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  1. Biomarkers for cardiometabolic risk (CMR) factors would be important tools to maximize the effectiveness of dietary interventions to prevent cardiovascular diseases. Thus, the aim of this work was to analyze s...

    Authors: Gabriela Alarcón, Julieta Roco, Analia Medina, Carina Van Nieuwenhove, Mirta Medina and Susana Jerez
    Citation: Journal of Biomedical Science 2016 23:13
    Content type: Research Published on:

  2. Recent studies reported the critical role of the intrauterine environment of a fetus in growth or the development of disease in adulthood. In this article we discussed the implications of salt restriction in g...

    Authors: Hiroe Sakuyama, Minami Katoh, Honoka Wakabayashi, Anthony Zulli, Peter Kruzliak and Yoshio Uehara
    Citation: Journal of Biomedical Science 2016 23:12
    Content type: Review Published on:

  3. Homeostasis of reactive oxygen species (ROS) in the skin is regulated by antioxidant defenses. The inflammatory states of skin diseases which range from acute rashes to chronic conditions are related to the le...

    Authors: Tsang-Pai Liu, Yi-Ping Chen, Chih-Ming Chou, Ting-Ting Chiu and Chien-Tsu Chen
    Citation: Journal of Biomedical Science 2016 23:11
    Content type: Research Published on:

  4. Glioblastoma multiforme (GBM) is the most lethal primary brain tumors which remains difficult to cure despite advances in surgery, radiotherapy and chemotherapy. Therefore, the development of new drug is urgen...

    Authors: Hsiao-Chieh Huang, Wei-Ting Liu, Kuo-Su Hua, Hui-Chi Hung, Jui-Ying Tsai, Sheng-Chu Kuo, Li-Jiau Huang and Po-Wu Gean
    Citation: Journal of Biomedical Science 2016 23:10
    Content type: Research Published on:

  5. PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. Loss or down-regulation of PTEN plays an important role in human cancers development. In this study,...

    Authors: Yaghoub Yazdani, Touraj Farazmandfar, Hossein Azadeh and Zeinab Zekavatian
    Citation: Journal of Biomedical Science 2016 23:9
    Content type: Research Published on:

  7. Ischemia and reperfusion (I/R) – induced injury has been described as one of the main factors that contribute to the observed morbidity and mortality in a variety of clinical entities, including myocardial inf...

    Authors: Marios–Konstantinos Tasoulis and Emmanuel E. Douzinas
    Citation: Journal of Biomedical Science 2016 23:7
    Content type: Review Published on:

  8. Developing brain is a major target for alcohol’s actions and neurological/functional abnormalities include microencephaly, reduced frontal cortex, mental retardation and attention-deficits. Previous studies ha...

    Authors: Amanjot Kaur Riar, Madhusudhanan Narasimhan, Mary Latha Rathinam, George I. Henderson and Lenin Mahimainathan
    Citation: Journal of Biomedical Science 2016 23:6
    Content type: Research Published on:

  9. Acetaminophen (APAP) overdose causes acute liver failure (ALF) in animals and humans via the rapid depletion of intracellular glutathione (GSH) and the generation of excess reactive oxygen species (ROS) that d...

    Authors: Yu-Jen Huang, Poda Chen, Chih-Yuan Lee, Sin-Yu Yang, Ming-Tsan Lin, Hsuan-Shu Lee and Yao-Ming Wu
    Citation: Journal of Biomedical Science 2016 23:5
    Content type: Research Published on:

  10. Increased circulating levels of endoglin+ endothelial microparticles (EMPs) have been identified in several cardiovascular disorders, related to severity. Endoglin is an auxilary receptor for transforming growth ...

    Authors: Daria Belik, Hilda Tsang, John Wharton, Luke Howard, Carmelo Bernabeu and Beata Wojciak-Stothard
    Citation: Journal of Biomedical Science 2016 23:4
    Content type: Research Published on:

  11. Granulocyte-colony stimulating factor (G-CSF) is a major regulator of the production and survival of neutrophils. Regulation of G-CSF expression is complex and occurs at both transcription and post-transcripti...

