Journal of Biomedical Science is supported by the National Science and Technology Council (NSTC), Taiwan.
Articles
788 result(s) for 'cancer' within Journal of Biomedical Science
Page 1 of 16
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Citation: Journal of Biomedical Science 2023 30:7
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Correction to: EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex
An amendment to this paper has been published and can be accessed via the original article.
Citation: Journal of Biomedical Science 2020 27:100 -
Correction to: CircNOL10 suppresses breast cancer progression by sponging miR-767-5p to regulate SOCS2/JAK/STAT signaling
An amendment to this paper has been published and can be accessed via the original article.
Citation: Journal of Biomedical Science 2021 28:31 -
Erratum to: Tranilast enhances the anti-tumor effects of tamoxifen on human breast cancer cells in vitro
Citation: Journal of Biomedical Science 2013 20:89 -
Erratum to: CXC chemokine ligand 12/Stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1
Citation: Journal of Biomedical Science 2013 20:21 -
Correction: Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling
Citation: Journal of Biomedical Science 2023 30:54 -
A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK
In this study, we found that it was a guanine nucleotide exchange factor and induced both cell migration in a cultured embryonic fibroblast cell line and cell invasion in cancer cell lines; moreover, it was obser...
Citation: Journal of Biomedical Science 2014 21:67 -
Correction to: Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway
In the original publication of this article [1] the name of the fifth author is uncorrect. The correct name of the fifth author should be Wei-Chiao Chang rather than Wei-Chao Chang. The original publication ha...
Citation: Journal of Biomedical Science 2019 26:98 -
Correction to: Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy
After publication of this article [1], it was brought to our attention that there are some errors in the section of ‘Authors’ contributions’.
Citation: Journal of Biomedical Science 2019 26:54 -
Cancer-derived extracellular succinate: a driver of cancer metastasis
Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the mitochondrial matrix. It is a substrate of succinate dehydrogenase (SDH). Mutation of SDH subunits (SDHD and SDHB) in hereditary...
Citation: Journal of Biomedical Science 2022 29:93 -
The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy
Obesity is nowadays considered a pandemic which prevalence’s has been steadily increasingly in western countries. It is a dynamic, complex, and multifactorial disease which propitiates the development of several ...
Citation: Journal of Biomedical Science 2022 29:12 -
Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-κB and TGF-β2 signaling
Ovarian cancer has the highest mortality among gynecological cancers due to late diagnosis and lack of ... therapy. Although the study of interplay between cancer cells with their microenvironment is emerging, ho...
Citation: Journal of Biomedical Science 2022 29:109 -
A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer
Colorectal cancer (CRC) is a worldwide cancer with rising annual incidence. New medications for ... , fluorescent chemical probes have been developed for cancer imaging and therapy. Signal transducer and activato...
Citation: Journal of Biomedical Science 2022 29:20 -
Role of mitochondrial alterations in human cancer progression and cancer immunity
Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria are essential organelles responsible for ... Although the “Warburg effect,” in which cancer cells prefer aerobic glycolysis ...
Citation: Journal of Biomedical Science 2023 30:61 -
A transcriptomic pan-cancer signature for survival prognostication and prediction of immunotherapy response based on endothelial senescence
The microvascular endothelium inherently controls nutrient delivery, oxygen supply, and immune surveillance of malignant tumors, thus representing both biological prerequisite and therapeutic vulnerability in cancer
Citation: Journal of Biomedical Science 2023 30:21 -
Cross-talk between cancer cells and their neighbors via miRNA in extracellular vesicles: an emerging player in cancer metastasis
Cancer metastasis is the major cause of mortality in cancer cases and is responsible for cancer deaths. It is known that cancer cells communicate with surrounding microenvironmental cells, such ... cells, and end...
Citation: Journal of Biomedical Science 2019 26:7 -
The biochemical value of urinary metalloproteinases 3 and 9 in diagnosis and prognosis of bladder cancer in Egypt
Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. Few studies are available that describe this association with bladder cancer either related or unrelated to sch...
Citation: Journal of Biomedical Science 2014 21:72 -
CHD5 is down-regulated through promoter hypermethylation in gastric cancer
Nonhistone chromosomal proteins in concert with histones play important roles in the replication and repair of DNA and in the regulation of gene expression. The deregulation of these proteins can contribute to th...
