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  1. Tissue and organ regeneration via transplantation of cell bodies in-situ has become an interesting strategy in regenerative medicine. Developments of cell carriers to systematically deliver cell bodies in the ...

    Authors: Mohammod K Bhuyan, Jorge I Rodriguez-Devora, Kym Fraser and Tzu-Liang Bill Tseng
    Citation: Journal of Biomedical Science 2014 21:47
    Content type: Research Published on:

  2. Intermittent hypoxia (IH) plays a critical role in sleep breathing disorder-associated hippocampus impairments, including neurocognitive deficits, irreversible memory and learning impairments. IH-induced neuro...

    Authors: Tsung-I Chen, Hung-Wen Chiu, Yi-Chung Pan, Shih-Ting Hsu, Jian-Hong Lin and Kun-Ta Yang
    Citation: Journal of Biomedical Science 2014 21:46
    Content type: Research Published on:

  3. Although runt-related transcription factor 2 (RUNX2) has been considered a determinant of cleidocranial dysplasia (CCD), some CCD patients were free of RUNX2 mutations. CCAAT/enhancer-binding protein beta (Ceb...

    Authors: Boyen Huang, Katsu Takahashi, Ernest A Jennings, Pongthorn Pumtang-on, Honoka Kiso, Yumiko Togo, Kazuyuki Saito, Manabu Sugai, Shizuo Akira, Akira Shimizu and Kazuhisa Bessho
    Citation: Journal of Biomedical Science 2014 21:44
    Content type: Research Published on:

  4. Spinal cord injury (SCI) deteriorates various physical functions, in particular, bladder problems occur as a result of damage to the spinal cord. Stem cell therapy for SCI has been focused as the new strategy ...

    Authors: Young-Sam Cho, Il-Gyu Ko, Sung-Eun Kim, Sung-Min Lee, Mal-Soon Shin, Chang-Ju Kim, Sang-Hoon Kim, Jun-Jang Jin and Khae-Hawn Kim
    Citation: Journal of Biomedical Science 2014 21:43
    Content type: Research Published on:

  6. As compared to cisplatin, trinuclear platinum compounds such as BBR3464 and DH6Cl have an altered spectrum of activity possibly because they form long-range adducts with DNA as against mainly intrastrand 1,2-b...

    Authors: Shahnaz A Hamad, Philip Beale, Jun Q Yu and Fazlul Huq
    Citation: Journal of Biomedical Science 2014 21:41
    Content type: Research Published on:

  7. p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation or inactivating interactions with viral or cellular proteins. The uncertainties around the link bet...

    Authors: James Yi-Hsin Chan, Ying-Chuan Chen, Shu-Ting Liu, Wei-Yuan Chou, Ching-Liang Ho and Shih-Ming Huang
    Citation: Journal of Biomedical Science 2014 21:40
    Content type: Research Published on:

  8. Riboflavin (RF) or vitamin B2 is known to have neuroprotective effects. In the present study, we report the attenuation of the neuroprotective effects of RF under UV-B irradiation. Preconditioning of UV-B irra...

    Authors: Amit Kumar Tripathi, Ashish Dwivedi, Manish Kumar Pal, Namrata Rastogi, Priyanka Gupta, Shakir Ali, Manjunatha Prabhu BH, Hari Narayan Kushwaha, Ratan Singh Ray, Shio Kumar Singh, Shivali Duggal, Bhaskar Narayan and Durga Prasad Mishra
    Citation: Journal of Biomedical Science 2014 21:39
    Content type: Research Published on:

  9. Reduction of pancreatic β-cells mass, major secondary to increased β-cells apoptosis, is increasingly recognized as one of the main contributing factors to the pathogenesis of type 2 diabetes (T2D), and satura...

