Peralta-Leal A, Rodríguez-Vargas JM, Aguilar-Quesada R, Rodríguez MI, Linares JL, de Almodóvar MR, Oliver FJ: PARP inhibitors: new partners in the therapy of cancer and inflammatory diseases. Free Radic Biol Med. 2009, 47: 13-26. 10.1016/j.freeradbiomed.2009.04.008.
Article
CAS
PubMed
Google Scholar
Ahmed EA, de Boer P, Philippens MEP, Kal HB, de Rooij DG: Parp1-XRCC1 and the repair of DNA double strand breaks in mouse round spermatids. Mutat Res. 2010, 683: 84-90.
Article
CAS
PubMed
Google Scholar
García-Soriano F, Virág L, Jagtap P, Szabó E, Mabley JG, Liaudeti L, Marton A, Hoyt DG, Murthy KGK, Salzman AL, Southan GJ, Szabó C: Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nature Med. 2001, 7: 108-113. 10.1038/83241.
Article
PubMed
Google Scholar
Minchenko AG, Stevens MJ, White L, Abatan OI, Komjáti K, Pacher P, Szabó C, Obrosova IG: Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. FASEB J. 2003, 17: 1514-1516.
CAS
PubMed
Google Scholar
Stevens MJ, Li F, Drel R, Abatan OI, Kim H, Burnett D, Larkin D, Obrosova IG: Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats. J Pharmacol Exp Ther. 2007, 320: 458-464. 10.1124/jpet.106.109702.
Article
CAS
PubMed
Google Scholar
Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, Wagner EF, Kolb H: Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin. Nature Med. 1999, 5: 314-319. 10.1038/6535.
Article
CAS
PubMed
Google Scholar
Cardinal JW, Allan DJ, Cameron DP: Poly(ADP-ribose)polymerase activation determines strain sensitivity to streptozotocin-induced β cell death in inbred mice. J Mol Endocrinol. 1999, 22: 65-70. 10.1677/jme.0.0220065.
Article
CAS
PubMed
Google Scholar
Pacher P, Szabó C: Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. Cardiovasc Drug Rev. 2007, 25: 235-260. 10.1111/j.1527-3466.2007.00018.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Charron MJ, Bonner-Weir S: Implicating PARP and NAD+ depletion in type I diabetes. Nature Med. 1999, 5: 269-270. 10.1038/6479.
Article
CAS
PubMed
Google Scholar
Suarez-Pinzón WL, Mabley JG, Power R, Szabó C, Rabinovitch A: Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes. Diabetes. 2003, 52: 1683-1688. 10.2337/diabetes.52.7.1683.
Article
PubMed
Google Scholar
Garcia Soriano F, Pacher P, Mabley J, Liaudet L, Szabó C: Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res. 2001, 89: 684-691. 10.1161/hh2001.097797.
Article
Google Scholar
Elliott RB, Pilcher CC, Stewart A, Fergusson D, McGregor MA: The use of nicotinamide in the prevention of type 1 diabetes. Ann NY Acad Sci. 2006, 696: 333-341. 10.1111/j.1749-6632.1993.tb17169.x.
Article
Google Scholar
Obrosova IG, Xu W, Lyzogubov W, Ilnytska O, Mashtalir N, Vareniuk I, Pavlov I, Zhang J, Slusher B, Drel VR: PARP inhibition or gene deficiency counteract intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. Free Radic Biol Med. 2008, 44: 972-981. 10.1016/j.freeradbiomed.2007.09.013.
Article
PubMed Central
CAS
PubMed
Google Scholar
Virág L, Szabó C: The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev. 2002, 54: 375-429. 10.1124/pr.54.3.375.
Article
PubMed
Google Scholar
Masiello P, Novelli M, Fierabracci V, Bergamini E: Protection by 3-aminobenzamide and nicotinamide against streptozotocin-induced β-cell toxicity in vivo and in vitro. Res Commun Chem Pathol Pharmacol. 1990, 69 (z): 17-32.
CAS
PubMed
Google Scholar
Gale EA, Bingley PJ, Emmett CL, Collier T, European Diabetes Intervention Trial (ENDIT Group): European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomized controlled trial of intervention before the onset of type 1 diabetes. Lancet. 2004, 363: 925-931. 10.1016/S0140-6736(04)15786-3.
Article
CAS
PubMed
Google Scholar
Olmos PR, Hodgson MI, Maiz A, Manrique M, Díaz De Valdés M, Foncea R, Acosta AM, Emmerich MV, Velasco S, Muñiz OP, Oyarzún CA, Claro JC, Bastías MJ, Toro LA: Nicotinamide protected first-phase insulin response (FPIR) and prevented clinical disease in first-degree relatives of type-1 diabetics. Diabetes Res Clin Pract. 2006, 71: 320-333. 10.1016/j.diabres.2005.07.009.
