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Table 3 Non-Poliovirus Inhibitors

From: Recent advances on the role of host factors during non-poliovirus enteroviral infections

Drug compound Virus Mode of action Reference
Andrographolide EV-D68 Suppresses maturation of the virus within the acidic endosomes. [182]
DTriP EV-A71 Blocks viral replication by targeting the RNA dependent RNA polymerase. [195]
Ribavirin EV-A71 General reduction of the viral yield [179]
Quercetin EV-A71 Inhibits virus attachment, adsorption and the viral 3C protease [180]
Rupintrivir EV-A71, CV-A16, HRV Binds and inhibits viral 3C protease activity [196,197,198]
Fluoxetine CV-B3 Reduces synthesis of viral RNA and protein [199]
Dibucaine CV-B3, EV-D68, RNA replication stage; may be targeting CV-B3 viral 2C protease [184]
Formoterol CV-B3, EV-D68, EV-A71, RV-A2, RV-B14 Likely inhibit RV-14 by reducing ICAM-1 levels or acidic endosomes. [184, 200]
Pirlindole EV-D68 and CV-B3 RNA replication stage; may be targeting CV-B3 viral 2C protease  
Budesonide RV-14   [200]
Zuclopenthixol EV-D68 and CV-B3 RNA replication stage; may be targeting CV-B3 viral 2C protease [184]
Apigenin EV-A71 Targeting viral IRES thereby inhibiting viral translation process [191,192,193]