    Authors: Shan Huang, Minghui Zhu, Wei Wu, Abid Rashid, Yan Liang, Ling Hou, Qin Ning and Xiaoping Luo
    Citation: Journal of Biomedical Science 2014 21:38
    Content type: Research Published on:

  10. An endogenous dopaminergic (DA) tone acting on D3 receptors has been shown to inhibit tuberoinfundibular (TI) DA neuron activity and stimulate prolactin (PRL) surge in the afternoon of estrogen-primed ovariectomi...

    Authors: Shu-Ling Liang, Sheng-Chieh Hsu and Jenn-Tser Pan
    Citation: Journal of Biomedical Science 2014 21:37
    Content type: Research Published on:

  11. H-rev107, also called HRASLS3 or PLA2G16, is a member of the HREV107 type II tumor suppressor gene family. Previous studies showed that H-rev107 exhibits phospholipase A/acyltransferase (PLA/AT) activity and d...

    Authors: Chun-Hua Wang, Rong-Yaun Shyu, Chang-Chieh Wu, Tzung-Chieh Tsai, Lu-Kai Wang, Mao-Liang Chen, Shun-Yuan Jiang and Fu-Ming Tsai
    Citation: Journal of Biomedical Science 2014 21:36
    Content type: Research Published on:

  12. The aim of this study was to develop the near infrared fluorescence (NIRF)-based imaging agent for the visualization of vascular endothelial growth factor (VEGF) in colon cancer. AlexaFluor 750 conjugating wit...

    Authors: Bishnuhari Paudyal, Pramila Paudyal, Dilip Shah, Hideyuki Tominaga, Yoshito Tsushima and Keigo Endo
    Citation: Journal of Biomedical Science 2014 21:35
    Content type: Research Published on:

  13. Coronavirus membrane (M) proteins are capable of interacting with nucleocapsid (N) and envelope (E) proteins. Severe acute respiratory syndrome coronavirus (SARS-CoV) M co-expression with either N or E is suff...

    Authors: Ying-Tzu Tseng, Shiu-Mei Wang, Kuo-Jung Huang and Chin-Tien Wang
    Citation: Journal of Biomedical Science 2014 21:34
    Content type: Research Published on:

  14. Clinical manifestations of enterovirus 71 (EV71) range from herpangina, hand-foot-and-mouth disease (HFMD), to severe neurological complications. Unlike the situation of switching genotypes seen in EV71 outbre...

    Authors: Sheng-Wen Huang, Hui-Li Cheng, Hsin-Yi Hsieh, Chia-Lun Chang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Ih-Jen Su and Jen-Ren Wang
    Citation: Journal of Biomedical Science 2014 21:33
    Content type: Research Published on:

  15. Membranous nephropathy (MN) is a common cause of nephrotic syndrome that may progress to end-stage renal disease (ESRD). The formation of MN involves the in situ formation of subepithelial immune deposits and lea...

    Authors: Chao-Wen Cheng, Li-Chien Chang, Tzu-Ling Tseng, Chia-Chao Wu, Yuh-Feng Lin and Jin-Shuen Chen
    Citation: Journal of Biomedical Science 2014 21:573
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2016 23:37

  17. Dioscin, a typical steroid saponin, is isolated from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright. It has estrogenic activity and many studies have also reported that dioscorea plants have an ...

    Authors: Chunfang Zhang, Jinyong Peng, Shan Wu, Yue Jin, Fan Xia, Changyuan Wang, Kexin Liu, Huijun Sun and Mozhen Liu
    Citation: Journal of Biomedical Science 2014 21:30
    Content type: Research Published on:

  18. The epithelial barrier dysfunction plays a critical role in the pathogenesis of a broad array of immune diseases. Alix protein is involved in the endolysosome system. This study aims to elucidate the role of A...

    Authors: Hao Yan, Haitao Yi, Lixin Xia, Zhenke Zhan, Weiyi He, Jijuan Cao, Ping-Chang Yang and Zhigang Liu
    Citation: Journal of Biomedical Science 2014 21:29
    Content type: Research Published on:

  20. Specific vulnerability and degeneration of the dopaminergic neurons in the substantia nigra pars compacta of the midbrain is the pathological hallmark of Parkinson’s disease. A number of transcription factors ...