    Authors: Shwu-Fen Chang, Huai-Ci Li, Yu-Pei Huang, Wen-Ju Tasi, Yuan-Yi Chou and Shao-Chun Lu
    Citation: Journal of Biomedical Science 2016 23:3
    Content type: Research Published on:

  12. 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) is a potential anticancer drug that may activate soluble guanylyl cyclase (sGC) and increase the level of cyclic guanosine monophosphate (cGMP). The aim of...

    Authors: Leo Tsui, Shwu-Fen Chang, Hsiang-Po Huang, Tsorng-Harn Fong and I-Jong Wang
    Citation: Journal of Biomedical Science 2016 23:2
    Content type: Research Published on:

  13. Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder and is a common genetic cause of chronic renal failure in children and adults. The enzyme renin plays a key role in the RAAS cascade...

    Authors: Gnanasambandan Ramanathan, Ramprasad Elumalai, Soundararajan Periyasamy and Bhaskar V. K. S. Lakkakula
    Citation: Journal of Biomedical Science 2016 23:1
    Content type: Research Published on:

  14. This study aimed at developing nerve growth factor (NGF) mimetics that selectively activate specific biological signals and, as a result, lack the side effects of the full-length protein. Two dimeric dipeptide...

    Authors: Tatyana A. Gudasheva, Polina Yu Povarnina, Tatyana A. Antipova, Yulia N. Firsova, Mark A. Konstantinopolsky and Sergey B. Seredenin
    Citation: Journal of Biomedical Science 2015 22:106
    Content type: Research Published on:

  15. Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated im...

    Authors: Zhongzheng Guan, Bingtan Song, Fengjun Liu, Dong Sun, Kexin Wang and Hui Qu
    Citation: Journal of Biomedical Science 2015 22:107
    Content type: Research Published on:

  16. Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies. However, the hepatoprotection of caffeine and its mechanisms in zebrafish ...

    Authors: Xinchun Zheng, Wencong Dai, Xiaohui Chen, Kunyuan Wang, Wenqing Zhang, Li Liu and Jinlin Hou
    Citation: Journal of Biomedical Science 2015 22:105
    Content type: Research Published on:

  17. The specification of vein and the patterning of intersegmental vessels (ISV) controlled by transcription factor is not fully characterized. The orphan nuclear receptor Chicken ovalbumin upstream promoter trans...

    Authors: Ru-Fang Li, Ting-Yun Wu, Yu-Zheng Mou, Yi-Shan Wang, Chun-Lin Chen and Chang-Yi Wu
    Citation: Journal of Biomedical Science 2015 22:104
    Content type: Research Published on:

  18. Highly desaturated n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are synthesized by desaturases and elongase. They exert hepatoprotective effects ...

    Authors: Chih-Lun Cheng, Shin-Jie Huang, Chih-Lu Wu, Hong-Yi Gong, Chuian-Fu Ken, Shao-Yang Hu and Jen-Leih Wu
    Citation: Journal of Biomedical Science 2015 22:103
    Content type: Research Published on:

  19. Mutations in mitogen-activated protein kinase (MAPK) kinase 1 (MEK1) that occur during cell proliferation and tumor formation are well described. Information on the roles of MEK2 in these effects is still limi...

    Authors: Chih-Ming Chou, Yi-Chung Chen, San Su, Gen-Der Chen, Kai-Yun Huang, Huang-Wei Lien, Chang-Jen Huang and Chia-Hsiung Cheng
    Citation: Journal of Biomedical Science 2015 22:102
    Content type: Research Published on:

  20. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor expressed in many cell types, including osteoblasts, osteocytes, and osteoclasts. Nrf2 has been considered a master regulator of cyt...