Citation: Journal of Biomedical Science 2009 16:95 -
Aberrant NDRG1 methylation associated with its decreased expression and clinicopathological significance in breast cancer
Cancer cell differentiation is an important characteristic of ... of human cell differentiation and metastasis in various cancers. Changes in the status of methylation of ... not been studied in detail in human b...
Citation: Journal of Biomedical Science 2013 20:52 -
Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway
Rab GTPases function as modulators in intracellular transport. Rab5a, a member of the Rab subfamily of small GTPases, is an important regulator of vesicle traffic from the plasma membrane to early endosomes. Rece...
Citation: Journal of Biomedical Science 2011 18:58 -
MicroRNA: a prognostic biomarker and a possible druggable target for circumventing multidrug resistance in cancer chemotherapy
Multidrug resistance (MDR) is a major obstacle to successful cancer treatment. It is often associated with an ... miRNAs are well-known to be dysregulated in cancer, recent literature revealed that miRNA levels i...
Citation: Journal of Biomedical Science 2013 20:99 -
NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer
Breast cancer is the most diagnosed malignancy in women. ... the local and/or systemic level in breast cancer pathobiology, influencing its progression, metastatic potential ... the development of inflammatory di...
Citation: Journal of Biomedical Science 2021 28:26 -
MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells
Two mature miRNA species may be generated from the 5’ and 3’ arms of a pre-miRNA precursor. In most cases, only one species remains while the complementary species is degraded. However, co-existence of miRNA-5p a...
Citation: Journal of Biomedical Science 2014 21:95 -
Diagnosis of transition zone prostate cancer by multiparametric MRI: added value of MR spectroscopic imaging with sLASER volume selection
Current multiparametric MRI (mp-MRI) in routine clinical practice has poor-to-moderate diagnostic performance for transition zone prostate cancer. The aim of this study was to...1H magnetic resonance spectroscopi...
Citation: Journal of Biomedical Science 2021 28:54 -
Fasting to enhance Cancer treatment in models: the next steps
Short-term fasting (STF) is a technique to reduce nutrient intake for a specific period. Since metabolism plays a pivotal role in tumor progression, it can be hypothesized that STF can improve the efficacy of che...
Citation: Journal of Biomedical Science 2020 27:58 -
Regulation of autophagy by microRNAs in human breast cancer
Breast cancer is the most common solid cancer that affects female population globally. MicroRNAs ( ... miRNAs could modulate autophagy activity in human breast cancer cells, and these would influence human breast...
Citation: Journal of Biomedical Science 2021 28:21 -
LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer malignancy. Long non-coding RNAs (lncRNAs)...
Citation: Journal of Biomedical Science 2023 30:80 -
Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression
Sp1, an important transcription factor, is involved in the progression of various cancers. Our previous studies have indicated that Sp1 ... are increased in the early stage of lung cancer progression but decrease...
Citation: Journal of Biomedical Science 2022 29:3 -
A non-genetic engineering platform for rapidly generating and expanding cancer-specific armed T cells
Cancer-specific adoptive T cell therapy has achieved ... clinical treatments. However, the commercial production of cancer-specific T cells is often hampered by...
Citation: Journal of Biomedical Science 2023 30:35 -
JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells
Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. ... (PGE2)-induced cellular motility in human colon cancer cells.
Citation: Journal of Biomedical Science 2011 18:61 -
Significance of rs1271572 in the estrogen receptor beta gene promoter and its correlation with breast cancer in a southwestern Chinese population
To characterize single nucleotide polymorphisms (SNPs) within the promoter region of the estrogen receptor beta (ERβ) gene and to analyze the association of ERβ SNPs with susceptibility to breast cancer. Genotype...
Citation: Journal of Biomedical Science 2013 20:32 -
Expression of Nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells
We aimed to examine the expression level of Nucleophosmin (NPM1) protein in colon cancer tissues and to investigate the potential role...
Citation: Journal of Biomedical Science 2012 19:53 -
Clinical-grade cryopreserved doxorubicin-loaded platelets: role of cancer cells and platelet extracellular vesicles activation loop
Human platelets (PLT) and PLT-extracellular vesicles (PEV) released upon thrombin activation express receptors that interact with tumour cells and, thus, can serve as a delivery platform of anti-cancer agents. Dr...
