Table 7 LncRNAs shown to be involved in the process of cardiac regeneration
From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases
LncRNA | Target | Physiological/pathological impact | Mechanism involved |
|---|---|---|---|
CAREL [119] | MiR-296 | Repress the cardiac regeneration and differentiation | A sponge for miR-296, repress miRNA-296, following by activate Trp53inp1 and Itm2a |
DNMT3A | Induce cardiac hypertrophic response instead of the CM proliferation | Interact with DNMT3A to repress the level or MCM3 | |
NR_045363 [122] | MiR-216a | Activate neonatal cardiac regeneration | Promote JAK2/STAT3 signaling pathway |
CRRL [123] | MiR-199a-3p | Regulating CM proliferation | Protect Hopx from degeneration of CRRL |
ECRAR [124] | Â | Modulated CM proliferation and post-MI rehabilitation without causing hypertrophy | Promote the expression of cyclin D1, cyclin E1, and E2F1 proteins via ERK1/2 pathway |
Sirt1 antisense lncRNA [127] | Sirt1 mRNA | Trigger the cardiac regeneration | Deacetylated and inhibited the activity of Nkx2.5, stabilized and increase the Sirt1 mRNA expression |
AZIN2-sv [128] | MiR-214 | Stimulate CM proliferation | Increase the level of PTEN and inhibit Akt/PKB signaling pathway |