Sulforaphane attenuates EGFR signaling in NSCLC cells

Table 1 The IC50 of sulforaphane for human NSCLC cells harboring different EGFR mutations

^aCells were treated with various concentrations of sulforaphane for 48 h, and cell viability was determined by MTT assay. The IC50 values were calculated by non-linear regression analysis. Values are given as means ± standard deviation
^bL858R substitution in exon 21
^cPC9/gef is a gefitinib-resistant cell line that was selected from parental PC9 cells (which contain a deletion in exon 19 of EGFR) by continuous exposure to increasing doses of gefitinib over ~ 6 months
^dL858R substitution in exon 21 and a secondary T790M substitution in exon 20 of EGFR

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