Article
CAS
PubMed
Google Scholar
Pociot F, Reimers JI, Andersen HU: Nicotinamide – biological actions and therapeutic potential in diabetes prevention. Diabetologia. 1993, 36: 574-576. 10.1007/BF02743277.
Article
CAS
PubMed
Google Scholar
Kulakowski EC, Maturo J: Hypoglycemic properties of taurine: not mediated by enhanced insulin release. Biochem Pharmacol. 1984, 33: 2835-2838. 10.1016/0006-2952(84)90204-1.
Article
CAS
PubMed
Google Scholar
Tokunaga H, Yoneida Y, Kuriyama K: Protective actions of taurine against streptozotocin-induced hyperglycemia. Biochem Pharmacol. 1979, 15: 2807-2811.
Google Scholar
Tas S, Sarandol E, Ayvalik SZ, Serdar Z, Dirican M: Vanadyl sulfate, taurine, and combined vanadyl sulfate and taurine treatments in diabetic rats: effects on the oxidative and antioxidative systems. Arch Med Res. 2007, 38: 276-283. 10.1016/j.arcmed.2006.09.018.
Article
CAS
PubMed
Google Scholar
Goodman HO, Shihabi ZK: Supplemental taurine in diabetic rats: effects on plasma glucose and triglycerides. Biochem Med Metab Biol. 1990, 43: 1-9. 10.1016/0885-4505(90)90002-I.
Article
CAS
PubMed
Google Scholar
Trachtman H, Futterweit D, Maesaka J, Ma C, Valderrama E, Fuchs A, Tarectecan AA, Rao PS, Sturman JA, Boles TH: Taurine ameliorates chronic streptozocin-induced diabetic nephropathy in rats. Am J Physiol. 1995, 269: F429-F438.
CAS
PubMed
Google Scholar
Arany E, Strutt B, Romanus P, Remacle C, Reusens B, Hill DJ: Taurine supplements in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic rats. Diabetologia. 2004, 47: 1831-1837. 10.1007/s00125-004-1535-z.
Article
CAS
PubMed
Google Scholar
Jorgensen WL, Maxwell D, Tirado-Rives J: Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids. J Am Chem. Soc. 1996, 118: 11225-11236. 10.1021/ja9621760.
Article
CAS
Google Scholar
Hattori K, Kido Y, Yamamoto H, Ishida J, Kamijo K, Murano K, Ohkubo M, Kinoshita T, Iwashita A, Mihara K, Yamazaki S, Matsuoka N, Teramura Y, Miyake H: Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose) polymerase. J Med Chem. 2004, 47: 4151-4154. 10.1021/jm0499256.
Article
CAS
PubMed
Google Scholar
Rabbo E, Terkildsen TC: On the enzymatic determination of blood glucose. Scand J Lab Invest. 1960, 12: 402-407. 10.3109/00365516009065404.
Article
Google Scholar
Buege JA, Aust SD: Microsomal lipid peroxidation. Methods Enzymol. 1978, 52: 302-310. full_text.
Article
CAS
PubMed
Google Scholar
Ellman G: Tissue sulphydryl groups. Arch Biochem Biophys. 1959, 32: 70-77. 10.1016/0003-9861(59)90090-6.
Article
Google Scholar
Kauser K, Sonnenberg D, Diel P, Rubanyi GM: Effect of 17β-oestradiol on cytokine-induced nitric oxide production in rat isolated aorta. Br J Pharmacol. 1998, 123: 1089-1096. 10.1038/sj.bjp.0701715.
Article
PubMed Central
CAS
PubMed
Google Scholar
Cepeda V, Fuertes MA, Castilla J, Alonso C, Quevedo C, Soto M, Perez JM: Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors in cancer chemotherapy. Recent Pat Anticancer Drug Discov. 2006, 1: 39-53. 10.2174/157489206775246430.
Article
CAS
PubMed
Google Scholar
Szkudelski T: The mechanism of alloxan and streptozotocin in B cells of the rat pancreas. Physiol Res. 2001, 50: 537-546.
CAS
PubMed
Google Scholar
Kröger H, Dietrich A, Ohde M, Lange R, Ehrlich W, Kurpitsz M: Protection from acetaminophen-induced liver damage by the synergistic action of low doses of the poly(ADP-ribose) polymerase inhibitor nicotinamide and the antioxidant N-acetylcysteine or the amino acid L-methionine. Gen Pharmacol. 1997, 28: 257-263.
