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Table 1 Drugs of clinical trials for HR neuroblastoma interventetion

From: Neuroblastoma treatment in the post-genomic era

ClinicalTrials ID Original study Phase Status Referencea
NCT00026312 Isotretinoin With or Without Dinutuximab, Aldesleukin and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma phase III Completed Yu AL et al., 2010 [6]
NCT01704716 High Risk Neuroblastoma Study 1.7 of SIOP-Europe (SIOPEN) phase III Recruiting Dobrenkov K & Cheung NK, 2014 [7]
NCT01822652 3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN phase I Active, not recruiting Heczey A & Louis CU, 2013 [8]
NCT02395666 Preventative Trial of Difluoromethylornithine (DFMO) in High Risk Patients With Neuroblastoma That is in Remission Phase 2 Active, not recruiting Wallick CJ et al., 2005 [64]
NCT01586260 Preventative Trial of DFMO in Patients With High Risk Neuroblastoma in Remission Phase 2 Active, not recruiting Wallick CJ et al., 2005 [64]
NCT01059071 Safety Study for Refractory or Relapsed Neuroblastoma With DFMO Alone and in Combination With Etoposide Phase 1 Completed Wallick CJ et al., 2005 [64]
NCT02097810 Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1 or ALK Molecular Alterations phase I Recruiting Lee J et al., 2015 [83]
NCT01742286 Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK) phase I Recruiting Schulte JH et al., 2013 [69]
NCT01871805 A Study of CH5424802/RO5424802 in Patients With ALK-Rearranged Non-Small Cell Lung Cancer phase II Active, not recruiting McKeage K, 2015 [86]
NCT01049841 Perifosine With Temsirolimus for Recurrent Pediatric Solid Tumors phase I Active, not recruiting Rodrik-Outmezguine VS et al., 2011 [104]
NCT01767194 Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Phase 2 Recruiting Geoerger B et al., 2012 [105]
  1. a References are cited in review manuscript
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