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  1. Colorectal cancer (CRC) is a major health concern worldwide, and recently becomes the most common cancer in Asia. The case collection of this study is one of the largest sets of CRC in Asia, and serves as repr...

    Authors: Chien-Hsing Lin, Jen-Kou Lin, Shih-Ching Chang, Ya-Hui Chang, Hwey-May Chang, Jin-Hwang Liu, Ling-Hui Li, Yuan-Tsong Chen, Shih-Feng Tsai and Wei-Shone Chen

    Citation: Journal of Biomedical Science 2011 18:36

    Content type: Research

    Published on:

  2. Autophagy plays a significant role in myocardial ischemia-reperfusion (IR) injury. So it is important to inhibit autophagy to protect cardiomyocytes besides anti-apoptosis. MiRNA has been demonstrated to prote...

    Authors: Jian Xiao, Xiaoyan Zhu, Bin He, Yufeng Zhang, Bo Kang, Zhinong Wang and Xin Ni

    Citation: Journal of Biomedical Science 2011 18:35

    Content type: Research

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  3. Mu opioid receptor (MOR), which plays key roles in analgesia and also has effects on learning and memory, was reported to distribute abundantly in the patches of the neostriatum. The marginal division (MrD) of...

    Authors: Chuanxing Wang, Si Yun Shu, Zhouyi Guo, Ye Feng Cai, Xinmin Bao, Changchun Zeng, Bingyi Wu, Ziyou Hu and Xuemei Liu

    Citation: Journal of Biomedical Science 2011 18:34

    Content type: Research

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  4. Adrenomedullin (ADM) exerts its biological functions through the receptor-mediated enzymatic mechanisms that involve protein kinase A (PKA), or neuronal nitric oxide synthase (nNOS). We previously demonstrated...

    Authors: David HT Yen, Lih-Chi Chen, Yuh-Chiang Shen, Ying-Chen Chiu, I-Chun Ho, Ya-Jou Lou, I-Chin Chen and Jiin-Cherng Yen

    Citation: Journal of Biomedical Science 2011 18:32

    Content type: Research

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  5. Hypoxia during the first week of life can induce neuronal death in vulnerable brain regions usually associated with an impairment of cognitive function that can be detected later in life. The neurobiological c...

    Authors: Thoppil R Anju, Sadanandan Jayanarayanan and Cheramadatikudiyil S Paulose

    Citation: Journal of Biomedical Science 2011 18:31

    Content type: Research

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  6. NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2), containing one iron sulfur cluster ([2Fe-2S] binuclear cluster N1a), is one of the core nuclear-encoded subunits existing in human mitochondrial complex...

    Authors: Hsin-Yu Liu, Pin-Chao Liao, Kai-Tun Chuang and Mou-Chieh Kao

    Citation: Journal of Biomedical Science 2011 18:29

    Content type: Research

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  7. Natural products have played a significant role in drug discovery and development. Inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) have been suggested to conn...

    Authors: I-Ni Hsieh, Anita Shin-Yuan Chang, Che-Ming Teng, Chien-Chih Chen and Chia-Ron Yang

    Citation: Journal of Biomedical Science 2011 18:28

    Content type: Research

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  8. Visfatin, a adipocytokine with insulin-mimetic effect, plays a role in endothelial angiogenesis. Hyperbaric oxygen (HBO) has been used in medical practice. However, the molecular mechanism of beneficial effect...

    Authors: Bao-Wei Wang, Chiu-Mei Lin, Gong-Jhe Wu and Kou-Gi Shyu

    Citation: Journal of Biomedical Science 2011 18:27

    Content type: Research

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  9. Granulocyte colony-stimulating factor (G-CSF), a hematopoietic cytokine, was recently used to treat patients of acute myocardial infarction with beneficial effect. However, controversy exists as some patients ...

    Authors: Wei S Lian, Heng Lin, Winston TK Cheng, Tateki Kikuchi and Ching F Cheng

    Citation: Journal of Biomedical Science 2011 18:26

    Content type: Research

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  10. Sensitivity of cancer cells to recombinant arginine deiminase (rADI) depends on expression of argininosuccinate synthetase (AS), a rate-limiting enzyme in synthesis of arginine from citrulline. To understand t...