    Authors: Yong-Xin Sun, Ai-Hua Xu, Yang Yang and Jiliang Li
    Citation: Journal of Biomedical Science 2015 22:101
    Content type: Review Published on:

  21. Growth arrest-specific 5 (GAS5) was reported to be implicated and aberrantly express in multiple cancers. However, the expression and mechanism of action of GAS5 were largely poor understood in endometrial car...

    Authors: Chen Guo, Wei-qi Song, Ping Sun, Lian Jin and Hong-yan Dai
    Citation: Journal of Biomedical Science 2015 22:100
    Content type: Research Published on:

  22. The H-RAS-like suppressor (HRASLS) subfamily consists of five enzymes (1–5) in humans and three (1, 3, and 5) in mice and rats that share sequence homology with lecithin:retinol acyltransferase (LRAT). All HRA...

    Authors: Emily B. Mardian, Ryan M. Bradley and Robin E. Duncan
    Citation: Journal of Biomedical Science 2015 22:99
    Content type: Review Published on:

  23. Notch may behave as an oncogene or a tumor suppressor gene in lung cancer cells. Notch receptor undergoes cleavage by enzymes, including γ-secretase, generating the active Notch intracellular domain (NICD). Th...

    Authors: Efstathia Giannopoulou, Achilleas Nikolakopoulos, Dimitra Kotsirilou, Angeliki Lampropoulou, Sofia Raftopoulou, Evangelia Papadimitriou, Achilleas D. Theocharis, Thomas Makatsoris, Konstantinos Fasseas and Haralabos P. Kalofonos
    Citation: Journal of Biomedical Science 2015 22:98
    Content type: Research Published on:

  24. Stem cells of intensely regenerative tissues are susceptible to cellular damage. Although the response to this process in hematopoietic stem cells (HSCs) is crucial, the mechanisms by which hematopoietic homeo...

    Authors: Marcella L. Porto, Bianca P. Rodrigues, Thiago N. Menezes, Sara L. Ceschim, Dulce E. Casarini, Agata L. Gava, Thiago Melo C. Pereira, Elisardo C. Vasquez, Bianca P. Campagnaro and Silvana S. Meyrelles
    Citation: Journal of Biomedical Science 2015 22:97
    Content type: Research Published on:

  25. Serum sialic acid levels are positively correlated with coronary artery disease and inflammation. Although sialic acid is a non-specific marker, it is considered sensitive likely due to its influence in sialyl...

    Authors: Zhang Yida, Mustapha Umar Imam, Maznah Ismail, Norsharina Ismail, Aini Ideris and Maizaton Atmadini Abdullah
    Citation: Journal of Biomedical Science 2015 22:96
    Content type: Research article Published on:

  26. The HCMV UL76 gene is a member of UL24 family in herpes virus and encodes a highly conserved herpes virus protein. Inherited from common ancestor, members of Herpes_UL24 family encode proteins with a conserved N ...

    Authors: Wenchang Zhang, Yao Yao, Jingxian Chen and Mingli Wang
    Citation: Journal of Biomedical Science 2015 22:95
    Content type: Research Published on:

  27. The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids (EETs). sEH inhibition (sEHI) has proven to be p...

    Authors: Han-Fang Wu, Hsin-Ju Yen, Chi-Chen Huang, Yi-Chao Lee, Su-Zhen Wu, Tzong-Shyuan Lee and Hui-Ching Lin
    Citation: Journal of Biomedical Science 2015 22:94
    Content type: Research Published on:

  29. Chronic hepatitis B virus (HBV) infection in endemic areas usually starts since infancy and early childhood and persists lifelong. The clinical course varies among different chronic infected subjects. Majority...

    Authors: Jia-Feng Wu and Mei-Hwei Chang
    Citation: Journal of Biomedical Science 2015 22:92
    Content type: Review Published on:

  30. NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8+ T cells. The existence of an atypical cytotoxic CD4+NKG2D+ T cell population has also been found in patients with autoimmune dysfu...

