsed through an injection magnet or low energy mass spectrometer (B) into a tandem electrostatic accelerator (C). Negative C- ions are accelerated towards the high-voltage terminal (+518 kV) in the center of the accelerator where they are converted to positive ions, C+ being the most abundant. The high-energy ion beam is focused to collide with argon gas electron stripper or a thin carbon foil, 0.02–0.05 μm thick (D) in a collision cell. Molecular charged ions such as 13CH- and 12CH2- do not survive the electron stripping process and are converted to atomic species, and 14N- ions decay on a femtosecond time-scale. The positive ions are repelled toward the high-energy exit of the accelerator held at 0 V. 13C+ and 14C+ ions are separated by momentum using a high-energy analyzing magnet or mass spectrometer (E). The beam currents of relatively abundant 12C and 13C are measured with Faraday cups (F). The 14C beam is focused by a quadruple and electrostatic cylinder analyzer and the atoms are counted in a gas ionization detector (G). The advantage of a gas ionization detector is that it measures energy loss in terms of ΔE/E which facilitates isotope separation. It is possible to optimize the detector to the energy-loss separation of the isotope.Back to article page