    Authors: Fe-Lin Lin Wu, Yu-Fen Liang, Yuan-Chen Chang, Hao-Hsin Yo, Ming-Feng Wei and Li-Jiuan Shen

    Citation: Journal of Biomedical Science 2011 18:25

    Content type: Research

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  11. Artemin (ARTN) is a neurotrophic factor belonging to the glial cell-derived neurotrophic factor family of ligands. To develop potential therapy targeting ARTN, we studied the roles of miR-223 in the migration ...

    Authors: Shujun Li, Zhigang Li, Fengjie Guo, Xuebo Qin, Bin Liu, Zhe Lei, Zuoqing Song, Liya Sun, Hong-Tao Zhang, Jiacong You and Qinghua Zhou

    Citation: Journal of Biomedical Science 2011 18:24

    Content type: Research

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  12. Ischemic postconditioning (IPost) has aroused much attention since 2003 when it was firstly reported. The role of microRNAs (miRNAs or miRs) in IPost has rarely been reported. The present study was undertaken ...

    Authors: Bin He, Jian Xiao, An-Jing Ren, Yu-Feng Zhang, Hao Zhang, Min Chen, Bing Xie, Xiao-Gang Gao and Ying-Wei Wang

    Citation: Journal of Biomedical Science 2011 18:22

    Content type: Research

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  13. Antigen-specific immunotherapy using DNA vaccines has emerged as an attractive approach for the control of tumors. Another novel cancer therapy involves the employment of the vascular disrupting agent, 5,6-dim...

    Authors: Shiwen Peng, Archana Monie, Xiaowu Pang, Chien-Fu Hung and T-C Wu

    Citation: Journal of Biomedical Science 2011 18:21

    Content type: Research

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  14. Japanese encephalitis (JE) virus is the most common cause of epidemic viral encephalitis in the world. The virus mainly infects neuronal cells and causes an inflammatory response after invasion of the parenchy...

    Authors: Yu-Fen Tseng, Chien-Chih Wang, Shuen-Kuei Liao, Ching-Kai Chuang and Wei-June Chen

    Citation: Journal of Biomedical Science 2011 18:20

    Content type: Research

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  15. In order to understand the interaction between the metabotropic glutamate subtype 5 (mGluR5) and N-methyl-D-aspartate (NMDA) receptors, the influence of mGluR5 positive modulators in the inhibition of NMDA rec...

    Authors: Hwei-Hsien Chen, Pei-Fei Liao and Ming-Huan Chan

    Citation: Journal of Biomedical Science 2011 18:19

    Content type: Research

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  16. Myocardial ischemia/reperfusion injury is the major cause of morbidity and mortality for cardiovascular diseases. Dopamine D2 receptors are expressed in cardiac tissues. However, the roles of dopamine D2 receptor...

    Authors: Hong-zhu Li, Jin Guo, Jun Gao, Li-ping Han, Chun-ming Jiang, Hong-xia Li, Shu-zhi Bai, Wei-hua Zhang, Guang-wei Li, Li-na Wang, Hong Li, Ya-jun Zhao, Yan Lin, Ye Tian, Guang-dong Yang, Rui Wang…

    Citation: Journal of Biomedical Science 2011 18:18

    Content type: Research

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  17. Fragile X syndrome (FXS), the most commonly inherited mental retardation and single gene cause of autistic spectrum disorder, occurs when the Fmr1 gene is mutated. The product of Fmr1, fragile X linked mental ...

    Authors: Se Jin Jeon, Jung Eun Seo, Sung-Il Yang, Ji Woong Choi, David Wells, Chan Young Shin and Kwang Ho Ko

    Citation: Journal of Biomedical Science 2011 18:17

    Content type: Research

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  18. The extracellular calcium-sensing receptor (CaSR) belongs to family C of the G protein coupled receptors. Whether the CaSR is expressed in the pulmonary artery (PA) is unknown.