Citation: Journal of Biomedical Science 2020 27:45 -
Therapeutic antibodies for the prevention and treatment of cancer
The developments of antibodies for cancer therapeutics have made remarkable success in recent ... action. With better understanding of mechanism of cancer progression and immune manipulation, recombinant formats ...
Citation: Journal of Biomedical Science 2024 31:6 -
Akt: a key transducer in cancer
Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinase i...
Citation: Journal of Biomedical Science 2022 29:76 -
Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Breast cancer is one of the most common malignancies ... major feature of the malignant transformation of breast cancer. Compared to normal cells, tumor cells ... applications of metabolism-regulating ncRNAs invo...
Citation: Journal of Biomedical Science 2024 31:25 -
Recent developments in epigenetic cancer therapeutics: clinical advancement and emerging trends
Epigenetic drug discovery field has evidenced significant advancement in the recent times. A plethora of small molecule inhibitors have progressed to clinical stage investigations and are being explored exhaustiv...
Citation: Journal of Biomedical Science 2021 28:27 -
Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?
The major concept of "oxidative stress" is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption of oxygen. The precise harmonization of oxidative ...
Citation: Journal of Biomedical Science 2022 29:74 -
Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer
Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (lncRN...
Citation: Journal of Biomedical Science 2022 29:104 -
Scaffold-based 3D cell culture models in cancer research
Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two ... cell culture systems. In 3D cell cultures, cancer cells are grown i...
Citation: Journal of Biomedical Science 2024 31:7 -
Validation of genome-wide association study-identified single nucleotide polymorphisms in a case-control study of pancreatic cancer from Taiwan
Due to differences in genetic background, it is unclear whether the genetic loci identified by the previous genome-wide association studies (GWAS) of pancreatic cancer also play significant roles in the developme...
Citation: Journal of Biomedical Science 2020 27:69 -
Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic met...
Citation: Journal of Biomedical Science 2022 29:83 -
Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction
The leading cause of cancer-related mortality worldwide is lung cancer, and its clinical outcome and prognosis are ... deacetylase enzyme, is a promising target for cancer therapy; however, the molecular mechanis...
Citation: Journal of Biomedical Science 2023 30:4 -
Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model
Hedgehog signalling has been implicated in prostate tumorigenesis in human subjects and mouse models, but its effects on transforming normal basal/stem cells toward malignant cancer stem cells remain poorly under...
Citation: Journal of Biomedical Science 2011 18:6 -
Dysregulation of MicroRNAs in cancer
MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either ... has been widely observed in different stages of cancer
Citation: Journal of Biomedical Science 2012 19:90 -
Bacteria in cancer therapy: a novel experimental strategy
Resistance to conventional anticancer therapies in patients with advanced solid tumors has prompted the need of alternative cancer therapies. Moreover, the success of novel cancer therapies depends on their selec...
Citation: Journal of Biomedical Science 2010 17:21 -
A mammary adenocarcinoma murine model suitable for the study of cancer immunoediting
Cancer immunoediting is a dynamic process composed of ... are useful tools for studying diseases such as cancer. The present study was designed to characterize...− and CBi/L inbred mice lines.
Citation: Journal of Biomedical Science 2014 21:52 -
Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells
Stanniocalcin-1(STC-1) is up-regulated in several cancers including gastric cancer. Evidences suggest that STC-1 is associated...
Citation: Journal of Biomedical Science 2011 18:39 -
Detection of vascular endothelial growth factor in colon cancer xenografts using bevacizumab based near infrared fluorophore conjugate
The aim of this study was to develop the near infrared fluorescence (NIRF)-based imaging agent for the visualization of vascular endothelial growth factor (VEGF) in colon cancer. AlexaFluor 750 conjugating with b...
Citation: Journal of Biomedical Science 2014 21:35 -
Role of SALL4 in the progression and metastasis of colorectal cancer
Human cancer cells resemble stem cells in expression signatures...
Citation: Journal of Biomedical Science 2013 20:6
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2022 Citation Impact
11.0 - 2-year Impact Factor
10.9 - 5-year Impact Factor
2.367 - SNIP (Source Normalized Impact per Paper)
2.520 - SJR (SCImago Journal Rank)2023 Speed
14 days submission to first editorial decision for all manuscripts (Median)
107 days submission to accept (Median)2023 Usage
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