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  1. Our previous studies demonstrated that S100A16 promotes adipogenesis and is involved in weight gain attenuation induced by dietary calcium. Till now, the function of S100A16 in the breast cancer remains to be ...

    Authors: Wenbin Zhou, Hong Pan, Tiansong Xia, Jinqiu Xue, Lin Cheng, Ping Fan, Yifen Zhang, Weidong Zhu, Yi Xue, Xiaoan Liu, Qiang Ding, Yun Liu and Shui Wang
    Citation: Journal of Biomedical Science 2014 21:97
    Content type: Research Published on:

  2. Progressive micro-vascular vaso-degeneration is the major factor in progression of diabetic complications. Adrenomedullin (AM) and basic-Fibroblast growth factor (b-FGF) are strongly correlated with angiogenes...

    Authors: Fawziah A Alrouq, Abeer A Al-Masri, Laila M AL-Dokhi, Khalid A Alregaiey, Nervana M Bayoumy and Faten A Zakareia
    Citation: Journal of Biomedical Science 2014 21:94
    Content type: Research Published on:

  3. Two mature miRNA species may be generated from the 5’ and 3’ arms of a pre-miRNA precursor. In most cases, only one species remains while the complementary species is degraded. However, co-existence of miRNA-5...

    Authors: Kong Bung Choo, Yuen Loon Soon, Phan Nguyen Nhi Nguyen, Michele Sook Yuin Hiew and Chiu-Jung Huang
    Citation: Journal of Biomedical Science 2014 21:95
    Content type: Research Published on:

  4. The reported efficiency of differentiation of human bone marrow derived Mesenchymal Stem Cells (hBM MSC) into dopaminergic neurons with different inducers is found to vary. Thus, in the current study we have i...

    Authors: Sushmita Bose Nandy, Sujata Mohanty, Manisha Singh, Madhuri Behari and Balram Airan
    Citation: Journal of Biomedical Science 2014 21:83
    Content type: Research Published on:

  5. The evaluation of the clinical effects of Tacrine has shown efficacy in delaying the deterioration of the symptoms of Alzheimer's disease, while confirming the adverse events consisting mainly in the elevated ...

    Authors: Kai Y Wong, Andrew G Mercader, Laura M Saavedra, Bahareh Honarparvar, Gustavo P Romanelli and Pablo R Duchowicz
    Citation: Journal of Biomedical Science 2014 21:84
    Content type: Research Published on:

  6. The functions of free radicals on the effects of insulin that result in protection against cerebral ischemic insult in diabetes remain undefined. This present study aims to explain the contradiction among nitr...

    Authors: Li-Man Hung, Jiung-Pang Huang, Jiuan-Miaw Liao, Meng-Hsuan Yang, Dai-Er Li, Yuan-Ji Day and Shiang-Suo Huang
    Citation: Journal of Biomedical Science 2014 21:92
    Content type: Research Published on:

  7. Ampicillin-resistant S. aureus (ARSA) now poses a serious problem for hospitalized patients, and their care providers. Plant-derived antibacterial that can reverse the resistance to well-tried agents which have l...

    Authors: Yothin Teethaisong, Nongluk Autarkool, Kittipot Sirichaiwetchakoon, Pongrit Krubphachaya, Sajeera Kupittayanant and Griangsak Eumkeb
    Citation: Journal of Biomedical Science 2014 21:90
    Content type: Research Published on:

  8. Arecoline, a major alkaloid in Areca nut has the ability to induce oxidative stress. The effect of Areca nut, arecoline on reducing sperm quality and quantity were documented previously using several animal mo...

    Authors: Tzer-Min Kuo, Shun-Yuan Luo, Shang-Lun Chiang, Chi-Pin Lee, Yu-Fan Liu, Jan-Gowth Chang, Ming-Hsui Tsai and Ying-Chin Ko
    Citation: Journal of Biomedical Science 2014 21:93
    Content type: Research Published on:

  9. Mutation in the Wiskott-Aldrich syndrome Protein (WASP) causes Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopenia (XLT) and X-linked congenital neutropenia (XLN). The majority of missense mutations caus...

    Authors: Neeraj Jain, Jun Hou Tan, Shijin Feng, Bhawana George and Thirumaran Thanabalu
    Citation: Journal of Biomedical Science 2014 21:91
    Content type: Research Published on:

  10. The ATP-binding cassette transporter B1 (ABCB1) gene codes for a membrane efflux pump localized in epithelial cells. Together with other Permeability-glycoproteins in the small and large intestine, its product re...