    Authors: Guang-wei Li, Qiu-shi Wang, Jing-hui Hao, Wen-jing Xing, Jin Guo, Hong-zhu Li, Shu-zhi Bai, Hong-xia Li, Wei-hua Zhang, Bao-feng Yang, Guang-dong Yang, Ling-yun Wu, Rui Wang and Chang-qing Xu

    Citation: Journal of Biomedical Science 2011 18:16

    Content type: Research

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  19. Serum response factor (SRF) regulates certain microRNAs that play a role in cardiac and skeletal muscle development. However, the role of SRF in the regulation of microRNA expression and microRNA biogenesis in...

    Authors: Xiaomin Zhang, Gohar Azhar, Scott A Helms and Jeanne Y Wei

    Citation: Journal of Biomedical Science 2011 18:15

    Content type: Research

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  20. Aging is a progressive process related to the accumulation of oxidative damage and neuroinflammation. We tried to find the anti-amnesic effect of the Scutellaria baicalens Georgia (SBG) ethanol extract and its ma...

    Authors: Kukhuon Jeong, Yong-Cheol Shin, Sunju Park, Jeong-Su Park, Namil Kim, Jae-Young Um, Hoyeon Go, Seungho Sun, Sundong Lee, Wansu Park, Youkyung Choi, Yunkyung Song, Gyungjun Kim, Chanyong Jeon, Jonghyeong Park, Keysang Lee…

    Citation: Journal of Biomedical Science 2011 18:14

    Content type: Research

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  21. Traumatic spinal cord injury (SCI) forms a disadvantageous microenvironment for tissue repair at the lesion site. To consider an appropriate time window for giving a promising therapeutic treatment for subacut...

    Authors: Chih-Yen Wang, Jen-Kun Chen, Yi-Ting Wu, May-Jywan Tsai, Song-Kun Shyue, Chung-Shi Yang and Shun-Fen Tzeng

    Citation: Journal of Biomedical Science 2011 18:13

    Content type: Research

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  22. The Cdc42-interacting protein-4, Trip10 (also known as CIP4), is a multi-domain adaptor protein involved in diverse cellular processes, which functions in a tissue-specific and cell lineage-specific manner. We...

    Authors: Chia-Chen Hsu, Yu-Wei Leu, Min-Jen Tseng, Kuan-Der Lee, Tzen-Yu Kuo, Jia-Yi Yen, Yen-Ling Lai, Yi-Chen Hung, Wei-Sheng Sun, Chien-Min Chen, Pei-Yi Chu, Kun-Tu Yeh, Pearlly S Yan, Yu-Sun Chang, Tim H-M Huang and Shu-Huei Hsiao

    Citation: Journal of Biomedical Science 2011 18:12

    Content type: Research

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  23. Taurine has chemical structure similar to an inhibitory neurotransmitter, γ-aminobutyric acid (GABA). Previous studies on GABA in the stomach suggest GABAergic neuron is involved in acid secretion, but the eff...

    Authors: Kai-Han Huang, Chia-Chieh Chang, Jau-Der Ho, Ruey-Hwa Lu and Li Hsueh Tsai

    Citation: Journal of Biomedical Science 2011 18:11

    Content type: Research

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  24. Transfer of full-length genes including regulatory elements has been the preferred gene therapy strategy for clinical applications. However, with significant drawbacks emerging, targeted gene alteration (TGA) ...

    Authors: Nanna M Jensen, Trine Dalsgaard, Maria Jakobsen, Roni R Nielsen, Charlotte B Sørensen, Lars Bolund and Thomas G Jensen

    Citation: Journal of Biomedical Science 2011 18:10

    Content type: Review

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  25. Dystonia musculorum (dt) is an autosomal recessive hereditary neuropathy with a characteristic uncoordinated movement and is caused by a defect in the bullous pemphigoid antigen 1 (BPAG1) gene. The neural isoform...

    Authors: Kuang-Wen Tseng, Mei-Lin Peng, Yang-Cheng Wen, Kang-Jen Liu and Chung-Liang Chien

    Citation: Journal of Biomedical Science 2011 18:9

    Content type: Research

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  26. Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acety...

