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Fig. 8 | Journal of Biomedical Science

Fig. 8

From: Lipopolysaccharide pretreatment increases protease-activated receptor-2 expression and monocyte chemoattractant protein-1 secretion in vascular endothelial cells

Fig. 8

Schematic illustration of the proposed mechanism for infection-induced pathological responses. LPS pretreatment induced PAR-2 expression in vascular ECs. PAR-2 agonist (trypsin) potentiates PAR-2 activation and then calcium mobilization. The intracellular calcium activates the ERK/p38 MAPK pathway and leads to MCP-1 secretion

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