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Table 7 LncRNAs shown to be involved in the process of cardiac regeneration

From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases

LncRNA Target Physiological/pathological impact Mechanism involved
CAREL [119] MiR-296 Repress the cardiac regeneration and differentiation A sponge for miR-296, repress miRNA-296, following by activate Trp53inp1 and Itm2a
CPR [120, 121] DNMT3A Induce cardiac hypertrophic response instead of the CM proliferation Interact with DNMT3A to repress the level or MCM3
NR_045363 [122] MiR-216a Activate neonatal cardiac regeneration Promote JAK2/STAT3 signaling pathway
CRRL [123] MiR-199a-3p Regulating CM proliferation Protect Hopx from degeneration of CRRL
ECRAR [124]   Modulated CM proliferation and post-MI rehabilitation without causing hypertrophy Promote the expression of cyclin D1, cyclin E1, and E2F1 proteins via ERK1/2 pathway
Sirt1 antisense lncRNA [127] Sirt1 mRNA Trigger the cardiac regeneration Deacetylated and inhibited the activity of Nkx2.5, stabilized and increase the Sirt1 mRNA expression
AZIN2-sv [128] MiR-214 Stimulate CM proliferation Increase the level of PTEN and inhibit Akt/PKB signaling pathway