    Authors: Shin-Hua Lu, Josephine W Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai and Yih Ho

    Citation: Journal of Biomedical Science 2011 18:8

    Content type: Research

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  27. The physiological processes in the cell are regulated by reversible, electrostatic protein-protein interactions. Apoptosis is such a regulated process, which is critically important in tissue homeostasis and d...

    Authors: Halina Z Malina

    Citation: Journal of Biomedical Science 2011 18:7

    Content type: Research

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  28. Hedgehog signalling has been implicated in prostate tumorigenesis in human subjects and mouse models, but its effects on transforming normal basal/stem cells toward malignant cancer stem cells remain poorly un...

    Authors: Han-Hsin Chang, Bo-Yie Chen, Chia-Yung Wu, Zih-Jay Tsao, Ying-Yu Chen, Chin-Pao Chang, Chi-Rei Yang and David Pei-Cheng Lin

    Citation: Journal of Biomedical Science 2011 18:6

    Content type: Research

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  29. Parkinson's disease is characterized by progressive cell death in the substantia nigra pars compacta, which leads to dopamine depletion in the striatum and indirectly to cortical dysfunction. Increased glutama...

    Authors: MS Nandhu, Jes Paul, Korah P Kuruvilla, Anitha Malat, Chinthu Romeo and CS Paulose

    Citation: Journal of Biomedical Science 2011 18:5

    Content type: Research

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  30. There are three apolipoprotein E (apoE) isoforms involved in human lipid homeostasis. In the present study, truncated apoE2-, apoE3- and apoE4-(72-166) peptides that are tailored to lack domain interactions ar...

    Authors: Yi-Hui Hsieh and Chi-Yuan Chou

    Citation: Journal of Biomedical Science 2011 18:4

    Content type: Research

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  31. Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors az...

    Authors: Yi-Shiuan Lin, Arthur Y Shaw, Shi-Gang Wang, Chia-Chen Hsu, I-Wen Teng, Min-Jen Tseng, Tim HM Huang, Ching-Shih Chen, Yu-Wei Leu and Shu-Huei Hsiao

    Citation: Journal of Biomedical Science 2011 18:3

    Content type: Research

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  32. Nijmegen breakage syndrome (NBS) is a chromosomal-instability syndrome associated with cancer predisposition, radiosensitivity, microcephaly, and growth retardation. The NBS gene product, NBS1 (p95) or nibrin,...

    Authors: Chung-Yin Wu, Chih-Ta Lin, Min-Zu Wu and Kou-Juey Wu

    Citation: Journal of Biomedical Science 2011 18:1

    Content type: Research

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  33. The gibbon ape leukemia virus (GALV), the amphotropic murine leukemia virus (AMLV) and the human T-cell leukemia virus (HTLV) are retroviruses that specifically bind nutrient transporters with their envelope g...

    Authors: Emmanuelle Lagrue, Hiroyuki Abe, Madakasira Lavanya, Jawida Touhami, Sylvie Bodard, Sylvie Chalon, Jean-Luc Battini, Marc Sitbon and Pierre Castelnau

    Citation: Journal of Biomedical Science 2010 17:91

    Content type: Research

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  34. Cytochrome b5 performs central roles in various biological electron transfer reactions, where difference in the redox potential of two reactant proteins provides the driving force. Redox potentials of cytochromes...

    Authors: Tomomi Aono, Yoichi Sakamoto, Masahiro Miura, Fusako Takeuchi, Hiroshi Hori and Motonari Tsubaki

    Citation: Journal of Biomedical Science 2010 17:90

    Content type: Research

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  35. Sodium/iodide symporter (NIS) mediates the active transport and accumulation of iodide from the blood into the thyroid gland. His-226 located in the extracellular region of NIS has been demonstrated to be crit...

    Authors: Chia-Cheng Li, Tin-Yun Ho, Chia-Hung Kao, Shih-Lu Wu, Ji-An Liang and Chien-Yun Hsiang

    Citation: Journal of Biomedical Science 2010 17:89

    Content type: Research

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  36. Effective vaccination against human papillomavirus (HPV) represents an opportunity to control cervical cancer. Peptide-based vaccines targeting HPV E6 and/or E7 antigens while safe, will most likely require ad...