    Authors: Mariel Garcia-Chagollan, Luis Felipe Jave-Suarez, Jesse Haramati, Miriam Ruth Bueno-Topete, Adriana Aguilar-Lemarroy, Ciro Estrada-Chavez, Blanca Estela Bastidas-Ramirez, Ana Laura Pereira-Suarez and Susana del Toro-Arreola
    Citation: Journal of Biomedical Science 2015 22:91
    Content type: Research Published on:

  31. Increasing evidence suggests that transforming growth factor-beta 1 (TGF-β1) triggers epithelial to mesenchymal transition (EMT) and facilitates breast cancer stem cell differentiation. Gelsolin (GSN) is a ubi...

    Authors: Zhi-Yuan Chen, Pei-Wen Wang, Dar-Bin Shieh, Kuan-Ying Chiu and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2015 22:90
    Content type: Research Published on:

  32. Canine parvovirus 2 (CPV-2) remains a significant worldwide canine pathogen and the most common cause of viral enteritis in dogs. The 1 L15 and 7 L15 peptides overlap each other with QPDGGQPAV residues (7-15 o...

    Authors: Serap Derman, Zeynep Akdeste Mustafaeva, Emrah Sefik Abamor, Melahat Bagirova and Adil Allahverdiyev
    Citation: Journal of Biomedical Science 2015 22:89
    Content type: Research Published on:

  33. It is well known that epigenetic modifications play an important role in controlling the regulation of gene expression during the development. Our previous studies have demonstrated that the expression of feta...

    Authors: Yang Xu, Lingjuan Liu, Bo Pan, Jing Zhu, Changlong Nan, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2015 22:88
    Content type: Research Published on:

  35. We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, the in vivo effect of miR-130b on fat de...

    Authors: Shifeng Pan, Xiaojing Yang, Yimin Jia, Yue Li, Rirong Chen, Min Wang, Demin Cai and Ruqian Zhao
    Citation: Journal of Biomedical Science 2015 22:86
    Content type: Research Published on:

  36. Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a wea...

    Authors: Aleksey V. Belikov, Burkhart Schraven and Luca Simeoni
    Citation: Journal of Biomedical Science 2015 22:85
    Content type: Review Published on:

  37. We have previously demonstrated that cigarette smoke is associated with a significant reduction of retinoic acid in rat lungs and the formation of tracheal precancerous lesions. However, the underlying mechani...

    Authors: Yuan Xue, Ethan Harris, Weiqun Wang and Richard C. Baybutt
    Citation: Journal of Biomedical Science 2015 22:84
    Content type: Research Published on:

  38. Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in...

    Authors: Daisy Vanitha John, Yee-Shin Lin and Guey Chuen Perng
    Citation: Journal of Biomedical Science 2015 22:83
    Content type: Review Published on:

  39. Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated re...

    Authors: Mohammad Charkhpour, Hamed Ghavimi, Saeed Ghanbarzadeh, Bahman Yousefi, Arash Khorrami, Mehran Mesgari and Kambiz Hassanzadeh
    Citation: Journal of Biomedical Science 2015 22:82
    Content type: Research Published on:

  40. Neuropathic pain is a very troublesome and difficult pain to treat. Although opioids are the best analgesics for cancer and surgical pain in clinic, only oxycodone among opioids shows better efficacy to allevi...

    Authors: Pao-Pao Yang, Geng-Chang Yeh, Eagle Yi-Kung Huang, Ping-Yee Law, Horace H. Loh and Pao-Luh Tao
    Citation: Journal of Biomedical Science 2015 22:81
    Content type: Research Published on:

  41. Cardiac oxidative stress, bioenergetics and catecholamine play major roles in heart failure progression. However, the relationships between these three dominant heart failure factors are not fully elucidated. ...

    Authors: Shih-Yi Lee, Hui-Chun Ku, Yueh-Hsiung Kuo, Kai-Chien Yang, Ping-Chen Tu, His-Lin Chiu and Ming-Jai Su
    Citation: Journal of Biomedical Science 2015 22:80
    Content type: Research Published on:

  42. The descending noradrenergic (NAergic) system is one of the important endogenous analgesia systems. It has been suggested that noxious stimuli could activate descending NAergic system; nevertheless, the underl...

