Recent advances on the role of host factors during non-poliovirus enteroviral infections

Table 3 Non-Poliovirus Inhibitors

Drug compound	Virus	Mode of action	Reference
Andrographolide	EV-D68	Suppresses maturation of the virus within the acidic endosomes.	[182]
DTriP	EV-A71	Blocks viral replication by targeting the RNA dependent RNA polymerase.	[195]
Ribavirin	EV-A71	General reduction of the viral yield	[179]
Quercetin	EV-A71	Inhibits virus attachment, adsorption and the viral 3C protease	[180]
Rupintrivir	EV-A71, CV-A16, HRV	Binds and inhibits viral 3C protease activity	[196,197,198]
Fluoxetine	CV-B3	Reduces synthesis of viral RNA and protein	[199]
Dibucaine	CV-B3, EV-D68,	RNA replication stage; may be targeting CV-B3 viral 2C protease	[184]
Formoterol	CV-B3, EV-D68, EV-A71, RV-A2, RV-B14	Likely inhibit RV-14 by reducing ICAM-1 levels or acidic endosomes.	[184, 200]
Pirlindole	EV-D68 and CV-B3	RNA replication stage; may be targeting CV-B3 viral 2C protease
Budesonide	RV-14		[200]
Zuclopenthixol	EV-D68 and CV-B3	RNA replication stage; may be targeting CV-B3 viral 2C protease	[184]
Apigenin	EV-A71	Targeting viral IRES thereby inhibiting viral translation process	[191,192,193]

ISSN: 1423-0127