    Authors: Marcella Martinelli, Luca Scapoli, Francesca Cura, Maria Teresa Rodia, Giampaolo Ugolini, Isacco Montroni and Rossella Solmi
    Citation: Journal of Biomedical Science 2014 21:89
    Content type: Research Published on:

  11. Lipid accumulation is the primary evidence of non-alcoholic fatty liver disease (NAFLD). Ginkgo biloba extract (GBE) and its flavonoid ingredients (quercetin, kaempferol, and isorhamnetin) could lessen the lipid ...

    Authors: Ting Wei, Fei-fei Xiong, Shi-dong Wang, Ke Wang, Yong-yu Zhang and Qing-hua Zhang
    Citation: Journal of Biomedical Science 2014 21:87
    Content type: Research Published on:

  12. Genome-wide association studies have been successful in identifying common genetic variants for human diseases. However, much of the heritable variation associated with diseases such as Parkinson's disease rem...

    Authors: Ying-Chao Lin, Ai-Ru Hsieh, Ching-Lin Hsiao, Shang-Jung Wu, Hui-Min Wang, Ie-Bin Lian and Cathy SJ Fann
    Citation: Journal of Biomedical Science 2014 21:88
    Content type: Research Published on:

  13. Calcium oxalate (CaOx) is the major constituent of about 75% of all urinary stone and the secondary hyperoxaluria is a primary risk factor. Current treatment options for the patients with hyperoxaluria and CaO...

    Authors: Ponnusamy Sasikumar, Sivasamy Gomathi, Kolandaswamy Anbazhagan, Albert Abhishek, Eldho Paul, Varadaraj Vasudevan, Sundaresan Sasikumar and Govindan Sadasivam Selvam
    Citation: Journal of Biomedical Science 2014 21:86
    Content type: Research Published on:

  14. The AIRE protein plays a remarkable role as a regulator of central tolerance by controlling the promiscuous expression of tissue-specific antigens in thymic medullary epithelial cells. Defects in AIRE gene cau...

    Authors: Federica Incani, Maria Luisa Serra, Alessandra Meloni, Carla Cossu, Luisella Saba, Tiziana Cabras, Irene Messana and Maria Cristina Rosatelli
    Citation: Journal of Biomedical Science 2014 21:85
    Content type: Research Published on:

  15. The membrane-proximal external region (MPER) of HIV-1 gp41 is particularly conserved and target for the potent broadly neutralizing monoclonal antibodies (bnMAbs) 2F5, 4E10 and 10E8. Epitope focusing and stabi...

    Authors: Thomas D Benen, Paul Tonks, Alexander Kliche, Ruth Kapzan, Jonathan L Heeney and Ralf Wagner
    Citation: Journal of Biomedical Science 2014 21:79
    Content type: Research Published on:

  16. Pin1 promotes oncogenesis by regulating multiple oncogenic signaling. In this study, we investigated the involvement of Pin1 in tumor progression and in the prognosis of human esophageal squamous cell carcinom...

    Authors: Forn-Chia Lin, Yu-Cheng Lee, Yih-Gang Goan, Chen-Hsun Tsai, Yun-Chin Yao, Hui-Chuan Cheng, Wu-Wei Lai, Yi-Ching Wang, Bor-Shyang Sheu and Pei-Jung Lu
    Citation: Journal of Biomedical Science 2014 21:75
    Content type: Research Published on:

  17. We previously reported that Enterovirus 71 (EV71) infection activates autophagy, which promotes viral replication both in vitro and in vivo. In the present study we further investigated whether EV71 infection of ...

    Authors: Ying-Ray Lee, Po-Shun Wang, Jen-Ren Wang and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2014 21:80
    Content type: Research Published on:

  18. Carbonic anhydrase VI (CA VI) is a secretory isozyme of the α-CA gene family. It is highly expressed in the salivary and mammary glands and secreted into saliva and milk. Although CA VI was first described as ...

    Authors: Maarit Patrikainen, Peiwen Pan, Natalia Kulesskaya, Vootele Voikar and Seppo Parkkila
    Citation: Journal of Biomedical Science 2014 21:82
    Content type: Research Published on:

  19. Mesenchymal stem cells (MSCs) at maternal-fetal interface are considered to play an important role in the pathogenesis of pre-eclampsia (PE). microRNAs (miRNAs) also have an important influence on differentiat...