    Authors: Kambiz N Alavian, Sharmin Jeddi, Sahar I Naghipour, Pegah Nabili, Pawel Licznerski and Travis S Tierney
    Citation: Journal of Biomedical Science 2014 21:27
    Content type: Review Published on:

  21. Thalassemias (Thal) are forms of inherited autosomal recessive blood disorders arising out of mutations in the chromosomes 11 or 16. These disorders lead to poor oxygen delivery to blood vessels and consequent...

    Authors: M S AlSalhi, Farjah H AlGahtani, S Devanesan, V Trinka Vijmasi, K Jeyaprakash, Abbas H AlSaeed and V Masilamani
    Citation: Journal of Biomedical Science 2014 21:26
    Content type: Research Published on:

  23. Numerous efforts have been made to elucidate the etiology and improve the treatment of lung cancer, but the overall five-year survival rate is still only 15%. Although cigarette smoking is the primary risk fac...

    Authors: Liang-Chuan Lai, Mong-Hsun Tsai, Pei-Chun Chen, Lee H Chen, Jen-Hao Hsiao, Shin-Kuang Chen, Tzu-Pin Lu, Jang-Ming Lee, Chung-Ping Hsu, Chuhsing K Hsiao and Eric Y Chuang
    Citation: Journal of Biomedical Science 2014 21:24
    Content type: Research Published on:

  24. Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease whose etiology remains largely unknown. The uncontrolled oxidative stress in SLE contributes to functional oxidative modifications of ce...

    Authors: Dilip Shah, Nidhi Mahajan, Sangita Sah, Swapan K Nath and Bishnuhari Paudyal
    Citation: Journal of Biomedical Science 2014 21:23
    Content type: Review Published on:

  26. Stem cell-fate is highly regulated by stem cell niche, which is composed of a distinct microenvironment, including neighboring cells, signals and extracellular matrix. Bone marrow-derived mesenchymal stem cell...

    Authors: Chun-Chun Cheng, Yen-Hua Lee, Shau-Ping Lin, Wei-Chun HuangFu and I-Hsuan Liu
    Citation: Journal of Biomedical Science 2014 21:21
    Content type: Research Published on:

  27. Upon lipopolysaccharide (LPS) stimulation, activation of both the Toll-like receptor 4 (TLR4) and phosphoinositide 3-kinase (PI3K) pathways serves to balance proinflammatory and anti-inflammatory responses. Al...

    Authors: Johnson Chia-Shen Yang, Shao-Chun Wu, Cheng-Shyuan Rau, Tsu-Hsiang Lu, Yi-Chan Wu, Yi-Chun Chen, Ming-Wei Lin, Siou-Ling Tzeng, Chia-Jung Wu and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2014 21:20
    Content type: Research Published on:

  28. The apoptosis machinery is a promising target against benign prostatic hyperplasia (BPH). Inhibitors of apoptosis proteins (IAPs) modulate apoptosis by direct inhibition of caspases. Serenoa Repens (SeR) may be c...

    Authors: Letteria Minutoli, Domenica Altavilla, Herbert Marini, Mariagrazia Rinaldi, Natasha Irrera, Gabriele Pizzino, Alessandra Bitto, Salvatore Arena, Sebastiano Cimino, Francesco Squadrito, Giorgio Ivan Russo and Giuseppe Morgia
    Citation: Journal of Biomedical Science 2014 21:19
    Content type: Research Published on:

  30. Cyclooxygenase-2(COX-2) overexpression promotes inflammation and tumorigenesis. COX-2 expression in response to diverse stimuli is tightly controlled to avoid persistent overexpression. 5-methoxyindole metabol...