Article
PubMed
Google Scholar
Bolzán AD, Bianchi MS: Genotoxicity of streptozotocin. Mutat Res. 2002, 512: 121-134. 10.1016/S1383-5742(02)00044-3.
Article
PubMed
Google Scholar
Oberley LW: Free radicals and diabetes. Free Radic Biol Med. 1988, 5: 113-124. 10.1016/0891-5849(88)90036-6.
Article
CAS
PubMed
Google Scholar
Anwar MM, Meki AR: Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comp Biochem Physiol A Mol Integr Physiol. 2003, 135: 539-547. 10.1016/S1095-6433(03)00114-4.
Article
PubMed
Google Scholar
Mabley JG, Suarez-Pinzon WL, Haskó G, Salzman AL, Rabinovitch A, Kun E, Szabó C: Inhibition of poly(ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low dose streptozotocin-induced diabetes. Br J Pharmacol. 2001, 133: 909-919. 10.1038/sj.bjp.0704156.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nukatsuka M, Sakurai H, Yoshimura Y, Nishida M, Kawada J: Enhancement by streptozotocin of O2- radical generation by the xanthine oxidase system of pancreatic β-cells. FEBS Lett. 1988, 239: 295-298. 10.1016/0014-5793(88)80938-4.
Article
CAS
PubMed
Google Scholar
Abdel-Wahab MH, Abd-Allah ARA: Possible protective effect of melatonin and/or desferrioxamine against streptozotocin-induced hyperglycaemia in mice. Pharmacol Res. 2000, 41: 533-537. 10.1006/phrs.1999.0614.
Article
CAS
PubMed
Google Scholar
Akimoto Y, Hart HW, Hirano H, Kawakami H: O-GlcNAc modification of nucleocytoplasmic proteins and diabetes. Med Mol Morphol. 2005, 38: 84-91. 10.1007/s00795-004-0264-1.
Article
CAS
PubMed
Google Scholar
Macauley MS, Whitworth GE, Debowski AW, Chin D, Vocadlo DJ: O-GlcNAcase uses substrate-assisted catalysis. Kinetic analysis and development of highly selective mechanism-inspired inhibitors,. J Biol Chem. 2005, 280: 25313-25322. 10.1074/jbc.M413819200.
Article
CAS
PubMed
Google Scholar
Curtin NJ: PARP inhibitors for cancer therapy. Expert Rev Mol Med. 2005, 7: 1-20. 10.1017/S146239940500904X.
Article
PubMed
Google Scholar
Knip M, Douek IF, Moore WPT, Gillmor HA, McLean AEM, Bingley PJ, Gale EAM: Safety of high-dose nicotinamide: a review. Diabetologia. 2000, 43: 1337-1345. 10.1007/s001250051536.
Article
CAS
PubMed
Google Scholar
Zhang J, Li JH: Poly(ADP-ribose) polymerase inhibition by genetic and pharmacological means. Cell Death: the Role of PARP. Edited by: Szabó C. 2000, Boca Raton: CRC Press LLC, 279-304.
Chapter
Google Scholar
Uchigata Y, Yamamoto H, Kawamura A, Okamoto H: Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982, 257: 6084-6088.
CAS
PubMed
Google Scholar
Rodrigues B, Poucheret P, Battell ML, McNeill JH: Streptozotocin-induced diabetes. Induction, mechanism(s), and dose dependency. Experimental Methods of Diabetes. Edited by: McNeill JH. 1999, Boca Raton: CRC Press LLC, 3-18.
Google Scholar
Komolafe OA, Adeyemi DO, Adewole SO, Obuotor EM: Streptozotocin-induced diabetes alters the serum lipid profiles of adult Wistar rats. Internet J Cardiovasc Res. 2009, 7: 1-
Google Scholar
Tabatabaie T, Vasquez-Weldon A, Moore DR, Kotakae Y: Free Radicals and the pathogenesis of type 1 diabetes β-cell cytokine-mediated free radical generation via cyclooxygenase-2. Diabetes. 2003, 52: 1994-1999. 10.2337/diabetes.52.8.1994.
Article
CAS
PubMed
Google Scholar
Mano T, Shinohara R, Nagasaka A, Nakagawa H, Uchimura K, Hayashi R, Nakano I, Tsugawa T, Watanabe F, Kobayashi T, Fujiwara K, Nakai A, Itoh M: Scavenging effect of nicorandil on free radicals and lipid peroxide in streptozotocin-induced diabetic rat. Metabolism. 2000, 49: 427-431. 10.1016/S0026-0495(00)80003-7.