    Authors: Guangfeng Zhao, Xue Zhou, Shiwen Chen, Huishuang Miao, Hongye Fan, Zhiqun Wang, Yali Hu and Yayi Hou
    Citation: Journal of Biomedical Science 2014 21:81
    Content type: Research Published on:

  20. The green fluorescence protein (GFP)-associated fluorescence method and the luciferase-associated bioluminescence method are the two major methods for IVIS imaging system to investigate the bacterial infection...

    Authors: Yao-Kuang Huang, Chishih Chu, Chih-Hsiung Wu, Chyi-Liang Chen and Cheng-Hsun Chiu
    Citation: Journal of Biomedical Science 2014 21:78
    Content type: Research Published on:

  23. Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. Few studies are available that describe this association with bladder cancer either related or unrelated to ...

    Authors: Fathia El-Sharkawi, Mahmoud El Sabah, Zeinab Hassan and Hussein Khaled
    Citation: Journal of Biomedical Science 2014 21:72
    Content type: Research Published on:

  24. Our previous study showed NF-κB repressing factor (NKRF) downregulates IP-10 and IL-8 synthesis in the peripheral blood mononuclear cells and alveolar macrophages of TB patients with high bacterial loads. Howe...

    Authors: Kuo-Hsiung Huang, Chun-Hua Wang, Chien-Huang Lin and Han-Pin Kuo
    Citation: Journal of Biomedical Science 2014 21:71
    Content type: Research Published on:

  25. Reperfusion after resuscitation from cardiac arrest (CA) is an event that increases reactive oxygen species production leading to oxidative stress. More specifically, myocardial oxidative stress may play a rol...

    Authors: Fernanda Schäfer Hackenhaar, Francesca Fumagalli, Giovanni Li Volti, Valeria Sorrenti, Ilaria Russo, Lidia Staszewsky, Serge Masson, Roberto Latini and Giuseppe Ristagno
    Citation: Journal of Biomedical Science 2014 21:70
    Content type: Research Published on:

  26. Aberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer. In this study, we decided to identify pro...

    Authors: Nader Mansour Samaei, Yaghoub Yazdani, Reza Alizadeh-Navaei, Hossein Azadeh and Touraj Farazmandfar
    Citation: Journal of Biomedical Science 2014 21:73
    Content type: Research Published on:

  27. Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring eff...

    Authors: Rita U Ostrovskaya, Yulia V Vakhitova, Uliyana Sh Kuzmina, Milyausha Kh Salimgareeva, Liana F Zainullina, Tatiana A Gudasheva, Vener A Vakhitov and Sergey B Seredenin
    Citation: Journal of Biomedical Science 2014 21:74
    Content type: Research Published on:

  28. The DEP domain is a globular domain containing approximately 90 amino acids, which was first discovered in 3 proteins: Drosophila disheveled, Caenorhabditis elegans EGL-10, and mammalian Pleckstrin; hence the ter...

    Authors: Ying-Fang Su, Chi-Yen Liang, Chih-Yang Huang, Chih-Yu Peng, Claire Chiyu Chen, Ming-Cheng Lin, Rong-Kai Lin, Wei-Wen Lin, Ming-Yung Chou, Pao-Hsin Liao and Jaw-Ji Yang
    Citation: Journal of Biomedical Science 2014 21:67
    Content type: Research Published on:

  29. Type I Bartter syndrome is a recessive human nephropathy caused by loss-of-function mutations in the SLC12A1 gene coding for the Na+-K+-2Cl− cotransporter NKCC2. We recently established the mutant mouse line Slc1...

    Authors: Elisabeth Kemter, Birgit Rathkolb, Lore Becker, Ines Bolle, Dirk H Busch, Claudia Dalke, Ralf Elvert, Jack Favor, Jochen Graw, Wolfgang Hans, Boris Ivandic, Svetoslav Kalaydjiev, Thomas Klopstock, Ildikó Rácz, Jan Rozman, Anja Schrewe…
    Citation: Journal of Biomedical Science 2014 21:68
    Content type: Research Published on:

  30. Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In th...

    Authors: Alireza Tahamtan, Amir Ghaemi, Ali Gorji, Hamid R Kalhor, Azadeh Sajadian, Alijan Tabarraei, Abdolvahab Moradi, Fatemeh Atyabi and Mishar Kelishadi
    Citation: Journal of Biomedical Science 2014 21:69
    Content type: Research Published on:

  31. Enzyme prodrug therapy shows promise for the treatment of solid tumors, but current approaches lack effective/safe delivery strategies. To address this, we previously developed three enzyme-containing fusion p...