    Authors: Kenneth K Wu, Huei-Hsuan Cheng and Tzu-Ching Chang
    Citation: Journal of Biomedical Science 2014 21:17
    Content type: Review Published on:

  31. Human enterovirus 71 (EV71) is an important pathogen caused large outbreaks in Asian-Pacific region with severe neurological complications and may lead to death in young children. Understanding of the etiologi...

    Authors: Piyada Linsuwanon, Jiratchaya Puenpa, Sheng-Wen Huang, Ya-Fang Wang, John Mauleekoonphairoj, Jen-Ren Wang and Yong Poovorawan
    Citation: Journal of Biomedical Science 2014 21:16
    Content type: Research Published on:

  32. Stroke is one of the leading causes of neuronal death. Sesamin is known for neuroprotection by its antioxidant and anti-inflammatory properties but it lacks blood–brain barrier (BBB) activity. A panel of sesam...

    Authors: Chien-Wei Hou, Yi-Ling Chen, Shih-Hsien Chuang, Jen-Shu Wang and Kee-Ching Jeng
    Citation: Journal of Biomedical Science 2014 21:15
    Content type: Research Published on:

  34. Excessive saturated fatty acids have been considered to be one of major contributing factors for the dysfunction of skeletal muscle cells as well as pancreatic beta cells, leading to the pathogenesis of type 2...

    Authors: Hyae Gyeong Cheon and Young Sik Cho
    Citation: Journal of Biomedical Science 2014 21:13
    Content type: Research Published on:

  36. Matrix metalloproteinase-9 (MMP-9) has been shown to be induced by cytokines including TNF-α and may contribute to bone inflammatory diseases. However, the mechanisms underlying MMP-9 expression induced by TNF...

    Authors: Chia-Lan Tsai, Wei-Chung Chen, Hsi-Lung Hsieh, Pei-Ling Chi, Li-Der Hsiao and Chuen-Mao Yang
    Citation: Journal of Biomedical Science 2014 21:12
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2015 22:20

  37. Oxidized LDL (oxLDL) is involved in the development of atherosclerotic heart disease through a mechanism that is not fully understood. In this study, we examined the role of malondialdehyde (MDA), an important...

    Authors: Tzu-Ching Yang, Yi-Jie Chen, Shwu-Fen Chang, Chu-Huang Chen, Po-Yuan Chang and Shao-Chun Lu
    Citation: Journal of Biomedical Science 2014 21:11
    Content type: Research Published on:

  38. Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit o...

    Authors: Masanobu Tsubaki, Makiko Komai, Tatsuki Itoh, Motohiro Imano, Kotaro Sakamoto, Hirotaka Shimaoka, Tomoya Takeda, Naoki Ogawa, Kenji Mashimo, Daiichiro Fujiwara, Junji Mukai, Katsuhiko Sakaguchi, Takao Satou and Shozo Nishida
    Citation: Journal of Biomedical Science 2014 21:10
    Content type: Research Published on:

  39. The increase in fructose ingestion has been linked to overdrive of sympathetic activity and hypertension associated with the metabolic syndrome. The premotor neurons for generation of sympathetic vasomotor act...

    Authors: Kay LH Wu, Chun-Ying Hung, Julie YH Chan and Chih-Wei Wu
    Citation: Journal of Biomedical Science 2014 21:8
    Content type: Research Published on:

  40. The occurrence of Congenital Heart Disease (CHD) is resulted from either genetic or environmental factors or the both. The CITED2 gene deletion or mutation is associated with the development of cardiac malform...

    Authors: Min Xu, Xiaoyun Wu, Yonggang Li, Xiaofei Yang, Jihua Hu, Min Zheng and Jie Tian
    Citation: Journal of Biomedical Science 2014 21:7
    Content type: Research Published on:

  41. Tolerance to the analgesic effect of opioids is a pharmacological phenomenon that occurs after their prolonged administration. It has been shown that morphine-induced tolerance is associated with apoptosis in ...