    Authors: Chia-Yi Liu, Meng-Lam Lee, Chi-Sheng Yang, Chuan-Mu Chen, Ming-Yuan Min and Hsiu-Wen Yang
    Citation: Journal of Biomedical Science 2015 22:79
    Content type: Research Published on:

  43. In 2011, there was an outbreak of Shiga toxin-producing Escherichia coli (STEC) infections in Japan. Approximately 62 % of patients with hemolytic-uremic syndrome also showed symptoms of encephalopathy. To determ...

    Authors: Naotoshi Sugimoto, Hue Leu, Natsumi Inoue, Masaki Shimizu, Tomoko Toma, Mondo Kuroda, Takekatsu Saito, Taizo Wada and Akihiro Yachie
    Citation: Journal of Biomedical Science 2015 22:78
    Content type: Research Published on:

  44. Cisplatin is one of the most commonly used chemotherapy agent for lung cancer. The therapeutic efficacy of cisplatin is limited by the development of resistance.

    Authors: Chun-Hua Dai, Jian Li, Ping Chen, He-Guo Jiang, Ming Wu and Yong-Chang Chen
    Citation: Journal of Biomedical Science 2015 22:77
    Content type: Research Published on:

  45. Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a key regulator of signal cascades of TNF-α receptor and TLR4, and can induce NF-κB activation for preventing cell apoptosis and eliciting infl...

    Authors: Jang-Shiun Wang, Dean Wu, Duen-Yi Huang and Wan-Wan Lin
    Citation: Journal of Biomedical Science 2015 22:76
    Content type: Research Published on:

  46. Studies in recent years have shown that undercarboxylated osteocalcin (uOC) not only maintains bone mineralization, but is also involved in the regulation of atherosclerosis. However, a correlation between uOC...

    Authors: Minfang Zhang, Zhaohui Ni, Wenyan Zhou and Jiaqi Qian
    Citation: Journal of Biomedical Science 2015 22:75
    Content type: Research Published on:

  47. To construct safer recombinant flavivirus vaccine, we exploited Japanese encephalitis virus (JEV) replicon-based platform to generate single-round infectious particles (SRIPs) that expressed heterologous neutr...

    Authors: Yi-Ting Huang, Jia-Teh Liao, Li-Chen Yen, Yung-Kun Chang, Yi-Ling Lin and Ching-Len Liao
    Citation: Journal of Biomedical Science 2015 22:74
    Content type: Research Published on:

  48. Adiponectin levels have been shown to be associated with colorectal cancer (CRC). Furthermore, a newly identified adiponectin receptor, T-cadherin, has been associated with plasma adiponectin levels. Therefore...

    Authors: Jongkeun Park, Injung Kim, Keum Ji Jung, Soriul Kim, Sun Ha Jee and Sungjoo Kim Yoon
    Citation: Journal of Biomedical Science 2015 22:73
    Content type: Research Published on:

  49. Gene mutations that produce misprocessed proteins are linked to many human disorders. Interestingly, some misprocessed proteins retained their biological function when stabilized by low temperature treatment o...

    Authors: Yueqiang Zhang, William G. O’Brien III, Zhaoyang Zhao and Cheng Chi Lee
    Citation: Journal of Biomedical Science 2015 22:72
    Content type: Research Published on:

  50. Many patients with nasopharyngeal carcinoma (NPC) face poor prognosis. Due to its hidden anatomical location, the tumor is usually diagnosed quite late, and despite initially successful treatment with radiatio...

    Authors: Thomas C. Chen, Hee-Yeon Cho, Weijun Wang, Stephanie J. Wetzel, Anupam Singh, Jenny Nguyen, Florence M. Hofman and Axel H. Schönthal
    Citation: Journal of Biomedical Science 2015 22:71
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127