    Authors: Katrin P Guillen, Carla Kurkjian and Roger G Harrison
    Citation: Journal of Biomedical Science 2014 21:65
    Content type: Research Published on:

  32. Methionine, an essential amino acid, is required for protein synthesis and normal cell metabolism. The transmethylation pathway and methionine salvage pathway (MTA cycle) are two major pathways regulating meth...

    Authors: He-Yen Chou, Yu-Hung Lin, Guan-Lin Shiu, Hsiang-Yu Tang, Mei-Ling Cheng, Ming-Shi Shiao and Li-Mei Pai
    Citation: Journal of Biomedical Science 2014 21:64
    Content type: Research Published on:

  33. Snake venoms are a complex mixture of active principles mainly peptides and proteins also including amino acids, nucleotides, free lipids, carbohydrates and metallic elements bound to proteins that interfere i...

    Authors: Mukunda Chethankumar and Leela Srinivas
    Citation: Journal of Biomedical Science 2014 21:66
    Content type: Research Published on:

  34. Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. Among them, Nek1 is the primary protein inactivated in kat2J mo...

    Authors: Yumay Chen, Huai-Chin Chiang, Patricia Litchfield, Michelle Pena, Charity Juang and Daniel J Riley
    Citation: Journal of Biomedical Science 2014 21:63
    Content type: Research Published on:

  35. Acute spinal cord injury (SCI) leads to a series of reactive changes and causes severe neurological deficits. A pronounced inflammation contributes to secondary pathology after SCI. Astroglia respond to SCI by...

    Authors: Fan-Wei Tseng, Dann-Ying Liou, May-Jywan Tsai, Wen-Cheng Huang and Henrich Cheng
    Citation: Journal of Biomedical Science 2014 21:60
    Content type: Research Published on:

  36. Opioids have been used for the management of pain and coadministration of two opioids may induce synergism. In a model of tonic pain, the acetic acid writhing test and in a phasic model, the hot plate, the ant...

    Authors: Hugo F Miranda, Viviana Noriega, Pilar Zanetta, Juan Carlos Prieto, Juan Carlos Prieto-Rayo, Nicolás Aranda and Fernando Sierralta
    Citation: Journal of Biomedical Science 2014 21:62
    Content type: Research Published on:

  37. Caffeic acid phenethyl ester (CAPE), a component of propolis, is reported to possess anti-inflammatory, anti-bacterial, anti-viral, and anti-tumor activities. Previously, our laboratory demonstrated the in vitro ...

    Authors: Tsui-Hwa Tseng, Chien-Heng Shen, Wen-Shih Huang, Cheng-Nan Chen, Wen-Hai Liang, Tseng-Hsi Lin and Hsing-Chun Kuo
    Citation: Journal of Biomedical Science 2014 21:61
    Content type: Research Published on:

  38. Stromal cell-derived factor-1 (SDF-1) (CXC chemokine ligand-12)/CXC chemokine receptor 4 (CXCR4) is involved in the carcinogenesis of human gastric cancer, where it stimulates angiogenesis and favors metastasi...

    Authors: Yung-Yu Hsieh, Chien-Heng Shen, Wen-Shih Huang, Chih-Chien Chin, Yi-Hung Kuo, Meng Chiao Hsieh, Hong-Ren Yu, Te-Sheng Chang, Tseng-Hsi Lin, Yung-Wei Chiu, Cheng-Nan Chen, Hsing-Chun Kuo and Shui-Yi Tung
    Citation: Journal of Biomedical Science 2014 21:59
    Content type: Research Published on:

  39. Sudden cardiac death (SCD) is the clinical outcome of a lethal arrhythmia that can develop on the background of unrecognized channelopathies or cardiomyopathies. Several susceptibility genes have been identifi...

    Authors: Vincenzo Lariccia, Annamaria Assunta Nasti, Federica Alessandrini, Mauro Pesaresi, Santo Gratteri, Adriano Tagliabracci and Salvatore Amoroso
    Citation: Journal of Biomedical Science 2014 21:58
    Content type: Research Published on:

  40. In congestive heart failure the balance between cell death and cell survival in cardiomyocytes is compromised. Sirtuin 1 (Sirt1) activates cell survival machinery and has been shown to be protective against is...