    Authors: Mozhdeh Sharifipour, Esmaeal Izadpanah, Bahram Nikkhoo, Samad Zare, Ali Abdolmaleki, Katayoun Hassanzadeh, Farshid Moradi and Kambiz Hassanzadeh
    Citation: Journal of Biomedical Science 2014 21:6
    Content type: Research Published on:

  42. Several lines of evidence have demonstrated that bone marrow-derived mesenchymal stem cells (BM-MSC) release bioactive factors and provide neuroprotection for CNS injury. However, it remains elusive whether BM...

    Authors: May-Jywan Tsai, Shen-Kou Tsai, Bo-Ruei Hu, Dann-Ying Liou, Shih-Ling Huang, Ming-Chao Huang, Wen-Cheng Huang, Henrich Cheng and Shiang-Suo Huang
    Citation: Journal of Biomedical Science 2014 21:5
    Content type: Research Published on:

  43. The Maillard reaction is a chemical reaction occurring between a reducing sugar and an amino acid, generally requiring thermal processing. Maillard reaction products (MRPs) have antioxidant, antimutagenic, and...

    Authors: Jung-Il Chae, RaHam Lee, JinHyoung Cho, JinTae Hong and Jung-Hyun Shim
    Citation: Journal of Biomedical Science 2014 21:4
    Content type: Research Published on:

  44. Hemodynamic shear stress, the blood flow-generated frictional force acting on the vascular endothelial cells, is essential for endothelial homeostasis under normal physiological conditions. Mechanosensors on e...

    Authors: Hsyue-Jen Hsieh, Ching-Ann Liu, Bin Huang, Anne HH Tseng and Danny Ling Wang
    Citation: Journal of Biomedical Science 2014 21:3
    Content type: Review Published on:

  45. Polycystic ovary syndrome (PCOS) is a state of altered steroid hormone production and activity. Chronic estrogen exposure or lack of progesterone due to ovarian dysfunction can result in endometrial hyperplasi...

    Authors: Xin Li, Yi Feng, Jin-Fang Lin, HÃ¥kan Billig and Ruijin Shao
    Citation: Journal of Biomedical Science 2014 21:2
    Content type: Review Published on:

  46. Patients with colorectal cancer (CRC) often develop liver metastases, in which case surgery is considered the only potentially curative treatment option. However, liver surgery is associated with a risk of isc...

    Authors: Shu-Fan Jiao, Kai Sun, Xiao-Jing Chen, Xue Zhao, Ning Cai, Yan-Jun Liu, Long-Mei Xu, Xian-Ming Kong and Li-Xin Wei
    Citation: Journal of Biomedical Science 2014 21:1
    Content type: Research Published on:

  47. The polymorphic species Candida albicans is the major cause of candidiasis in humans. The secreted aspartyl proteinases (Saps) of C. albicans, encoded by a family of 10 SAP genes, have been investigated as the vi...

    Authors: Leh-Miauh Buu and Yee-Chun Chen
    Citation: Journal of Biomedical Science 2013 20:101
    Content type: Research Published on:

  48. Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the key regulators of hypoxia/ischemia. MicroRNA-494 (miR-494) had cardioprotective effects against ischemia/reperfusion (I/R)-induced injury, but its functi...

    Authors: Guixiang Sun, Yanni Zhou, Hongsheng Li, Yingjia Guo, Juan Shan, Mengjuan Xia, Youping Li, Shengfu Li, Dan Long and Li Feng
    Citation: Journal of Biomedical Science 2013 20:100
    Content type: Research Published on:

  50. Obesity is an important risk factor for atrial fibrillation (AF). Leptin is an important adipokine. However, it is not clear whether leptin directly modulates the electrophysiological characteristics of atrial...

    Authors: Yung-Kuo Lin, Yao-Chang Chen, Jen-Hung Huang, Yenn-Jiang Lin, Shiang-Suo Huang, Shih-Ann Chen and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2013 20:94
    Content type: Research Published on:
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Journal of Biomedical Science

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