    Authors: Chao-Yi Wu, Archana Monie, Xiaowu Pang, Chien-Fu Hung and T-C Wu

    Citation: Journal of Biomedical Science 2010 17:88

    Content type: Research

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  37. Melanomas, highly malignant tumors arise from the melanocytes which originate as multipotent neural crest cells during neural tube genesis. The purpose of this study is to assess the pattern of neural differen...

    Authors: Bhanu Iyengar and Avantika V Singh

    Citation: Journal of Biomedical Science 2010 17:87

    Content type: Research

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  38. Bacillus thuringiensis (Bt), an ubiquitous gram-positive spore-forming bacterium forms parasporal proteins during the stationary phase of its growth. Recent findings of selective human cancer cell-killing activit...

    Authors: Kanakeswary Krishnan, Jeremy Er An Ker, Shar Mariam Mohammed and Vishna Devi Nadarajah

    Citation: Journal of Biomedical Science 2010 17:86

    Content type: Research

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  39. Prenatal ethanol exposure during pregnancy induces a spectrum of mental and physical disorders called fetal alcohol spectrum disorder (FASD). The central nervous system is the main organ influenced by FASD, an...

    Authors: Ki Chan Kim, Hyo Sang Go, Hae Rang Bak, Chang Soon Choi, Inha Choi, Pitna Kim, Seol-Heui Han, So Min Han, Chan Young Shin and Kwang Ho Ko

    Citation: Journal of Biomedical Science 2010 17:85

    Content type: Research

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  40. Plumbagin is found in many herbal plants and inhibits the growth of various bacteria. Escherichia coli strains are relatively resistant to this drug. The mechanism of resistance is not clear. Previous findings sh...

    Authors: Ching-Nan Lin, Wan-Jr Syu, Wei-Sheng W Sun, Jenn-Wei Chen, Tai-Hung Chen, Ming-Jaw Don and Shao-Hung Wang

    Citation: Journal of Biomedical Science 2010 17:84

    Content type: Research

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  41. To assess the effects of Glycine tomentella Hayata (GTH), a traditional herbal medicine for treatment of rheumatic diseases on the expression of the proinflammatory cytokines and on the clearance of apoptotic cel...

    Authors: Jia-Hau Yen, Deng-Jye Yang, Meng-Chi Chen, Yu-Fan Hsieh, Yu-Shu Sun and Gregory J Tsay

    Citation: Journal of Biomedical Science 2010 17:83

    Content type: Research

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  42. Multicellular organisms are characterized by a remarkable diversity of morphologically distinct and functionally specialized cell types. Transgenic techniques for the manipulation of gene expression in specifi...

    Authors: Gerard Honig, Angela Liou, Miles Berger, Michael S German and Laurence H Tecott

    Citation: Journal of Biomedical Science 2010 17:82

    Content type: Research

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  43. Idiopathic membranous nephropathy (IMN) is one of the most common forms of autoimmune nephritic syndrome in adults. The purpose of this study is to evaluate whether polymorphisms of PLA2R1 affect the development ...

    Authors: Yu-Huei Liu, Cheng-Hsu Chen, Shih-Yin Chen, Ying-Ju Lin, Wen-Ling Liao, Chang-Hai Tsai, Lei Wan and Fuu-Jen Tsai

    Citation: Journal of Biomedical Science 2010 17:81

    Content type: Research

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  44. Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with diverse cytoprotective effects, and reported to have an important role in angiogenesis recently. Here we investigated whether HO-1 transduced by mesenc...

    Authors: Bin Zeng, Guosheng Lin, Xiaofeng Ren, Yan Zhang and Honglei Chen

    Citation: Journal of Biomedical Science 2010 17:80

    Content type: Research

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  45. GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease caused by deficiency of acid beta-galactosidase (GLB1; EC3.2.1.23). Here, we identify three novel mutations in the GLB1 gene from tw...

    Authors: Chi-Fan Yang, Jer-Yuarn Wu and Fuu-Jen Tsai

    Citation: Journal of Biomedical Science 2010 17:79

    Content type: Research

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