    Authors: Tse-Min Lu, Jia-Yun Tsai, Yen-Chung Chen, Chun-Yang Huang, Hung-Lung Hsu, Chi-Feng Weng, Chun-Che Shih and Chiao-Po Hsu
    Citation: Journal of Biomedical Science 2014 21:57
    Content type: Research Published on:

  41. Epigallocatechin-3-gallate (EGCG) has been documented for its beneficial effects protecting oxidative stress to cardiac cells. Previously, we have shown the EGCG-mediated cardiac protection by attenuating reac...

    Authors: Wei-Cheng Chen, Shih-Rong Hsieh, Chun-Hwei Chiu, Ban-Dar Hsu and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2014 21:56
    Content type: Research Published on:

  42. Adipose tissue provides a readily available source of autologous stem cells. Adipose-derived stem cells (ASCs) have been proposed as a source for endothelial cell substitutes for lining the luminal surface of ...

    Authors: Divya Arya, Shaohua Chang, Paul DiMuzio, Jeffrey Carpenter and Thomas N Tulenko
    Citation: Journal of Biomedical Science 2014 21:55
    Content type: Research Published on:

  43. A new highly pathogenic human coronavirus (CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in Jeddah and Saudi Arabia and quickly spread to some European countries since September 20...

    Authors: Min-Han Lin, Shang-Ju Chuang, Chiao-Che Chen, Shu-Chun Cheng, Kai-Wen Cheng, Chao-Hsiung Lin, Chiao-Yin Sun and Chi-Yuan Chou
    Citation: Journal of Biomedical Science 2014 21:54
    Content type: Research Published on:

  44. Hairy and Enhancer of split 1 (Hes-1) is a transcriptional repressor that plays an important role in neuronal differentiation and development, but post-translational modifications of Hes-1 are much less known. In...

    Authors: Hsin-Ying Clair Chiou, Shau-Yu Liu, Cheng-Hsiung Lin and Eminy HY Lee
    Citation: Journal of Biomedical Science 2014 21:53
    Content type: Research Published on:

  46. Cancer immunoediting is a dynamic process composed of three phases: elimination (EL), equilibrium (EQ) and escape (ES) that encompasses the potential host-protective and tumor-sculpting functions of the immune...

    Authors: Lucas Pagura, Juan Manuel Cáceres, Albertina Cardinale, Olga Graciela Scharovsky, Ricardo José Di Masso, Mariano Federico Zacarías-Fluck, María José Rico and Viviana Rosa Rozados
    Citation: Journal of Biomedical Science 2014 21:52
    Content type: Research Published on:

  47. Excessive manganese exposure induced cognitive deficit. Several lines of evidence have demonstrated that taurine improves cognitive impairment induced by numerous neurotoxins. However, the role of taurine on m...

    Authors: Cai-Ling Lu, Shen Tang, Zhi-Juan Meng, Yi-Yuan He, Ling-Yong Song, Yin-Pin Liu, Ning Ma, Xi-Yi Li and Song-Chao Guo
    Citation: Journal of Biomedical Science 2014 21:51
    Content type: Research Published on:

  48. Decay Accelerating Factor (DAF) and Coxsackievirus-Adenovirus Receptor (CAR) have been identified as cellular receptors for Coxsackie B viruses (CV-B). The aim of this study is to elucidate the different bindi...

    Authors: Samira Riabi, Rafik Harrath, Imed Gaaloul, Lamjed Bouslama, Dorsaf Nasri, Mahjoub Aouni, Sylvie Pillet and Bruno Pozzetto
    Citation: Journal of Biomedical Science 2014 21:50
    Content type: Research Published on:

  49. Among a variety of inflammatory mediators, visfatin is a proinflammatory adipocytokine associated with inflammatory reactions in obesity, metabolic syndrome, chronic inflammatory disease, and autoimmune diseas...

    Authors: Si-Youn Song, Eun Chae Jung, Chang Hoon Bae, Yoon Seok Choi and Yong-Dae Kim
    Citation: Journal of Biomedical Science 2014 21:49
    Content type: Research Published on:

  50. MicroRNAs have been implicated in cancer but studies on their role in precancer, such as leukoplakia, are limited. Sequence variations at eight miRNA and four miRNA processing genes were studied in 452 healthy...

    Authors: Roshni Roy, Navonil De Sarkar, Sandip Ghose, Ranjan R Paul, Anindita Ray, Indranil Mukhopadhyay and Bidyut Roy
    Citation: Journal of Biomedical Science 2014 21:48
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127