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Table 3 Key patents covering phage-displayed antibody libraries

From: Development of therapeutic antibodies for the treatment of diseases

PatentTitleCompanyDate filedDate grantedDate of expiry
US5223409Directed evolution of novel binding proteinsDyax03/01/199106/29/19936/29/2010
US5885793Production of anti-self antibodies from antibody segment repertoires and displayed on phageCambridge Antibody Technology (CAT, now Medimmune)12/02/199203/23/19993/23/2016
US6582915Production of anti-self bodies from antibody segment repertories and displayed on phageCambridge Antibody Technology (CAT, now Medimmune)11/28/200006/24/200309/23/2012
US5969108Methods for producing members of specific binding pairsCambridge Antibody Technology (CAT, now Medimmune)07/10/199110/19/199910/19/2016
US6172197Methods for producing members of specific binding pairsCambridge Antibody Technology (CAT, now Medimmune)06/07/199501/09/200101/09/2018
US5821047Monovalent phage displayGenentech6/5/199510/13/199810/13/2015
US6706484Protein/(poly) peptide libraries (HuCAL libraries)Morphosys AG01/24/200003/16/200408/19/2016
US6753136Methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds (HuCAL GOLD libraries)Morphosys AG03/15/200103/21/200202/06/2021