Article
CAS
PubMed
Google Scholar
Mullarkey CJ, Edelstein D, Brownlee M: Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochem Biophys Res Commun. 1990, 173: 932-939. 10.1016/S0006-291X(05)80875-7.
Article
CAS
PubMed
Google Scholar
Takasu N, Komiya I, Asawa T, Nagasawa Y, Yamada T: Streptozotocin- and alloxan-induced H2O2 generation and DNA fragmentation in pancreatic islets. H2O2 as mediator for DNA fragmentation. Diabetes. 1991, 40: 1141-1145. 10.2337/diabetes.40.9.1141.
Article
CAS
PubMed
Google Scholar
Coskun O, Kanter M, Korkmaz A, Oter S: Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol Res. 2005, 51: 117-123. 10.1016/j.phrs.2004.06.002.
Article
CAS
PubMed
Google Scholar
Kawada J: New hypothesis for the mechanism of streptozotocin and alloxan inducing diabetes mellitus. Yakugaku Zasshi. 1992, 112: 773-791.
CAS
PubMed
Google Scholar
Adams JD, Lauterburg BH, Mitchell JR: Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. J Pharmacol Exp Ther. 1983, 227: 749-754.
CAS
PubMed
Google Scholar
Zingarelli B, Cuzzocrea S, Zsengellér Z, Salzman AL, Szabó C: Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase. Cardiovasc Res. 1997, 36: 205-215. 10.1016/S0008-6363(97)00137-5.
Article
CAS
PubMed
Google Scholar
Czapski G, Cakala M, Kopczuk D, Strosznajder JB: Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex. Neurosci Lett. 2004, 356: 45-48. 10.1016/j.neulet.2003.11.022.
Article
CAS
PubMed
Google Scholar
Fiaschi AI, Cozzolino A, Ruggiero G, Giorgi G: Glutathione, ascorbic acid and antioxidant enzymes in the tumor tissue and blood of patients with oral squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 2005, 9: 361-367.
CAS
PubMed
Google Scholar
Melo SS, Arantes MR, Meirelles MS, Jordão AA, Vannucchi H: Lipid peroxidation in nicotinamide-deficient and nicotinamide-supplemented rats with streptozotocin-induced diabetes. Acta Diabetol. 2000, 37: 33-39. 10.1007/s005920070033.
Article
CAS
PubMed
Google Scholar
Shen CC, Huang HM, Ou HC, Chen HL, Chen WC, Jeng KC: Protective effect of nicotinamide in neuronal cells under oxygen and glucose deprivation and hypoxia/reoxygenation. J Biomed Sci. 2004, 11: 472-481. 10.1007/BF02256096.
Article
CAS
PubMed
Google Scholar
Trachtman H, Futterweit S, Bienkowski RS: Taurine prevents glucose-induced lipid peroxidation and increased collagen production in cultured rat mesangial cells. Biochem Biophys Res Commun. 1993, 191: 759-765. 10.1006/bbrc.1993.1282.
Article
CAS
PubMed
Google Scholar
Kumar JS, Menon VP: Peroxidative changes in experimental diabetes mellitus. Indian J Med Res. 1992, 96: 176-181.
CAS
PubMed
Google Scholar
Yamada T, Suzuki T, Takama K: Protective effect of sulfoquinovosyldiglyceride (SQDG) and taurine against lipid peroxidation. Trace Nutrients Res. 1996, 13: 43-50.
Google Scholar
Nakamura T, Ogasawara M, Koyama I, Nemoto M, Yoshida T: The protective effect of taurine on the biomembrane against damage produced by oxygen radicals. Biol Pharm Bull. 1993, 16: 970-972.
Article
CAS
PubMed
Google Scholar
Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, Liu P, Sole MJ, Backx PH: Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation. 2004, 109: 1877-1885. 10.1161/01.CIR.0000124229.40424.80.
Article
CAS
PubMed
Google Scholar
Hanna J, Chahine R, Aftimos G, Nader M, Mounayar A, Esseily F, Chamat S: Protective effect of taurine against free radicals damage in the rat myocardium. Exp Toxicol Pathol. 2004, 56: 189-194. 10.1016/j.etp.2004.08.004.
Article
CAS
PubMed
Google Scholar
Aruoma OI, Halliwell B, Hoey BM, Butler J: The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem J. 1988, 256: 251-255.
Article
PubMed Central
CAS
PubMed
Google Scholar
Schaffer SW, Azuma J, Nozaffari M: Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol. 2009, 87: 91-99. 10.1139/Y08-110.
Article
CAS
PubMed
Google Scholar